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Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-310 Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
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SYNONYMS AKβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-310-M005   5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C32H48O5
MW: 512.7
CAS NUMBER: 67416-61-9
SOURCE/HOST: Isolated from Boswellia serrata.
PURITY: ≥99% (HPLC, NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No. ALX-350-308). Exhibits in vivo efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I: R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther. 288, 613 (1999) Abstract; Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization: A. Altmann, et al.; BBRC 290, 185 (2002) Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes: A. Altmann, et al.; Br. J. Pharmacol. 141, 223 (2004) Abstract; Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis: C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid: M. Bishnoi, et al.; Indian J. Exp. Biol. 44, 128 (2006) Abstract
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Further Categories Containing This Product:
Natural Products - Protein Kinase Inhibitors • Lipoxygenases / Related Products • NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Apoptosis Inducers) • Natural Products - Topoisomerase Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-260-128 Revised 03-Apr-08
Actinonin
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SYNONYMS 3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-260-128-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C19H35N3O5
MW: 385.5
CAS NUMBER: 13434-13-4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of aminopeptidase M, leucine aminopeptidase and deformylase. Shows antitumor activity. Apoptosis inducer.
Product Specific Literature References
Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. (Tokyo) 38, 1629 (1985) Abstract
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987) Abstract
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin: K. Sayama, et al.; Cancer Lett 94, 171 (1995) Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299: U. Lendeckel, et al.; BBRC 252, 5 (1998) Abstract
Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998) Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000) Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004) Abstract
Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2005) Abstract
Further Categories Containing This Product:
Aminopeptidases / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-350-329 Revised 21-May-08
Allicin
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SYNONYMS 2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-329-M001   1 mg 200.00 USD Add To Cart
ALX-350-329-M005   5 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C6H10OS2
MW: 162.3
CAS NUMBER: 539-86-6
MERCK INDEX: 14: 261
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Clear to slightly yellow liquid.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • TRPV1 Agonists and Antagonists / Related Products
 
 
ALX-350-016 Revised 31-Jul-08
(+)-Aphidicolin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cell Cycle Research
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ALX-350-016-M001   1 mg 65.00 USD Add To Cart
ALX-350-016-M005   5 mg 260.00 USD Add To Cart
ALX-350-016-M025   25 mg 890.00 USD Add To Cart
Product Specification
FORMULA: C20H34O4
MW: 338.5
CAS NUMBER: 38966-21-1
MERCK INDEX: 14: 727
RTECS: PB9185000
SOURCE/HOST: Isolated from Nigrospora oryzae.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (50mg/ml), methanol (10mg/ml) or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
Product Specific Literature References
X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system: K.M. Brundret, et al.; J. C. S. Chem. Commun. 1027 (1972)
The production of aphidicolin by Nigrospora sphaerica: A.N. Starratt and S.R Loschiavo; Can. J. Microbiol. 20, 416 (1974)
Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha: S. Ikegami, et al.; Nature 275, 458 (1978) Abstract
Inhibition by aphidicolin of cell cycle progression and DNA replication in sea urchin embryos: S. Ikegami, et al.; J. Cell. Physiol. 100, 439 (1979) Abstract
New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha: J.A. Huberman; Cell 23, 647 (1981) Abstract
Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes: S. Spadari, et al.; TIBS 7, 29 (1982)
Aphidicolin potentiates apoptosis induced by arabinosyl nucleosides in human myeloid leukemia cell lines: K. Kuwakado, et al.; Biochem. Pharmacol. 46, 1909 (1993) Abstract
Life, death and genomic change in perturbed cell cycles: R.T. Schimke, et al.; Philos. Trans. R. Soc. London B Biol. Sci. 345, 311 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3: M.M. Borner, et al.; Cancer Res. 55, 2122 (1995) Abstract
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells: W. Poluha, et al.; Oncogene 10, 185 (1995) Abstract
Coordinate regulation of G- and C strand length during new telomere synthesis: X. Fan and C.M. Price; Mol. Biol. Cell 8, 2145 (1997) Abstract; Full Text
Effect of aphidicolin on DNA methyltransferase in the nucleus: I. Suetake, et al.; Cell Struct. Funct. 23, 137 (1998) Abstract
Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine: M. Michaelis, et al.; Anticancer Drugs 11, 479 (2000) Abstract
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study: B. Tedeschi, et al.; Mutat. Res. 546, 55 (2004) Abstract
Further Categories Containing This Product:
Natural Products - Other Tumor Promoters • Cell Cycle Blockers & Inhibitors / Related Products • Carcinogens & Tumor Promoters Other Products • Natural Products - DNA Replication Inhibitors • DNA Replication Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-095 Revised 03-Apr-08
Apicidin
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SYNONYMS cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-095-M001   1 mg 50.00 USD Add To Cart
ALX-350-095-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C34H49N5O6
MW: 623.8
CAS NUMBER: 183506-66-3
SOURCE/HOST: Isolated from Fusarium sp.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.

Product Description
Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest. Stimulates apoptosis of cancer cells. Antiprotozoal.
Product Specific Literature References
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase: S.J. Darkin-Rattray, et al.; PNAS 93, 13143 (1996) Abstract
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin: J.W. Han, et al.; Cancer Res. 60, 6068 (2000) Abstract
Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor: J.S. Kim, et al.; BBRC 281, 866 (2001) Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1: S.L. Colletti, et al.; Bioorg. Med. Chem. Lett. 11, 107 (2001) Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2: S.L. Colletti, et al.; Bioorg. Med. Chem. Lett. 11, 113 (2001) Abstract
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities: S.B. Singh, et al.; J. Org. Chem. 67, 815 (2002) Abstract
Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells: J. Hong, et al.; Cancer Lett. 189, 197 (2003) Abstract
Activation of NF-kappaB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis: Y.K. Kim, et al.; Cell Death Differ. 13, 2033 (2006) Abstract
Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells: T. Ueda, et al.; Int. J. Mol. Med. 19, 301 (2007) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • HDAC Inhibitors • Natural Products for Cell Cycle Research • Natural Products - Other Anti-infective Agents • Parasitic Diseases Other Products • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-385-008 Revised 13-Mar-08
Apigenin
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SYNONYMS 4',5,7-Trihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-008-M010   10 mg 35.00 USD Add To Cart
ALX-385-008-M050   50 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 520-36-5
MERCK INDEX: 14: 730
SOURCE/HOST: Synthetic.
PURITY: ≥90% (HPLC)
APPEARANCE: Light yellow to slightly brown powder.
SOLUBILITY: Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.
Product Specific Literature References
Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Hypoxia-inducible Factor [HIF] / Related Products • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Protein Kinase Inhibitors • VEGFs & VEGF-Rs Other Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Antitumor Agents (Anti-proliferative) • Natural Products - Antioxidants
 
 
ALX-350-129 Revised 04-Dec-07
Aristoforin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-129-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C37H54O6
MW: 594.8
CAS NUMBER: 849215-53-8
PURITY: ≥95%
APPEARANCE: White to yellow oil.
SOLUBILITY: Soluble in DMSO or 100mM sodium hydrogen carbonate/2% DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Stable and water-soluble derivative of hyperforin (Prod. No. ALX-350-097) inducing apoptosis. Antitumor agent. Inhibits sirtuins.
Product Specific Literature References
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem. 6, 171 (2005) Abstract
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2: C. Gey, et al.; Angew. Chem. Int. Ed. Engl. 46, 5219 (2007) Abstract
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Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Sirtuins / Related Products • Natural Products - Antitumor Reagents
 
 
ALX-460-001 Revised 13-Mar-06
L-(+)-Ascorbic acid
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SYNONYMS Vitamin C
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-001-G010   10 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H8O6
MW: 176.1
CAS NUMBER: 50-81-7
MERCK INDEX: 14: 830
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.

Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables
 
 
ALX-350-361 Revised 17-Mar-08
Auraptene
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SYNONYMS 7-Geranyloxycoumarin
7-[(2E)-3,7-Dimethylocta-2,6-dienoxy]chromen-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-361-M005   5 mg 25.00 USD Add To Cart
ALX-350-361-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C19H22O3
MW: 298.4
CAS NUMBER: 495-02-3
SOURCE/HOST: Isolated from citrus fruit.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by NMR.

Product Description
Anti-inflammatory and chemopreventive compound. Exerts tumor preventive effects through apoptosis. Suppresses cell proliferation and lipid peroxidation. Acts as an agonist of PPARs. Induces phase II drug-metabolizing enzymes.
Product Specific Literature References
Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes: T. Tanaka, et al.; Cancer Res. 58, 2550 (1998) Abstract; Full Text
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice: T. Tanaka, et al.; Carcinogenesis 20, 1471 (1999) Abstract; Full Text
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells: H. Mori, et al.; Mutat. Res. 480-481, 201 (2001) Abstract
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins: M. Curini, et al.; Bioorg. Med. Chem. Lett. 14, 2241 (2004) Abstract
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism: K. Kawabata, et al.; FEBS Lett. 580, 5288 (2006) Abstract
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes: K. Kuroyanagi, et al.; BBRC 366, 219 (2008) Abstract
Further Categories Containing This Product:
PPAR Agonists • Antitumor Agents (Apoptosis Inducers) • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-385-022 Revised 07-Oct-08
Baicalein
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SYNONYMS 5,6,7-Trihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-022-M005   5 mg 25.00 USD Add To Cart
ALX-385-022-M025   25 mg 100.00 USD Add To Cart
Product Specification