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DNA Regulation / Transcription
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ALX-270-418 Revised 16-Jun-08
Gallotannin
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SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • PARG / Related Products • DNA Repair Other Products • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids
 
 
ALX-480-094 Revised 07-Oct-08
ADP-HPD . ammonium salt . dihydrate
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SYNONYMS Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH4 . 2H2O
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-094-C060   60 µg 188.00 USD Add To Cart
Product Specification
FORMULA: C15H23N6O12P2 . NH4 . 2H2O
MW: 541.3 . 18.0 . 36.0
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.

Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995) Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995) Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage: S. Vispe, et al.; PNAS 97, 9886 (2000) Abstract; Full Text
Further Categories Containing This Product:
DNA Repair Other Products • PARG / Related Products
 
 
ALX-270-044 Revised 20-Oct-08
3-Aminobenzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-044-G001   1 g 50.00 USD Add To Cart
ALX-270-044-G005   5 g 190.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O
MW: 136.2
CAS NUMBER: 3544-24-9
RTECS: CU8992000
PURITY: ≥97%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. Apoptosis inhibitor.
Product Specific Literature References
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC 179, 1225 (1991) Abstract
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994) Abstract
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994) Abstract
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995) Abstract
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995) Abstract
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • DNA Repair Other Products
 
 
ALX-270-174 Revised 20-Oct-08
Benzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-174-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C7H7NO
MW: 121.1
CAS NUMBER: 55-21-0
MERCK INDEX: 14: 1060
RTECS: CU8700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Neuroprotectant.
Product Specific Literature References
Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells: H.N. Jayaram, et al.; BBRC 186, 1600 (1992) Abstract
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-221 Revised 23-Jul-07
DPQ
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SYNONYMS 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-221-M001   1 mg 52.00 USD Add To Cart
ALX-270-221-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C18H26N2O2
MW: 302.4
CAS NUMBER: 129075-73-6
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown solid.
SOLUBILITY: Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 1 month when stored at -20°C.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.
Product Specific Literature References
Dihydroisoquinolines: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase: M.J. Suto, et al.; Anticancer Drug Des. 6, 107 (1991) Abstract
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia: M.J.L. Eliasson, et al.; Nat. Med. 3, 1089 (1997) Abstract
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats: H. Takahashi, et al.; J. Cereb. Blood Flow Metab. 17, 1137 (1997) Abstract
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS 19, 287 (1998), (Review) Abstract
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res. 829, 46 (1999) Abstract; Full Text
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ. 8, 921 (2001) Abstract
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab. 22, 697 (2002) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-250 Revised 18-Jan-06
4-Amino-1,8-naphthalimide
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SYNONYMS 4-ANI
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-250-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C12H8N2O2
MW: 212.2
CAS NUMBER: 1742-95-6
RTECS: DE4081000
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for 3 months when stored at –20°C.
HAZARD: IRRITANT.

Product Description
Potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=0.18µM). About 1000-fold more potent than 3-aminobenzamide (Prod. No. ALX-270-044).
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion: J. Radons, et al.; BBRC 199, 1270 (1994) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle: C. Thiemermann, et al.; PNAS 94, 679 (1997) Abstract; Full Text
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers: J. Bowes & C. Thiemermann; Br. J. Pharmacol. 124, 1254 (1998) Abstract
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer: A. Schlicker, et al.; Int. J. Radiat. Biol. 75, 91 (1999) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-251 Revised 20-Oct-08
6(5H)-Phenanthridinone
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-251-M010   10 mg 15.00 USD Add To Cart
Product Specification
FORMULA: C13H9NO
MW: 195.2
CAS NUMBER: 1015-89-0
RTECS: SG0370000
PURITY: ≥95%
APPEARANCE: Light brown solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Poly(ADP-ribose)polymerase (PARP) inhibitor.
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor: D. Weltin, et al.; Int. J. Immunopharmacol. 17, 265 (1995) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis: D. Weltin, et al.; Biochem. Pharmacol. 51, 1123 (1996) Abstract
Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells: D. Weltin, et al.; Int. J. Radiat. Biol. 72, 685 (1997) Abstract
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase: M.R. Cookson, et al.; J. Neurochem. 70, 501 (1998) Abstract
Effects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells: D.S. Richardson, et al.; Adv. Exp. Med. Biol. 457, 267 (1999) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-278 Revised 01-Jul-08
5-Iodo-6-amino-1,2-benzopyrone
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SYNONYMS INH2BP
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-278-M001   1 mg 25.00 USD Add To Cart
ALX-270-278-M005   5 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C9H6INO2
MW: 287.1
CAS NUMBER: 137881-27-7
PURITY: ≥98%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase: P.I. Bauer, et al.; Biochimie 77, 374 (1995) Abstract
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development: M. Endres, et al.; Eur. J. Pharmacol. 351, 377 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells: M. Kennedy, et al.; Gastroenterology 114, 510 (1998) Abstract
Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock: C. Szabó, et al.; Shock 9, 341 (1998) Abstract
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase: C. Szabó, et al.; PNAS 95, 3867 (1998) Abstract; Full Text
Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation: L. Virág, et al.; Free Radic. Biol. Med. 25, 1075 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death: L. Virág, et al.; J. Immunol. 161, 3753 (1998) Abstract; Full Text
Novel roles of nitric oxide in hemorrhagic shock: C. Szabo & T.R. Billiar; Shock 12, 1 (1999) Abstract
Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME): E. Kirsten & E. Kun; Int. J. Mol. Med. 5, 279 (2000) Abstract
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis: G.S. Scott, et al.; J. Neuroimmunol. 117, 78 (2001) Abstract
Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes: J.G. Mabley, et al.; Br. J. Pharmacol. 133, 909 (2001) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-279 Revised 20-Oct-08
4-Hydroxyquinazoline
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SYNONYMS 4-Quinazolinol
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-279-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C8H6N2O
MW: 146.2
CAS NUMBER: 491-36-1
RTECS: VA2300000
PURITY: ≥98%
APPEARANCE: White to grey solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008)