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TRAIL & TRAIL Receptors / Related Products
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > TRAIL & TRAIL Receptors / Related Products
 
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ALX-201-123 Revised 06-Jun-08
KillerTRAIL™, Soluble (human) (recombinant) (BULK)
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SYNONYMS Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-123-C500   500 µg 1'400.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION: 0.5mg/ml.
PURITY: ≥99% (SDS-PAGE)
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 20mM HEPES, pH 7.9, containing 120mM sodium chloride, 0.01% Tween 20, 1% sucrose, 1mM DTT.
ENDOTOXIN CONTENT: <0.2EU/µg protein (LAL test; Bio Whittaker).
RECONSTITUTION: For a special storage and dilution buffer see KillerTRAIL™ Storage and Dilution Buffer (Prod. No. ALX-505-005).
SPECIFICITY: Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY: Induces apoptosis in a concentration range of 10-100ng/ml.
Note: This protein does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SuperKillerTRAIL™ (Prod. No. ALX-201-115).
SPECIFIC ACTIVITY: ED50: 20ng/ml (BJAB cells)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
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Product Specific Literature References
The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001) Abstract; Full Text
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001) Abstract; Full Text
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract
TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Sträter, et al.; Gastroenterology 122, 659 (2002) Abstract
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1: M. MacFarlane, et al.; Cell Death Differ. 12, 773 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-505-005 Revised 23-Jul-08
KillerTRAIL™ Storage and Dilution Buffer
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PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-505-005-R500   500 µl 60.00 USD Add To Cart
Product Specification
PURITY DETAIL: Sterile filtered.
FORMULATION: Liquid. 20mM HEPES, pH 7.4, containing 300mM NaCl, 0.01% Tween 20, 1% sucrose and 1mM DTT.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Storage and dilution buffer for use with the following products:
KillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-073)
SuperKillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-115)
SuperKillerTRAIL™, Soluble (mouse) (recombinant) (Prod. No. ALX-201-130)

Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with KillerTRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the KillerTRAIL™ or SuperKillerTRAIL™ stock solution is necessary because of their high activity). Predilution with KillerTRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.
General Information
BACKGROUND/TECHNICAL INFORMATION Prepare a 1:10 dilution of KillerTRAIL™ or SuperKillerTRAIL™ with KillerTRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted KillerTRAIL™ or SuperKillerTRAIL™ on ice until adding to cells. For storage, prepare aliquots and freeze at -80°C.
Related Products
Further Categories Containing This Product:
TRAIL [Apo-2L]
 
 
ALX-201-073 Revised 20-Nov-08
KillerTRAIL™, Soluble (human) (recombinant)
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SYNONYMS Apo-2L, Soluble (human) (recombinant)
TNFSF 10, Soluble (human) (recombinant)
CD253, Soluble (human) (recombinant)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-073-C020   20 µg 360.00 USD Add To Cart
ALX-201-073-3020 SuperPack 3x20 µg 720.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
CONCENTRATION: 0.5mg/ml   
PURITY: ≥99% (SDS-PAGE)
PURITY DETAIL: Affinity purified. Sterile filtered.
FORMULATION: Liquid. In 20mM HEPES, pH 7.9, 120mM sodium chloride, 0.01% Tween 20, 1% sucrose and 1mM DTT.
ENDOTOXIN CONTENT: ≤0.004EU/μg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: For a special storage and dilution buffer see KillerTRAIL™ Storage and Dilution Buffer (Prod. No. ALX-505-005).
SPECIFICITY: Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG).
BIOLOGICAL ACTIVITY: Induces apoptosis in a concentration range of 10-100ng/ml.
Note: Does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SuperKillerTRAIL™ (Prod. No. ALX-201-115).
SPECIFIC ACTIVITY: ED50: 20ng/ml (BJAB cells)
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The cytokines tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papilloma: J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001) Abstract; Full Text
The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001) Abstract
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract; Full Text
TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Sträter, et. al.; Gastroenterology 122, 659 (2002) Abstract
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1: M. MacFarlane, et al.; Cell Death Differ. 12, 773 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50591: TRAIL (human)
AfCS Signalling Gateway link A002862: TRAIL (mouse)
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-804-817 Revised 26-Feb-07
Monoclonal Antibody to DcTRAIL-R2 (mouse) (Lucy-1)
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SYNONYMS anti-TNFRH2 (mouse) MAb (Lucy-1)
anti-TNFRSF22 (mouse) MAb (Lucy-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY DcTRAIL-R2
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-817-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: Lucy-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse DcTRAIL-R2 extracelluar domain (aa 1-170) (Prod. No. ALX-522-068).
SPECIFICITY: Recognizes mouse DcTRAIL-R2. Does not cross-react with mouse DcTRAIL-R1.
APPLICATION: Flow Cytometry (1:1'000)
Note: Not suitable for immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt if stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-296 Revised 09-Apr-08
Monoclonal Antibody to TRAIL (human) (2E5)
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SYNONYMS anti-Apo-2L (human) MAb (2E5)
anti-TNFSF 10 (human) MAb (2E5)
anti-CD253 (human) MAb (2E5)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-296-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 2E5
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified. Sterile filtered.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human soluble TRAIL (aa 95-281).
SPECIFICITY: Recognizes human TRAIL. Does not cross-react with mouse TRAIL.
APPLICATION: Flow Cytometry
Functional Application (excellent): neutralizes human TRAIL mediated killing in a concentration range of 0.5-1.5µg/ml. 
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract
IFN{alpha}-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells: C. Tecchio, et al.; Blood 103, 3837 (2004) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-300 Revised 04-Mar-05
Monoclonal Antibody to TRAIL (human) (HS501)
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SYNONYMS anti-Apo-2L (human) MAb (HS501)
anti-TNFSF 10 (human) MAb (HS501)
anti-CD253 (human) MAb (HS501)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-300-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HS501
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrate hybridoma tissue culture supernatant.
CONCENTRATION: 0.25mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing PEG-sucrose and 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: Western Blot (excellent)
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. Thaw at +37°C.
Product Images
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Product Specific Literature References
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-326 Revised 03-Nov-08
Monoclonal Antibody to TRAIL (human) (III6F)
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SYNONYMS anti-APO-2L (human) MAb (III6F)
anti-TNFSF 10 (human) MAb (III6F)
anti-CD253 (human) MAb (III6F)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-326-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: III6F
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Method. 259, 119 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-325 Revised 03-Nov-08
Monoclonal Antibody to TRAIL (human) (VI10E)
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SYNONYMS anti-Apo-2L (human) MAb (VI10E)
anti-TNFSF 10 (human) MAb (VI10E)
anti-CD253 (human) MAb (VI10E)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-325-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: VI10E
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: ELISA
Flow Cytometry
Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Methods 259, 119 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-297 Revised 24-Jun-08
Monoclonal Antibody to TRAIL-R1 (human) (HS101)
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SYNONYMS anti-DR4 (human) MAb (HS101)
anti-TNFRSF 10A (human) MAb (HS101)
anti-CD261 (human) MAb (HS101)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL-R1
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-297-C100 Preservative Free 100 µg 330.00 USD Add To Cart
ALX-804-297A-C100 Purified 100 µg 330.00 USD Add To Cart
ALX-804-297F-T100 FITC 100 tests 380.00 USD Add To Cart