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ALX-270-095
Revised 07-May-08
5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole
SYNONYMS
DRB
5,6-Dichlorobenzimidazole riboside
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-095-M005
5 mg
20.00 USD
ALX-270-095-M025
25 mg
70.00 USD
Product Specification
FORMULA:
C
12
H
12
Cl
2
N
2
O
4
MW:
319.1
CAS NUMBER:
53-85-0
RTECS:
DD7310000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO (100mM) or dimethyl formamide (100mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Selective casein kinase II inhibitor. Inhibitor of RNA synthesis in eukaryotic cells.
Product Specific Literature References
Halobenzimidazole ribosides and RNA synthesis of cells and viruses:
I. Tamm & P. Sehgal; Adv. Virus Res.
22
, 187 (1978)
Abstract
Mechanism of action of 5,6-dichloro-1-beta-D- ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery:
B. Mittleman, et al.; J. Mol. Biol.
165
, 461 (1983)
Abstract
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription:
R. Zandomeni, et al.; J. Mol. Biol.
167
, 561 (1983)
Abstract
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1- beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription:
R. Zandomeni, et al.; J. Biol. Chem.
261
, 3414 (1986)
Abstract
;
Full Text
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6- dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB):
C.E. Farin & L. Yang; Mol. Reprod. Dev.
37
, 284 (1994)
Abstract
Further Categories Containing This Product:
Casein Kinase Inhibitors
ALX-350-149
Revised 23-Oct-07
Cylindrospermopsin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-149-C025
25 µg
140.00 USD
ALX-350-149-C100
100 µg
210.00 USD
Product Specification
FORMULA:
C
15
H
21
N
5
O
7
S
MW:
415.4
CAS NUMBER:
143545-90-8
RTECS:
UV9104310
SOURCE/HOST:
Isolated from
Cylindrospermopsis raciborskii
.
PURITY:
≥95% (HPLC)
APPEARANCE:
Glassy solid.
SOLUBILITY:
Soluble in water, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC. HIGHLY IRRITANT.
Product Description
Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.
Product Specific Literature References
Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir:
P.R. Hawkins, et al.; Appl. Environ. Microbiol.
50
, 1292 (1985)
Abstract
;
Full Text
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii:
I. Ohtani, et al.; JACS
114
, 7941 (1992)
Full Text
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake:
P.R. Hawkins, et al.; Toxicon.
35
, 341 (1997)
Abstract
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity:
G.R. Shaw, et al.; Ther. Drug Monit.
22
, 89 (2000)
Abstract
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin:
I.R. Falconer & A.R. Humpage; Environ. Toxicol.
16
, 192 (2001)
Abstract
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin:
D.J. Griffiths and M.L. Saker; Environ. Toxicol.
18
, 78 (2003), Review
Abstract
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice:
M. Reisner, et al.; Toxicol. Sci.
82
, 620 (2004)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Uridine Derivatives Other Products
•
Protein Synthesis Other Products
•
Lipid Metabolism Other Products
•
Marine Natural Products
ALX-480-001
Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
SYNONYMS
ADP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-001-G001
1 g
45.00 USD
ALX-480-001-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
10
P
2
. 2Na
MW:
471.2 . 46.0
CAS NUMBER:
16178-48-6
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥
95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
SYNONYMS
ADP . K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-002-G001
1 g
45.00 USD
ALX-480-002-G005
5 g
180.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
10
P
2
. K
MW:
426.2 . 39.1
CAS NUMBER:
72696-48-1
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during prolonged storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-003
Revised 01-Dec-08
NADP . disodium salt
SYNONYMS
β-Nicotinamide Adenine Dinucleotide Phosphate
β-NADP
Coenzyme II
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-003-M050
50 mg
20.00 USD
ALX-480-003-M250
250 mg
55.00 USD
ALX-480-003-G001
1 g
160.00 USD
Product Specification
FORMULA:
C
21
H
26
N
7
O
17
P
3
. 2Na
MW:
741.4 . 46.0
CAS NUMBER:
1184-16-3
MERCK INDEX:
14:
6348
PURITY:
≥97%
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
50mg/ml soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Sensitive to alkaline.
HANDLING:
Keep cool and dry. Protect from light and moisture.
Further Categories Containing This Product:
Adenosine Derivatives Other Products
ALX-480-004
Revised 06-Aug-08
NADPH . tetrasodium salt
SYNONYMS
β-Nicotinamide Adenine Dinucleotide Phosphate (reduced form) . 4Na
β-NADPH . 4Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NAD+ Metabolism / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-004-M050
50 mg
58.00 USD
ALX-480-004-M250
250 mg
190.00 USD
ALX-480-004-G001
1 g
580.00 USD
Product Specification
FORMULA:
C
21
H
26
N
7
O
17
P
3
. 4Na
MW:
741.4 . 92.0
CAS NUMBER:
2646-71-1
PURITY:
≥95% (HPLC)
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Further Categories Containing This Product:
Adenosine Derivatives Other Products
ALX-480-006
Revised 22-Oct-08
8-Bromoguanosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-Br-cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-006-M010
10 mg
48.00 USD
ALX-480-006-M050
50 mg
145.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
7
P . Na
MW:
423.1 . 23.0
CAS NUMBER:
51116-01-9
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
PURITY DETAIL:
Low in fluorescent and colored impurities.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Activator of cGMP-dependent protein kinases (PKGs) 1α, 1β and type II and cGMP-gated ion channels (cGMP agonist). Has increased metabolic stability and membrane permeability compared to cGMP (Prod. No.
ALX-480-059
).
Product Specific Literature References
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP:
R.M. Rapoport, et al.; PNAS
79
, 6470 (1982)
Abstract
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices:
C.L. Boulton, et al.; Eur. J. Neurosci.
6
, 1528 (1994)
Abstract
Nitric oxide in skeletal muscle:
L. Kobzik, et al.; Nature
372
, 546 (1994)
Abstract
Nitric oxide. More jobs for that molecule:
S. Snyder; Nature
372
, 504 (1994)
Abstract
Further Categories Containing This Product:
PKG Activators
ALX-480-007
Revised 16-Feb-05
8-Bromoadenosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cAMP, 8-Br-, . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-007-M010
10 mg
42.00 USD
ALX-480-007-M050
50 mg
125.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
P . Na
MW:
407.1 . 23.0
CAS NUMBER:
76939-46-3
PURITY:
≥99% (low in fluorescent and colored impurities)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Has increased metabolic stability and membrane permeability compared with cAMP (Prod. No.
ALX-480-011
).
Further Categories Containing This Product:
PKA Activators
ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
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ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-012
Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
SYNONYMS
Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-012-M001
1 mg
110.00 USD
ALX-480-012-M005
5 mg
460.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
5
PS . C
6
H
16
N
MW:
345.5 . 101.0
CAS NUMBER:
151837-09-1
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase:
J.D. Rothermel; Biochem. J.
251
, 757 (1988)
Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates:
E. Butt, et al.; FEBS Lett.
263
, 47 (1990)
Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
:
L.Y. Wang, et al.; Science
253
, 1132 (1991)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
