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Items 11 of 11
ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.
Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC
50
~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid:
J.T. Sullivan, et al.; Planta Med.
44
, 175 (1982)
Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids:
R. Grazzini, et al.; BBRC
176
, 775 (1991)
Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus:
H. Muroi & I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
;
Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation:
Y. Sun, et al.; FEBS Lett.
580
, 4353 (2006)
Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
:
H. Muroi and I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition
:
R. Paramashivappa, et al.; J. Agric. Food Chem.
50
, 7709 (2002)
Abstract
Further Categories Containing This Product:
Prostaglandin Synthases / Related Products
•
Lipoxygenases / Related Products
•
Antibiotics Other Products
ALX-270-473
Revised 13-Jun-08
BIX 01294
SYNONYMS
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-270-473-M002
2 mg
190.00 USD
Product Specification
FORMULA:
C
28
H
38
N
6
O
2
MW:
490.6
CAS NUMBER:
935693-62-2
PURITY:
≥95%
APPEARANCE:
Light brown to brown solid.
SOLUBILITY:
Soluble in DMSO (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Selective and cell permeable inhibitor of G9a histone methyltransferase.
Product Specific Literature References
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase:
S. Kubicek, et al.; Mol. Cell
25
, 473 (2007)
Abstract
ALX-270-411
Revised 01-Apr-08
Butyrolactone 3
SYNONYMS
Gcn5 Inhibitor 1
MB-3
3-Methylene-4-hydroxycarbonyl-5-(1-propyl)-tetrahydrofuran-2-one
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-270-411-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
9
H
12
O
4
MW:
184.2
CAS NUMBER:
778649-18-6
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions in DMSO are stable for at least 2 months when stored at -20°C.
Product Description
Racemic. Inhibitor of human histone acetyltransferase Gcn5.
Product Specific Literature References
Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5
:
M. Biel, et al.; Angew. Chem. Int. Ed. Engl.
43
, 3974 (2004)
Abstract
ALX-201-283
Revised 18-Mar-08
CARM1 (human) (recombinant) (His)
SYNONYMS
Coactivator-associated Arginine Methyltransferase 1 (human) (recombinant) (His)
PRMT4 (human) (recombinant) (His)
Protein Arginine N-Methyltransferase 4 (human) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-201-283-C002
2 µg
280.00 USD
Product Specification
EC:
EC 2.1.1.125
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~50-100ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression:
M. Covic, et al.; EMBO J.
24
, 85 (2005)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q86X55:
CARM1 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-279
Revised 18-Mar-08
CREB Binding Protein (mouse) (recombinant) (His)
SYNONYMS
CBP (mouse) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
CREB & CREB Binding Protein / Related Products
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ALX-201-279-C002
2 µg
280.00 USD
Product Specification
EC:
EC 2.3.1.48
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~50-100ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P45481:
CREB Binding Protein (mouse)
Further Categories Containing This Product:
Histone Acetyl- & Methyl-Transferases / Related Products
•
Recombinant Proteins / Fusion Proteins
ALX-420-033
Revised 04-Jun-07
CTPB
SYNONYMS
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-420-033-M001
1 mg
40.00 USD
ALX-420-033-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
31
H
43
ClF
3
NO
2
MW:
554.1
CAS NUMBER:
586976-24-1
PURITY:
≥97% (
1
H-NMR)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent activator of p300 HAT (histone acetyltransferase), but not of PCAF (p300/CBP-associated factor) HAT activities.
General Literature References
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
ALX-201-280
Revised 18-Mar-08
GCN5 (human) (recombinant) (His)
SYNONYMS
GCN5L2 (human) (recombinant) (His)
Histone Acetyltransferase GCN5 (human) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-201-280-C002
2 µg
280.00 USD
Product Specification
EC:
EC 2.3.1.48
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~200-300ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92830:
GCN5 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-850-326
Revised 07-Jan-08
HAT Activity Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-850-326-KI01
1 Kit
413.00 USD
Product Specification
QUANTITY:
~100 tests.
KIT/SET CONTAINS:
2x HAT Assay Buffer
HAT Substrate I
HAT Substrate II
NADH Generating Enzyme
NE (Nuclear Extract 4 mg/ml)
HAT Reconstitution Buffer
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Images
Please click on thumbnails to enlarge.
Product Description
Histone acetyltransferases (HATs) have been implicated to play a crucial role in various cellular functions, such as gene transcription, differentiation, and proliferation. HAT Activity Colorimetric Assay Kit offers a convenient, nonradioactive system for a rapid and sensitive detection of HAT activity in mammalian samples. The kit utilizes active recombinant HAT as a positive control and acetyl-CoA as a cofactor. Acetylation of peptide substrate by active HAT releases the free form of CoA which then serves as an essential coenzyme for producing NADH. NADH can easily be detected spectrophotometrically upon reacting with a soluble tetrazolium dye. The detection can be continuous and suitable for kinetic studies. The kit provides a simple, straightforward protocol for a complete assay.
Product Specific Literature References
Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells:
P.A. Ruiz, et al.; J. Nutr.
137
, 1208 (2007)
Abstract
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-201-281
Revised 13-Aug-08
PCAF (mouse) (recombinant) (His)
SYNONYMS
P300/CBP-associated Factor (mouse) (recombinant) (His)
Histone Acetyltransferase PCAF (mouse) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-201-281-C020
20 µg
280.00 USD
Product Specification
EC:
EC 2.3.1.48
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~100-200ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9JHD1:
PCAF (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-210-287
Revised 13-Jan-05
Polyclonal Antibody to RbAp46 (human)
SYNONYMS
anti-Retinoblastoma Suppressor (Rb)-Associated Protein 46 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-210-287-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-13 (M
1
ASKEMFEDT
VEE
13
C) of human RbAp46 (retinoblastoma suppressor (Rb)-associated protein 46).
SPECIFICITY:
Recognizes human RbAp46. Detects a band of ~46kDa by Western blot.
APPLICATION:
Immunohistochemistry (1µg/ml)
Western Blot (0.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-166-006
.
Product Images
Please click on thumbnails to enlarge.
Product Description
Rb Associated Protein 46, RbAp46, is a nuclear protein that has been shown to interact directly with retinoblastoma protein, Rb, and is a component of the mSin3 corepressor complex as are the histone deactylase proteins (HDACs). RbAp46 shares about 75% sequence identity with the closely related RbAp48, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp46 has also been demonstrated to be up-regulated by the Wilms' tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-288
Revised 13-Jan-05
Polyclonal Antibody to RbAp48 (human)
SYNONYMS
anti-Retinoblastoma Suppressor (Rb)-Associated Protein 48 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-210-288-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-14 (M
1
ADKFAAFDDA
VEE
14
C) of human RbAp48 (retinoblastoma suppressor (Rb)-associated protein 48).
SPECIFICITY:
Recognizes human RbAp48. Detects a band of ~48kDa (and an unspecified band at ~60kDa) by Western blot.
APPLICATION:
Western Blot (1:2'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-166-007
.
Product Description
