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Other Natural Products - DNA Regulation / Transcription
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ALX-350-142 Revised 22-Aug-07
Rocaglamide I
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SYNONYMS 1-Acetyl-3’-hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-142-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C31H33NO9
MW: 563.6
CAS NUMBER: 189322-68-7
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
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Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-143 Revised 22-Aug-07
Rocaglamide J
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SYNONYMS Aglafolin
2-Methylrocaglate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-143-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C28H28O8
MW: 492.5
CAS NUMBER: 147059-47-0
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000) Abstract
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000) Abstract
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001) Abstract
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Natural Products - Immunomodulators • TNF-alpha & TNF Receptors Other Products • Other Natural Products - DNA Regulation / Transcription • Nuclear Factor of Activated T Cells [NF-AT] • NF-kB Pathway Inhibitors
 
 
ALX-350-135 Revised 04-Dec-07
Rocaglaol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-135-C100   100 µg 220.00 USD Add To Cart
Product Specification
FORMULA: C26H26O6
MW: 434.5
CAS NUMBER: 147059-46-9
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description

Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties. Induces apoptosis.
Product Specific Literature References
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000) Abstract
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells: Q. Mi, et al.; Anticancer Res. 26, 947 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. (Tokyo) 54, 1344 (2006) Abstract
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Natural Products - Immunomodulators • Nuclear Factor of Activated T Cells [NF-AT] • Other Natural Products - DNA Regulation / Transcription • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-380-243 Revised 08-Apr-08
Siomycin
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SYNONYMS Mutabilycin
Sporangiomycin
Antibiotic 6741-21
Mutabillicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-243-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C71H81N19O18S5
MW: 1648.9
CAS NUMBER: 12656-09-6
RTECS: VX0600000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4617.
PURITY: ≥95% (HPLC)
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Macrocyclic thiazole antibiotic with potent and selective antibacterial activity. Potent inhibitor of the oncogenic transcription factor forkhead box M1 (FoxM1) that downregulates protein and mRNA levels of FoxM1. Inhibits FoxM1 induced cell growth.

Product Specific Literature References
Studies on siomycin. I. Physicochemical properties of siomycins A, B and C: M. Ebata, et al.; J. Antibiot. 22, 364 (1969)
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1: S.K. Radhakrishnan, et al.; Cancer Res. 22, 364 (2006) Abstract; Full Text
Future roles for FoxM1 inhibitors in cancer treatments: G.R. Adami & H. Ye; Future Oncol. 3, 1 (2007) Abstract; Full Text
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins / Related Products • Other Natural Products - DNA Regulation / Transcription
 
 
ALX-350-004 Revised 08-Apr-08
Thapsigargin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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ALX-350-004-M001   1 mg 50.00 USD Add To Cart
ALX-350-004-M005   5 mg 200.00 USD Add To Cart
ALX-350-004-M010   10 mg 350.00 USD Add To Cart
ALX-350-004-M025   25 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C34H50O12
MW: 650.8
CAS NUMBER: 67526-95-8
MERCK INDEX: 14: 9272
PURITY: ≥95% (HPLC)
APPEARANCE: Clear colorless film.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and oxygen.
HAZARD: HIGHLY IRRITANT. HARMFUL.

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Product Description
Cell permeable tumor promoter by specific inhibition of the (sarco)endoplasmatic reticulum Ca2+-ATPase (SERCA). Inhibition of SERCA reveals a significant change in intracellular Ca2+ homeostasis and pH regulation in tumor cells. Does not increase inositol phosphates. Shows no effect on protein kinase C (PKC). Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis. Stimulates nitric oxide (NO) production, contributing to hepatocyte apoptosis.
Product Specific Literature References
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Thapsigargin, a Ca(2+)-ATPase inhibitor, depletes the intracellular Ca2+ pool and induces apoptosis in human hepatoma cells: A. Tsukamoto & Y. Kaneko; Cell Biol. Int. 17, 969 (1993) Abstract
The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin: Y. Furuya, et al.; Cancer Res. 54, 6167 (1994) Abstract
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang, et al.; Exp. Cell Res. 212, 84 (1994) Abstract
Role of EGR-1 in thapsigargin-inducible apoptosis in the melanoma cell line A375-C6: S. Muthukkumar, et al.; Mol. Cell. Biol. 15, 6262 (1995) Abstract; Full Text
Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells: X.M. Qi, et al.; Oncogene 15, 1207 (1997) Abstract
Signal transduction of thapsigargin-induced apoptosis in osteoblast: H.J. Chae, et al.; Bone 25, 453 (1999) Abstract
Nitric oxide is involved in apoptosis induced by thapsigargin in rat mesangial cells: A.M. Rodriguez-Lopez, et al.; Cell Physiol. Biochem. 9, 285 (1999) Abstract
Thapsigargin induces apoptosis in cultured human aortic smooth muscle cells: C. Peiro, et al.; J. Cardiovasc. Pharmacol. 36, 676 (2000) Abstract
Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells: B. Tombal, et al.; Prostate 43, 303 (2000) Abstract
Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes: G.G. Kovacs, et al.; Am. J. Physiol. Cell. Physiol. 289, C361 (2005) Abstract
Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture: N.K. Canova, et al.; Cell Biol. Toxicol. 23, 337 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Dissolving of 0.65mg Thapsigargin in 1ml gives a stock solution of 1mM.
General Literature References
Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin: O. Thastrup; Agents Actions 29, 8 (1990), (Review) Abstract
Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+ transport ATPases: G. Inesi and Y. Sagara; Arch. Biochem. Biophys. 298, 313 (1992), (Review) Abstract
Use of thapsigargin to study Ca2+ homeostasis in cardiac cells: T.B. Rogers, et al.; Biosci. Rep. 15, 341 (1995), (Review) Abstract
The sarcoplasmic reticulum Ca2+ pump: inhibition by thapsigargin and enhancement by adenovirus-mediated gene transfer: G. Inesi, et al.; Ann. NY Acad. Sci. 853, 195 (1998), (Review) Abstract; Full Text
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases: M. Treiman, et al.; TIPS 19, 131 (1998), (Review) Abstract
Further Categories Containing This Product:
Ca2+-ATPase / Related Products • Endoplasmatic Reticulum Stress • Other Natural Products - DNA Regulation / Transcription • Carcinogens & Tumor Promoters Other Products • Natural Products - ATPase Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Nuclear Envelope & Nuclear Transport • Autophagy Other Products
 
 
ALX-350-261 Revised 07-Oct-08
Trichodion
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-261-C100   100 µg 85.00 USD Add To Cart
ALX-350-261-C500   500 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C12H14O5
MW: 238.2
SOURCE/HOST: Isolated from Trichosporiella sp.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cytotoxic. Inhibits NF-κB (IC50=42-84µM), AP-1 (IC50=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.
Product Specific Literature References
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000) Abstract; Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • COX Inhibitors • Other Natural Products for Inflammation Research
 
 
ALX-350-280 Revised 07-Oct-08
Xanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-280-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
CAS NUMBER: 569-83-5, 6754-58-1
SOURCE/HOST: Isolated from hops (Humulus lupulus).
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY: Identity determined by NMR.

Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors / Related Products • Cell Differentiation • Hypoxia-inducible Factor [HIF] / Related Products • Chalcones • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Respiratory Chain Other Products • Obesity & Diabetes Other Products • Natural Products - Antitumor Reagents • VEGFs • Lipid Metabolism Other Products
 
 
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