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ALX-201-157
Revised 23-Feb-07
Histone H1.3 (human) (recombinant)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-157-M001
1 mg
170.00 USD
Product Specification
MW:
~22kDa.
SOURCE/HOST:
Produced in
E. coli.
PURITY:
≥95% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or aqueous solutions.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P16402:
Histone H1.3 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-159
Revised 08-Dec-04
Histone H1.5 (human) (recombinant)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-159-M001
1 mg
170.00 USD
Product Specification
MW:
~23kDa.
SOURCE/HOST:
Produced in
E. coli.
PURITY:
≥98% (SDS-PAGE, HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or aqueous solutions.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-158-001
Revised 28-Feb-06
Histone H1-7 Substrate
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
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ALX-158-001-M001
1 mg
70.00 USD
ALX-158-001-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Lys-Ala-Ser-Gly-Pro-OH
FORMULA:
C
31
H
58
N
14
O
9
MW:
770.9
PURITY:
≥98%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA). The peptide is derived from the phosphorylation site (Ser
38
) in calf thymus histone H1.
Product Specific Literature References
Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase:
A.H. Pomerantz, et al.; PNAS
74
, 4261 (1977)
Abstract
Further Categories Containing This Product:
Peptides
•
PKA Substrates
ALX-158-003
Revised 04-Jul-03
Histone H2B (29-35)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
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Format:
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ALX-158-003-M001
1 mg
50.00 USD
ALX-158-003-M005
5 mg
200.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Arg-Ser-Arg-Lys-Glu-OH
FORMULA:
C
38
H
74
N
18
O
11
MW:
959.1
PURITY:
≥97%
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to residues 29-35 of histone H2B. For the corresponding alanine-for-serine substituted peptides see Prod. No.
ALX-158-002
and Prod. No.
ALX-158-004
.
Product Specific Literature References
Comparison of the substrate specificity of adenosine 3':5'- monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to phosphorylation sites in histone H2B:
D.B. Glass & E.G. Krebs; J. Biol. Chem.
254
, 9728 (1979)
Abstract
;
Full Text
Further Categories Containing This Product:
PKG Substrates
•
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
Peptides
ALX-158-002
Revised 28-Feb-06
[Ala32]-Histone H2B (29-35)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-158-002-M001
1 mg
75.00 USD
ALX-158-002-M005
5 mg
300.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH
FORMULA:
C
38
H
74
N
18
O
10
MW:
943.1
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of cGMP-dependent protein kinase, derived by a serine-to-alanine substitution at position 32 of histone H2B (29-35). For the corresponding unsubstituted histone fragment see Prod. No.
ALX-158-003
.
Product Specific Literature References
D.B. Glass & M.D. Miller; Fed. Proc.
39
, 867 (1980)
Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors:
D.B. Glass; Biochem. J.
213
, 159 (1983)
Abstract
Further Categories Containing This Product:
Peptides
•
PKG Inhibitors
ALX-158-004
Revised 13-Jan-05
[Ala34]-Histone H2B (29-35)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
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ALX-158-004-M001
1 mg
60.00 USD
ALX-158-004-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH
FORMULA:
C
35
H
67
N
17
O
11
MW:
902.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for cGMP-dependent protein kinase. For the corresponding unsubstituted histone fragment see Prod. No.
ALX-158-003
.
Product Specific Literature References
Phosphorylation by guanosine 3':5'-monophosphate-dependent protein kinase of synthetic peptide analogs of a site phosphorylated in histone H2B:
D.B. Glass & E.G. Krebs; J. Biol. Chem.
257
, 1196 (1982)
Abstract
;
Full Text
Further Categories Containing This Product:
PKG Substrates
•
Peptides
ALX-201-176
Revised 17-Nov-08
Histone H2AX (human) (recombinant)
SYNONYMS
Histone H2AFX (human) (recombinant)
Histone H2A.X (human) (recombinant)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
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Quantity:
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ALX-201-176-M001
1 mg
290.00 USD
ALX-201-176-M005
5 mg
1'160.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥98% (SDS-PAGE; HPLC)
FORMULATION:
Lyophilized.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
The phosphorylation status of this product was not analyzed (it was not determined whether the product contains Ser
139
-phosphorylated histone γ-H2AX).
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-202-052
Revised 17-Jun-05
Histone Deacetylase (rat)
SYNONYMS
HDAC (rat)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDACs
Ordering Information
Product Numbers:
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ALX-202-052-L002
2 ml
295.00 USD
Product Specification
SOURCE/HOST:
Isolated from rat liver.
CONCENTRATION:
FORMULATION:
Liquid. In 1.4mM NaH
2
PO
4
, containing 18.6mM Na
2
HPO
4
, pH 7.9, 0.25mM EDTA, ~700mM sodium chloride, 10% (v/v) glycerol and 10mM 2-mercaptoethanol.
SPECIFIC ACTIVITY:
~100U/ml. One unit is defined as the amount of enzyme that deacetylates 1pmol of substrate per min. at 37°C [1].
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. Protect from light.
Product Specific Literature References
Improvement and validation of the fluorescence-based histone deacetylase assay using an internal standard
:
K. Hoffmann, et al.; Arch. Pharm.
334
, 248 (2001)
Abstract
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-850-294
Revised 17-Dec-07
Histone Deacetylase Colorimetric Assay Kit
SYNONYMS
HDAC Colorimetric Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Kits & Sets
Ordering Information
Product Numbers:
Format:
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ALX-850-294-KI01
1 Kit
399.00 USD
Product Specification
QUANTITY:
~100 tests
KIT/SET CONTAINS:
500µl HDAC Substrate (Boc-Lys(Ac)-pNA)
1.0ml 10X HDAC Assay Buffer
1.0ml Lysine Developer
10µl HDAC Inhibitor (Trichostatin A)
50µl HeLa Nuclear Extract
20µl Deacetylated Standard (Boc-Lys-pNA)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Description
Kit provides a fast and colorimetric-based method that eliminates radioactivity, extractions, or chromatography, as used in traditional assays. The new procedure requires only two easy steps, both performed in the same microtiter plate. First, the histone deacetylase (HDAC) colorimetric substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity. Deacetylation sensitizes the substrate, so that in the second step, treatment with the lysine developer produces a chromophore. The chromophore can be easily analyzed at 400 or 405nm using an ELISA plate reader or a spectrometer. The assay is well suited for high throughput screening applications. HDAC inhibitors, substrates, and antibodies are also available separately.
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-850-290
Revised 05-Dec-05
Histone Deacetylase Fluorometric Assay Kit
SYNONYMS
HDAC Fluorometric Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Kits & Sets
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-850-290-KI01
1 Kit
357.00 USD
Product Specification
QUANTITY:
100 tests.
KIT/SET CONTAINS:
500µl HDAC Substrate (Boc-Lys(Ac)-AMC)
1ml 10x HDAC Assay Buffer
1ml Lysine Developer
10µl HDAC Inhibitor (Trichostatin A)
10µl HeLa Nuclear Extract
20µl Deacetylated Standard (Boc-Lys-AMC)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Description
Kit provides a fast and fluorescence-based method that eliminates radioactivity, extractions, or chromatography, as used in traditional assays. The new procedure requires only two easy steps, both performed in the same microtiter plate. First, the histone deacetylase (HDAC) fluorometric substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity. Deacetylation sensitizes the substrate, so that in the second step, treatment with the lysine developer produces a fluorophore. The fluorophore can be easily analyzed using a fluorescence plate reader or a fluorometer (Ex(max): 380nm; Em(max): 460nm). The assay is well suited for high throughput screening applications. HDAC inhibitors, substrates, and antibodies are also available separately.
Product Specific Literature References
Histone acetylation in chromatin structure and transcription
:
M. Grunstein; Nature
389
, 349 (1997)
Abstract
Acetylation and chromosomal functions
:
W.L. Cheung, et al.; Curr. Opin. Cell Biol.
12
, 326 (2000)
Abstract
The language of covalent histone modifications
:
B.D. Strahl & C.D. Allis; Nature
403
, 41 (2000)
Abstract
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-270-382
Revised 04-Feb-05
ITSA1
SYNONYMS
N-(1
H
-Benzotriazol-1-yl)-2,4-dichlorobenzamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Other Products
Ordering Information
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ALX-270-382-M005
5 mg
30.00 USD
ALX-270-382-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
13
H
7
Cl
2
N
3
O
MW:
292.1
PURITY:
≥95% (HPLC)
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Packaged under inert gas.
HAZARD:
MAY BE CARCINOGENIC. TOXIC.
Product Description
Cell permeable benzotriazole amide that counteracts and complements histone and tubulin deacetylase (HDAC and TDAC) inhibitors in elucidating mechanisms of inhibition and the role of acetylation in various cellular responses such as transcription, differentiation, cell cycle progression, and apoptosis. Does not modify histone acetyltransferases (HATs) or the levels of HDAC. Suppresses the anti-proliferative effects of trichostatin A (Prod. No.
ALX-380-068
).
Product Specific Literature References
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
:
S.J. Haggarty, et al.; Chem. Biol.
10
, 383 (2003)
Abstract
Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation
:
K.M. Koeller, et al.; Chem. Biol.
10
, 397 (2003)
Abstract
Related Products
ALX-380-068
Trichostatin A
ALX-270-297
Revised 06-Dec-04
M344
SYNONYMS
4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)-benzamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-297-M001
1 mg
95.00 USD
ALX-270-297-M005
5 mg
390.00 USD
Product Specification
FORMULA:
C
16
H
25
N
3
O
3
