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ALX-210-487
Revised 27-Nov-08
Polyclonal Antibody to Sirtuin 2 (human)
SYNONYMS
anti-Sirt2 (human) PAb
anti-SIR2-like Protein 2 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-487-C100
100 µg
340.00 USD
Product Specification
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human sirtuin 2.
SPECIFICITY:
Recognizes human sirtuin 2.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for up to 6 months when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
NAD+ Metabolism / Related Products
•
Polyclonal Antibodies
•
p53 Other Products
ALX-210-253
Revised 12-Jul-07
Polyclonal Antibody to SMRT (human)
SYNONYMS
anti-Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
SMRT & N-CoR / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-253-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1302-1495 of human SMRT (silencing mediator of retinoic acid and thyroid hormone receptor).
SPECIFICITY:
Recognizes human SMRT. Detects a band of ~250kDa by Western blot.
APPLICATION:
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. SMRT (silencing mediator of retinoic acid & thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-285
Revised 30-Oct-06
Polyclonal Antibody to SMRT (human)
SYNONYMS
anti-Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
SMRT & N-CoR / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-285-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human SMRT (silencing mediator of retinoic acitd and thyroid hormone receptor) (aa 95-565).
SPECIFICITY:
Recognizes human SMRT. Detects a band of ~250kDa by Western blot.
APPLICATION:
Western Blot (4µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-283
Revised 06-Apr-06
Polyclonal Antibody to SRC-1
SYNONYMS
anti-Steroid Receptor Coactivator-1 PAb
anti-NCOA1 PAb
anti-Nuclear Receptor Coactivator 1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Receptor Coactivators / Related Products
Ordering Information
Product Numbers:
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ALX-210-283-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 8-24 (S
8
SDPANPDSHKRK
GSPC
24
) of human SRC-1 (steroid receptor coactivator-1).
SPECIFICITY:
Recognizes human and mouse SRC-1. Detects a band of ~165kDa and an unspecific band of ~40kDa by Western blot.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry (frozen sections (1µg/ml))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-167-020
.
Product Images
Please click on thumbnails to enlarge.
Product Description
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-559
Revised 31-Oct-06
Polyclonal Antibody to TetR
SYNONYMS
anti-Tetracycline Repressor PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Transcriptional Repressors & Corepressors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-559-R100
100 µl
280.00 USD
Product Specification
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum in PBS containing 50% glycerol and traces of sodium azide.
IMMUNOGEN:
Recombinant TetR (tetracycline repressor).
SPECIFICITY:
Recognizes the TetR portion of bait fusion protein in the yeast two-hybrid system. Detects a band of ~37kDa by Western blot.
APPLICATION:
Western Blot (1:500)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
This antibody can also be excellently used in RNAi expression systems relying on TetR regulation, by verifying the TetR expression levels. Double-check your cell-line if it is suitable for inducible, tet-repressor dependent RNAi expression.
Further Categories Containing This Product:
Gene Expression & Analysis Other Products
•
Polyclonal Antibodies
ALX-210-471
Revised 16-Aug-07
Polyclonal Antibody to Th-POK (human)
SYNONYMS
anti-T-helper-inducing POZ/Krueppel-like Factor (human) PAb
anti-Zinc Finger Protein 67 Homolog (human) PAb
anti-ZFP67 (human) PAb
anti-Zinc Finger and BTB Domain-containing Protein 7B (human) PAb
anti-ZBTB7B human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Zinc Finger Proteins / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-471-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human Th-POK.
SPECIFICITY:
Recognizes human Th-POK.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry
(paraffin sections (5µg/ml))
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-163
Revised 14-Nov-05
Polyclonal Antibody to Thyroid Hormone Receptor α-1
SYNONYMS
anti-TRα-1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-163-R100
100 µl
524.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 403-410 (E
403
VFEDQEV
410
) of human TRα-1 (thyroid hormone receptor α-1).
SPECIFICITY:
Recognizes human and chicken TRα-1. Detects a band of ~48kDa by Western blot. Does not cross-react with TRα-2 or TRβ-1.
APPLICATION:
Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-165
Revised 21-Dec-06
Polyclonal Antibody to Thyroid Hormone Receptor β-1
SYNONYMS
anti-TRβ-1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-165-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 67-86 (I
67
FHLDHDDVNDQSVSSAQTF
86
) of human TRβ-1 (thyroid hormone receptor β-1).
SPECIFICITY:
Recognizes human and rat TRβ-1. Detects a band of ~55kDa by Western blot. Does not cross-react with TRα-1 or TRα-2.
APPLICATION:
Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-763
Revised 14-Dec-05
Polyclonal Antibody to Topoisomerase IIα (human)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Topoisomerase Antibodies
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-763-C500
500 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified IgG.
FORMULATION:
Liquid. In 10mM PBS, pH 7.4, containing 0.2% BSA and 0.09% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1513-1530 (R
1513
AKKPIKYLEESDEDDLF
1530
) of C-terminal human topoisomerase IIα.
SPECIFICITY:
Recognizes human topoisomerase IIα. Detects a band of ~170kDa by Western blot. Does not cross-react with topoisomerase IIβ or I.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation (use Protein A; 10µg/mg protein lysate)
Western Blot (excellent) (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Description
Topoisomerase IIα plays important roles in the synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G
2
- and M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells. Note: Ki67 is also present in G
1
-phase.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-462
Revised 10-Apr-08
Polyclonal Antibody to TRB-3 (human)
SYNONYMS
anti-Tribbles Homolog 3 (human) PAb
anti-Neuronal Cell Death-inducible Putative Kinase (human) PAb
anti-p65-interacting Inhibitor of NF-κB (human) PAb
anti-SINK (human) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Modulators
Ordering Information
Product Numbers:
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ALX-210-462-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 112-125 (A
112
RLPPHKHVARPTE
125
) of human TRB-3 (tribbles homolog 3).
SPECIFICITY:
Recognizes human TRB-3.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Immunohistochemistry
(paraffin sections(1:500))
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1-2 weeks when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPARγ, a master regulator of adipocyte differentiation, and to control adipogenesis.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
PPAR Other Products
•
PI(3)K-Akt-mTOR Pathway Other Products
•
MAPK Pathway Other Products
•
Transcription Regulators Other Products
•
Polyclonal Antibodies
ALX-210-108
Revised 24-Feb-05
Polyclonal Antibody to Vitamin D3 Receptor
SYNONYMS
anti-VDR PAb
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-108-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 395-413 (E
395
EHSKQYRCLS
FQPECSMK
413
) of C-terminal human VDR (vitamin D
3
receptor).
SPECIFICITY:
Recognizes human, mouse and rat VDR. Detects a band of ~53kDa by Western blot.
APPLICATION:
Gel Supershift Assays
Immunoprecipitation
Western Blot (1:100; For better results we recommend Prod. No.
ALX-804-021
for Western blot applications)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Related Products
ALX-804-021
Monoclonal Antibody to Vitamin D
3
Receptor (9A7)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-304
Revised 27-Dec-06
Polyclonal Antibody to XRCC1 (human)
