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PARG / Related Products
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP] / Related Products > PARG / Related Products
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ALX-480-094 Revised 07-Oct-08
ADP-HPD . ammonium salt . dihydrate
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SYNONYMS Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH4 . 2H2O
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-094-C060   60 µg 188.00 USD Add To Cart
Product Specification
FORMULA: C15H23N6O12P2 . NH4 . 2H2O
MW: 541.3 . 18.0 . 36.0
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.

Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995) Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995) Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage: S. Vispe, et al.; PNAS 97, 9886 (2000) Abstract; Full Text
Further Categories Containing This Product:
DNA Repair Other Products • PARG / Related Products
 
 
ALX-270-418 Revised 16-Jun-08
Gallotannin
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SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • PARG / Related Products • DNA Repair Other Products • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids
 
 
ALX-202-045 Revised 19-Jul-06
PARG (bovine)
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SYNONYMS Poly(ADP-ribose) glycohydrolase (bovine)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARG / Related Products
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ALX-202-045-UC01   0.1 U 375.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from calf thymus.
QUANTITY: 100µl
CONCENTRATION:     
PURITY: Purified by substrate chromatography. The enzyme is composed of two major bands at 74kDa and 59kDa
SPECIFIC ACTIVITY: ~10’000U/mg protein. 1U is defined as the amount of enzyme that hydrolyzes 1nmol of poly(ADP-ribose) per min. at 37°C.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase: H. Thomassin, et al.; Nucl. Acid Res. 18, 4691 (1990) Abstract
Poly(ADP-ribosyl)ation of chromatin in an in vitro poly(ADP-ribose)-turnover system: H. Thomassin, et al.; Biochim. Biophys. Acta 1137, 171 (1992) Abstract
Mode of action of poly(ADP-ribose) glycohydrolase: G. Brochu, et al.; Biochim. Biophys. Acta 1219, 342 (1994) Abstract
General Information
For further dilution use the following enzyme dilution buffer: 50mM KPO4, pH 7.5, 50mM KCl, 10 mM β-mercaptoethanol, 10% glycerol, 1mM DTT, 0.1% Triton.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O02776: Poly(ADP-ribose) glycohydrolase (bovine)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
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