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Transcription Factors / Related Products
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ALX-804-818 Revised 01-Mar-07
Monoclonal Antibody to NALP3 (human) (Nalpy3-a)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 3 (human) MAb (Nalpy3-a)
anti-Cryopyrin (human) MAb (Nalpy3-a)
anti-Cold Autoinflammatory Syndrome 1 Protein (human) MAb (Nalpy3-a)
anti-PYPAF1 (human) MAb (Nalpy3-a)
anti-PYRIN-containing APAF1-like Protein 1 (human) MAb (Nalpy3-a)
anti-CIAS1 (human) MAb (Nalpy3-a)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-818-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nalpy3-a
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human NALP3 (NACHT-, LRR- and PYD-containing protein 3) (pyrin domain).
SPECIFICITY: Recognizes human NALP3. Detects endogenous protein by ICC and WB.
APPLICATION: Immunocytochemistry (1:100)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation: M. Chamaillard, et al.; Cell. Microbiol. 5, 581 (2003) Abstract; Full Text
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties: W. O'Connor, Jr., et al.; J. Immunol. 171, 6329 (2003) Abstract
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases: F. Martinon and J. Tschopp; Cell 117, 561 (2004) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-819 Revised 26-Oct-07
Monoclonal Antibody to NALP3 (human) (Nalpy3-b)
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SYNONYMS anti-NACHT-, LRR- and PYD-containing Protein 3 (human) MAb (Nalpy3-b)
anti-Cryopyrin (human) MAb (Nalpy3-b)
anti-Cold Autoinflammatory Syndrome 1 Protein (human) MAb (Nalpy3-b)
anti-PYPAF1 (human) MAb (Nalpy3-b)
anti-PYRIN-containing APAF1-like Protein 1 (human) MAb (Nalpy3-b)
anti-CIAS1 (human) MAb (Nalpy3-b)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Inflammasome
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-819-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nalpy3-b
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human NALP3 (NACHT-, LRR- and PYD-containing protein 3) (pyrin domain).
SPECIFICITY: Recognizes human NALP3. Detects endogenous protein by IP and WB.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation (1:50)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder: L. Agostini, et al.; Immunity 20, 319 (2004) Abstract
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response: J.A. Kummer, et al.; J. Histochem. Cytochem. 55, 443 (2007) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation: M. Chamaillard, et al.; Cell. Microbiol. 5, 581 (2003) Abstract; Full Text
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties: W. O'Connor, Jr., et al.; J. Immunol. 171, 6329 (2003) Abstract
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases: F. Martinon and J. Tschopp; Cell 117, 561 (2004) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-022 Revised 26-Sep-08
Monoclonal Antibody to NF-ATc1 (7A6)
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SYNONYMS anti-Nuclear Factor of Activated T Cells, Cytoplasmic 1 MAb (7A6)
anti-NFAT2 MAb (7A6)
anti-NFATC MAb (7A6)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Nuclear Factor of Activated T Cells [NF-AT]
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-022-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 7A6
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human NF-ATc1 (nuclear factor of activated T cells, cytoplasmic 1) (aa 1-654).
SPECIFICITY: Recognizes human, mouse, rat and monkey NF-ATc1. Detects a band of ~105kDa by Western blot. Does not cross-react with NF-ATc2.
APPLICATION: Flow Cytometry
Gel Supershift Assay
Immunocytochemistry (1:250)
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity: S.N. Ho, et al.; J. Biol. Chem 270, 19898 (1995) Abstract; Full Text
Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells: K.M. Latinis, et al.; J. Biol. Chem. 272, 31427 (1997) Abstract; Full Text
Expression of NFAT-family proteins in normal human T cells: L. Lyakh, et al.; Mol. Cell. Biol. 17, 2475 (1997) Abstract; Full Text
The calcineurin-NFAT pathway and muscle fiber-type gene expression: S.J. Swoap, et al.; Am. J. Physiol. Cell Physiol. 279, C915 (2000) Abstract; Full Text
The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements: H.P. Kim & W.J. Leonard; EMBO J. 21, 3051 (2002) Abstract; Full Text
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity: T.R. Jan, et al.; Mol. Pharmacol. 61, 446 (2002) Abstract; Full Text
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation: S. Diehl, et al.; J. Exp. Med. 196, 39 (2002) Abstract; Full Text
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells: C. Pfeifhofer, et al.; J. Exp. Med. 197, 1525 (2003) Abstract; Full Text
Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells: A. Kerstan & T. Hunig; J. Immunol. 172, 1341 (2004) Abstract
Active protein kinase B regulates TCR responsiveness by modulating cytoplasmic-nuclear localization of NFAT and NF-kappa B proteins: A.K. Patra, et al.; J. Immunol. 172, 4812 (2004) Abstract
IL-4-Induced GATA-3 Expression Is a Time-Restricted Instruction Switch for Th2 Cell Differentiation: N. Seki, et al.; J. Immunol. 172, 6158 (2004) Abstract
Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production: J.L. Cannon and J.K. Burkhardt; J. Immunol. 173, 1658 (2004) Abstract; Full Text
Role of NFAT proteins in IL13 gene transcription in mast cells: S. Monticelli, et al.; J. Biol. Chem. 279, 36210 (2004) Abstract; Full Text
Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms: J. Barlic, et al.; J. Biol. Chem. 279, 48520 (2004) Abstract; Full Text
Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis: T. Minami, et al.; J. Biol. Chem. 279, 50537 (2004) Abstract; Full Text
NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching: K.J. McCullagh, et al.; PNAS 101, 10590 (2004) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways: B.M. Scicchitano, et al.; Mol. Biol. Cell 16, 3632 (2005) Abstract; Full Text
Calcium-dependent activation of interleukin-21 gene expression in T cells: H.P. Kim, et al.; J. Biol. Chem. 280, 25291 (2005) Abstract; Full Text
Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model: Z. Liu, et al.; J. Biol. Chem. 280, 14700 (2005) Abstract; Full Text
Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3: W. Wu, et al.; J. Biol. Chem. 281, 10682 (2006) Abstract; Full Text
Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers: T. Shen, et al.; Mol Biol Cell 17, 1570 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Note: Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-215 Revised 24-Feb-06
Monoclonal Antibody to NF-ATc2 (25A10.D6.D2)
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SYNONYMS anti-Nuclear Factor of Activated T Cells, Cytoplasmic 2 MAb (25A10.D6.D2)
anti-NFAT1 MAb (25A10.D6.D2)
anti-NFATP MAb (25A10.D6.D2)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Nuclear Factor of Activated T Cells [NF-AT]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-215-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 25A10.D6.D2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 51-69 (A51ISSPSGLAYPDD
VLDYGL69) of mouse nuclear factor of activated T cells, cytoplasmic 2 (NF-ATc2) conserved in all three isoforms A, B and C.
SPECIFICITY: Recognizes human, mouse and rat NF-ATc2. Detects bands of ~140kDa (phosphorylated NF-ATc2 in resting immune cells) and ~120kDa (fully-dephosphorylated NF-ATc2 in stimulated cells) by Western blot. Does not cross-react with NF-ATc1.
APPLICATION: Gel Supershift Assays
Immunocytochemistry (1µg/ml)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-163-009.
Product Specific Literature References
The calcineurin-NFAT pathway and muscle fiber-type gene expression: S.J. Swoap, et al.; Am. J. Physiol. Cell Physiol. 279, C915 (2000) Abstract; Full Text
Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain: S. Plyte, et al.; J. Biol. Chem. 276, 14350 (2001) Abstract; Full Text
The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements: H.P. Kim & W. Leonard; EMBO J. 21, 3051 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Note: Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-043 Revised 04-Dec-04
Monoclonal Antibody to NF-κB (human) (NF3A11)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Transcription Factors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-043-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: NF3A11
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: 100µg of protein G purified antibody in 100µl Tris/Glycine buffer containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human NF-κB (p50 subunit).
SPECIFICITY: Recognizes p50 subunit of human NF-κB (epitope in the region aa 191-197).
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-044 Revised 04-Dec-04
Monoclonal Antibody to NF-κB (human) (NF5E6)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-044-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: NF5E6
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein G purified antibody in Tris/Glycine buffer containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human NF-κB (p50 subunit).
SPECIFICITY: Recognizes p50 subunit of human NF-κB (epitope in the region aa 1-15).
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-361 Revised 09-May-07
Monoclonal Antibody to NF-κB (p65) (112A1021)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-361-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 112A1021
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 526-539 of human NF-κB (p65 subunit) .
SPECIFICITY: Recognizes human and mouse NF-κB (p65 subunit ). Detects a band of ~65kDa by Western blot.
APPLICATION: Flow Cyctometry (2.5µg/ml) (see [1])
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Specific Literature References
[1] Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases: M. Wittmann, et al.; J. Invest. Dermatol. 124, 1225 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-816 Revised 08-Jan-07
Monoclonal Antibody to Promyelocytic Leukemia Protein (mouse) (36-1-104)
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SYNONYMS anti-PML (mouse) MAb (36-1-104)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Transcription Factors Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-816-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 36-1-104
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse PML (promyelocytic leukemia protein) (aa 1-581).
SPECIFICITY: Recognizes mouse PML. Does not cross-react with human PML. Detects endogenous protein by ICC, IP and WB.
APPLICATION: Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:500-1:1'000)
Functional Application: Electrophoretic Mobility Shift Assay (EMSA).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt if stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
PML is a direct p53 target that modulates p53 effector functions: E. de Stanchina, et al.; Mol. Cell 13, 523 (2004) Abstract
PML regulates p53 stability by sequestering Mdm2 to the nucleolus: R. Bernardi, et al.; Nat. Cell Biol. 6, 665 (2004) Abstract
Identification of a tumour suppressor network opposing nuclear Akt function: L.C. Trotman, et al.; Nature 441, 523 (2006) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
PML is induced by oncogenic ras and promotes premature senescence: G. Ferbeyre, et al.; Genes Dev. 14, 2015 (2000) Abstract
The role of PML in tumor suppression: P. Salomoni and P.P. Pandolfi; Cell 108, 165 (2002) Abstract
PML regulates p53 stability by sequestering Mdm2 to the nucleolus: R. Bernardi, et al.; Nat. Cell Biol. 6, 665 (2004) Abstract
PML nuclear bodies and apoptosis: Y. Takahashi, et al.; Oncogene 23, 2819 (2004) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-849 Revised 16-Aug-07
Monoclonal Antibody to RIG-I (Alme-1)
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SYNONYMS anti-RIG-1 MAb (Alme-1)
anti-Retinoic Acid-inducible Gene 1 Protein MAb (Alme-1)
anti-DEAD-box Protein 58 MAb (Alme-1)
anti-Probable ATP-dependent RNA Helicase DDX58 MAb (Alme-1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-849-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Alme-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.