ALEXIS Biochemicals: Gelonin

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ALX-351-001

Revised 08-Apr-08

Paclitaxel
SYNONYMS	Taxol^®
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-001-M001		1 mg	20.00 USD
ALX-351-001-M005		5 mg	50.00 USD
ALX-351-001-M025		25 mg	150.00 USD

Product Specification

FORMULA:	C₄₇H₅₁NO₁₄
MW:	853.9
CAS NUMBER:	33069-62-4
MERCK INDEX:	14: 6982
RTECS:	DA8340700
SOURCE/HOST:	Isolated from Taxus brevifolia.
PURITY:	≥98%
APPEARANCE:	Off-white crystalline powder.
SOLUBILITY:	Soluble in acetonitrile, DMSO or methanol; sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.
HAZARD:	MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.
IDENTITY:	Determined by IR.

Product Description

Antitumor agent. Binds to tubulin. Promotes assembly and inhibits disassembly of microtubules. Blocks the cell cycle at the mitotic phase and induces apoptosis. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CDKs) and the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) are involved in paclitaxel-induced apoptosis.

Product Specific Literature References

CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells: Y.D. Yoo, et al.; Clin Cancer Res 4, 3063 (1998) Abstract
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) Abstract
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang, et al.; Cancer 88, 2619 (2000) Abstract
Disruption of Cell Adhesion and Caspase-Mediated Proteolysis of beta- and gamma-Catenins and APC Protein in Paclitaxel-Induced Apoptosis:: Y.H. Ling, et al.; Mol. Pharmaco. 59, 593 (2001) Abstract; Full Text
Taxol: biosynthesis, molecular genetics, and biotechnological applications: S. Jennewein and R. Croteau; Appl. Microbiol. Biotechnol. 57, 13 (2001) Abstract
Chemistry and chemical biology of taxane anticancer agents: M.L. Miller and I. Ojima; Chem. Rec. 1, 195 (2001) Abstract
Paclitaxel and its formulations: A.K. Singla, et al.; Int. J. Pharm. 235, 179 (2002) Abstract
Paclitaxel in cancer therapy: T.M. Mekhail and M. Markman; Expert. Opin. Pharmacother. 3, 755 (2002) Abstract
Taxol reactions: K.S. Price and M.C. Castells; Allergy Asthma Proc. 23, 205 (2002) Abstract
The chemistry of taxol and related taxoids: D.G. Kingston, et al.; Fortschr. Chem. Org. Naturst. 84, 53 (2002) Abstract
Overcoming multidrug resistance in taxane chemotherapy: R. Geney, et al.; Clin. Chem. Lab. Med. 40, 918 (2002) Abstract
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action: M. Abal, et al.; Curr. Cancer Drug Targets 300, 193 (2003) Abstract
Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer: D. Simpson & G.L. Plosker; Drugs 64, 1839 (2004), Review Abstract
Paclitaxel for AIDS-associated Kaposi’s sarcoma: T. Dhillon, et al.; Expert Rev. Anticancer Ther. 5, 215 (2005), Review Abstract
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo: P. Wagner, et al.; Cell Cycle 4, 1149 (2005), Review Abstract

Further Categories Containing This Product:

ALX-351-005

Revised 07-Jan-08

Baccatin III
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-005-M005		5 mg	85.00 USD
ALX-351-005-M025		25 mg	360.00 USD

Product Specification

FORMULA:	C₃₁H₃₈O₁₁
MW:	586.6
CAS NUMBER:	27548-93-2
SOURCE/HOST:	Semisynthetic.
PURITY:	≥95%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or 100 % ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description

Starting material for the synthesis of taxol analogs. Shows antitumor properties.

Product Specific Literature References

Recent advances in the chemistry of taxol: D.G. Kingston; J. Nat. Prod. 63, 726 (2000) Abstract

Further Categories Containing This Product:

Taxol / Related Products

ALX-351-006

Revised 07-Jan-08

Baccatin III, 10-Deacetyl-
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-351-006-M005		5 mg	190.00 USD
ALX-351-006-M025		25 mg	590.00 USD

Product Specification

FORMULA:	C₂₉H₃₆O₁₀
MW:	544.6
CAS NUMBER:	32981-86-5
SOURCE/HOST:	Isolated from Taxus baccata.
PURITY:	≥95%
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description

Intermediate for the preparation of taxol analogs.

Product Specific Literature References

Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract

Further Categories Containing This Product:

ALX-380-097

Revised 23-Apr-08

Mithramycin A
SYNONYMS	Mithracin Aureolic acid Aurelic acid Plicamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-097-M001		1 mg	30.00 USD
ALX-380-097-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₅₂H₇₆O₂₄
MW:	1085.2
CAS NUMBER:	18378-89-7
MERCK INDEX:	14: 7536
RTECS:	PZ2800000
SOURCE/HOST:	Isolated from Streptomyces argillaceus.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Antineoplastic and immunosuppressive antibiotic. Inhibits transcription and protein synthesis. Substrate of P-glycoprotein (Pgp) in multidrug resistant (MDR) cancer cells. Binds to DNA in native chromatin. DNA-binding fluorescent dye.

Product Specific Literature References

Aureolic acid group of anti-tumour antibiotics: Y.U. Berlin, et al.; Nature 218, 193 (1968) Abstract
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure: M. Slavik & S.K. Carter; Adv. Pharmacol. Chemother. 12, 1 (1975) Abstract
Mithramycin blocks protein binding and function of the SV40 early promoter: R. Ray, et al.; J. Clin. Invest. 83, 2003 (1989) Abstract; Full Text
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem. 11, 2791 (2003) Abstract
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol. 164, 1663 (2004) Abstract; Full Text
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis 11, 113 (2006) Abstract

Further Categories Containing This Product:

DNA Fragmentation & Chromatin Condensation • Antibiotics - Immunomodulators • MDR Inhibitors

ALX-380-134

Revised 16-Sep-08

Pyrrolcarbonyltaloside
SYNONYMS	1-O-(Pyrrolylcarbonyl)-6-desoxy-α-L-talopyranoside
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-134-M001		1 mg	70.00 USD
ALX-380-134-M005		5 mg	280.00 USD

Product Specification

FORMULA:	C₁₁H₁₅NO₆
MW:	257.3
SOURCE/HOST:	Isolated from Kitasatospora sp. (Gö M1).
PURITY:	≥98%
APPEARANCE:	Brown solid.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Shows weak cytotoxic activity against different tumor cell lines. Has antiparasitic activity.

Product Specific Literature References

6-Deoxy-α-L-talopyranosids from Streptomyces sp.: J. Bitzer & A. Zeeck; Eur. J. Org. Chem. 2006, 3661

Further Categories Containing This Product:

ALX-385-002

Revised 11-Nov-08

(±)-Catechin
SYNONYMS	(±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-002-G001		1 g	80.00 USD

Product Specification

FORMULA:	C₁₅H₁₄O₆
MW:	290.3 (anhydrous basis)
CAS NUMBER:	7295-85-4
MERCK INDEX:	14: 1902
PURITY:	≥98% (HPLC)
APPEARANCE:	White to yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light. Keep under inert gas.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by IR.

Product Description

Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.

Product Specific Literature References

Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Free Radical Scavengers • Natural Products - Chemopreventive Agents • Flavanols • Natural Products - Antitumor Reagents

ALX-385-008

Revised 13-Mar-08

Apigenin
SYNONYMS	4',5,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-008-M010		10 mg	35.00 USD
ALX-385-008-M050		50 mg	105.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	520-36-5
MERCK INDEX:	14: 730
SOURCE/HOST:	Synthetic.
PURITY:	≥90% (HPLC)
APPEARANCE:	Light yellow to slightly brown powder.
SOLUBILITY:	Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.

Product Specific Literature References

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract

Further Categories Containing This Product:

MAPK Pathway Inhibitors • Hypoxia-inducible Factor [HIF] / Related Products • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Protein Kinase Inhibitors • VEGFs & VEGF-Rs Other Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Antitumor Agents (Anti-proliferative) • Natural Products - Antioxidants

ALX-385-009

Revised 03-Apr-08

Chrysin
SYNONYMS	5,7-Dihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-009-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₄
MW:	254.2
CAS NUMBER:	480-40-0
MERCK INDEX:	14: 2256
RTECS:	LK8329050
PURITY:	≥96%
APPEARANCE:	Yellow to tan solid.
SOLUBILITY:	Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review) Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007) Abstract

Further Categories Containing This Product:

Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Antitumor Reagents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants

ALX-385-010

Revised 08-Apr-08

(±)-Naringenin
SYNONYMS	(±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavanones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-010-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₁₅H₁₂O₅
MW:	272.3
CAS NUMBER:	67604-48-2
MERCK INDEX:	14: 6424
PURITY:	≥95%
APPEARANCE:	Light yellow to tan powder.
SOLUBILITY:	Soluble in 100% ethanol; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).