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ALX-210-135
Revised 21-May-08
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-135-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 100-115 (A
100
EPQKSPWCEARSLEH
115
) of human, mouse and rat ERβ (estrogen receptor β).
SPECIFICITY:
Recognizes human, mouse, rat, sheep and monkey ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION:
Gel Shift Assay (1-5µg/ml)
Immunocytochemistry (2-4µg/ml))
Immunohistochemistry ((frozen sections, paraffin sections (1-2µg/ml))
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-027
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Cloning of a novel receptor expressed in rat prostate and ovary:
G.G.J.H. Kuiper, et al.; PNAS
93
, 5925 (1996)
Abstract
ER beta: identification and characterization of a novel human estrogen receptor:
S. Mosselman, et al.; FEBS Lett.
392
, 49 (1996)
Abstract
Transcription and translation of estrogen receptor b in the male reproductive tract of estrogen receptor a-knock-out and wild-type mice:
C.S. Rosenfeld, et al.; Endocrinology
139
, 2982 (1998)
Abstract
Differing roles found for estrogen's two receptors:
E. Pennisi; Science
277
, 1439 (1997), (Research News)
Abstract
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta:
G.B. Tremblay, et al.; Mol. Endocrinol.
11
, 353 (1997)
Abstract
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta:
G.G.J.H. Kuiper, et al.; Endocrinology
138
, 863 (1997)
Abstract
Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain:
X. Li, et al.; Neuroendocrinology
66
, 63 (1997)
Abstract
A new actor in the estrogen receptor drama--enter ER-beta:
B.S. Katzenellenbogen & K.S. Korach; Endocrinology
138
, 861 (1997), (Editorial)
Abstract
Related Products
ALX-155-027
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-135
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-114
Revised 13-Dec-04
Polyclonal Antibody to FosB (mouse)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Fos & Jun Proteins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-114-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized. Purified IgG.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 102-117 (T
102
SYSTPGLSAYSTGGA
117
) of mouse FosB.
SPECIFICITY:
Recognizes mouse FosB and FosB2. Does not cross-react with human FosB.
APPLICATION:
Western Blot (10µg/ml (ECL))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-130
Revised 30-Jun-08
Polyclonal Antibody to c-Fos
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Fos & Jun Proteins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-130-C100
100 µg
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.1mg/ml
PURITY DETAIL:
Immunoaffinity purified IgG.
FORMULATION:
Liquid. In 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN:
Synthetic peptide corresponding to aa 4-17
(S
4
GFNADYEASSSRC
17
) of human c-Fos.
SPECIFICITY:
Recognizes human, mouse and rat c-Fos. Also recognizes v-Fos (viral oncogene Fos).
APPLICATION:
Immunocytochemistry
(1-5µg/ml)
Immunohistochemistry
(frozen sections (5-10µg/ml), paraffin sections (5-10µg/ml, pepsin or heat pre-treatment required))
Immunoprecipitation
(1-2µg per reaction)
Western Blot
(1-5µg/ml)
Suggested starting concentrations are provided. Antibodies should be titrated for optimal results in individual systems.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Specific Literature References
L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes
:
T.H. Murphy, et al.; Neuron
7
, 625 (1991)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-113
Revised 14-Jul-08
Polyclonal Antibody to c-Fos (mouse)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Fos & Jun Proteins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-113-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized. Purified IgG containing 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 4-17(S
4
GFNADYEASSSRC
17
) of mouse c-Fos.
SPECIFICITY:
Recognizes mouse c-Fos. Detects a band of ~60kDa by Western blot.
APPLICATION:
Western Blot (10µg/ml (ECL))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-436
Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
SYNONYMS
anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Forkhead Box [FOX] Proteins/Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-436-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY:
Recognizes both natural and recombinant mouse FOXP3. Detects a
band of ~46-49kDa by Western blot.
APPLICATION:
ELISA
(direct and indirect: 1:5’000-1:10’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3/Related Products
•
Polyclonal Antibodies
ALX-210-420
Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
SYNONYMS
anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Forkhead Box [FOX] Proteins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-420-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY:
Recognizes both natural and recombinant mouse FOXP3. Detects a band of ~46-49kDa by Western blot.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:10’000)
Western blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3/Related Products
•
Polyclonal Antibodies
ALX-210-109
Revised 18-May-06
Polyclonal Antibody to Fra-2 (human)
SYNONYMS
anti-Fos-related Antigen 2 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Fos & Jun Proteins/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-109-C200
200 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized. Purified IgG.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 288-302 (L
288
EQESPASPSESCSK
302
) of C-terminal human Fra-2 (fos-related antigen-2).
SPECIFICITY:
Recognizes human Fra-2.
APPLICATION:
Western Blot (10µg/ml (ECL))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-131
Revised 19-Nov-07
Polyclonal Antibody to Glucocorticoid Receptor
SYNONYMS
anti-GR PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-131-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 346-367 (D
346
QKPIFNVIPPIPVGSENWNRC
367
) of human GR (glucocorticoid receptor).
SPECIFICITY:
Recognizes all forms of human, mouse and rat GR. Detects a band of ~97kDa by Western blot. Does not interfere with receptor DNA binding.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry (paraffin sections)
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-157-015
.
Product Specific Literature References
Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors:
J.A. Cidlowski, et al.; Mol. Endocrinol.
4
, 1427 (1990)
Abstract
Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells:
J.E. Pawlowski, et al.; J. Biol. Chem.
277
, 20702 (2002)
Abstract
;
Full Text
Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells:
E.R. James, et al.; Invest. Ophthalmol. Vis. Sci.
44
, 5269 (2003)
Abstract
;
Full Text
Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A:
D.L. Drazen, et al.; Endocrinology
145
, 3404 (2004)
Abstract
Related Products
ALX-157-015
Blocking Peptide for PAb to Glucocorticoid Receptor (Prod. No.
ALX-210-131
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-153
Revised 07-May-07
Polyclonal Antibody to Glucocorticoid Receptor
SYNONYMS
anti-GR PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-153-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 245-259 (C
245
KPLILPDTKPKIKD
259
) of human GR (glucocorticoid receptor).
SPECIFICITY:
Recognizes human, mouse and rat GR. Detects a band of ~97kDa by Western blot. Does not interfere with receptor DNA binding.
APPLICATION:
Gel Shift Assays
Immunohistochemistry (frozen sections (1µg/ml))
Immunoprecipitation (5µg/m), Chromatin Immunoprecipitation
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-157-016
.
Product Specific Literature References
Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple forms in vitro and distinct localization of cytoplasmic and nuclear receptors:
J.A. Cidlowski, et al.; Mol. Endocrinol.
4
, 1427 (1990)
Abstract
Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structure:
C.L. Smith, et al.; J. Biol. Chem.
272
, 14227 (1997)
Abstract
;
Full Text
Related Products
ALX-157-016
Blocking Peptide for PAb to Glucocorticoid Receptor (Prod. No.
ALX-210-153
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-155
Revised 11-Nov-05
Polyclonal Antibody to Glucocorticoid Receptor
SYNONYMS
anti-GR PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-155-R200
200 µl
355.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 150-175 (A
150
PIEKEIPKIHSDVSSEQQHLKGQTG
175
) of human GR (glucocorticoid receptor).
SPECIFICITY:
Recognizes human and rat GR. Detects a band of ~97kDa by Western blot.
APPLICATION:
Gel Supershift Assay
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:100)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-277
Revised 14-Feb-07
Polyclonal Antibody to Glucocorticoid Receptor α
SYNONYMS
anti-GRα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-277-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 755-771 (C
755
EIITNQIPKYSN
GNIKK
771
) of human GRα (glucocorticoid receptor α
)
.
SPECIFICITY:
Recognizes human, mouse and rat GRα. Detects a ban
