ALEXIS Biochemicals: Pterostilbene

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ALX-270-125

Revised 25-Apr-08

Resveratrol
SYNONYMS	trans-3,4’,5-Trihydroxystilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-125-M050		50 mg	36.00 USD
ALX-270-125-M100		100 mg	50.00 USD
ALX-270-125-M250		250 mg	95.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₃
MW:	228.2
CAS NUMBER:	501-36-0
MERCK INDEX:	14: 8158
SOURCE/HOST:	Isolated from Polygonum cuspidatum.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	~65mg/ml soluble in DMSO, 100% ethanol or dimethyl formamide; slightly soluble in PBS, pH 7.2 (~100 µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. Antioxidant. Potent activator of human deacetylase SIRT1. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis.

Product Specific Literature References

Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996) Abstract
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) Abstract
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004) Abstract
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004) Abstract
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006) Abstract
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) Abstract

Related Products

ALX-385-034

Pterostilbene

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Stilbenoids • Sirtuins / Related Products • COX Inhibitors

ALX-270-202

Revised 07-Oct-08

Piceatannol
SYNONYMS	3,4,3',5'-Tetrahydroxy-trans-stilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-202-M001		1 mg	22.00 USD
ALX-270-202-M005		5 mg	62.00 USD
ALX-270-202-M010		10 mg	105.00 USD
ALX-270-202-M050		50 mg	375.00 USD

Product Specification

FORMULA:	C₁₄H₁₂O₄
MW:	244.3
CAS NUMBER:	10083-24-6
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Off-white to light pink crystalline solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide, 100% ethanol, methanol, acetone or ethyl acetate; slightly soluble in water (1mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Unstable in sodium hydroxide.
HANDLING:	Protect from light and oxygen.

Product Description

Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor. Activator of human deacetylase SIRT1.

Product Specific Literature References

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization: M. Cushman, et al.; J. Med. Chem. 34, 2579 (1991) Abstract
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol: J.M. Oliver, et al.; J. Biol. Chem. 269, 29697 (1994) Abstract; Full Text
The tyrosine phosphorylation of a p72syk-like protein in activated murine resident peritoneal macrophages: K.I. Abu-Lawi & B.M. Sultzer; Cell Mol. Biol. Res. 41, 49 (1995) Abstract
Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases: I. Fleming, et al.; Circul. Res. 76, 522 (1995) Abstract
Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase: J.M. Muller, et al.; Am. J. Physiol. 270, H1878 (1996) Abstract
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine: J.D. Peters, et al.; J. Biol. Chem. 271, 4755 (1996) Abstract; Full Text
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells: B. Cambien, et al.; J. Immunol. 163, 5079 (1999) Abstract; Full Text
FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells: C .Tkaczyk, et al.; Immunology 97, 333 (1999) Abstract
Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex: J. Zheng & V.D. Ramirez; BBRC 261, 499 (1999) Abstract
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells : D. Jeoung, et al.; Biotechnology Lett. 24, 463 (2002) Abstract; Full Text
Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro: C.J. Seow, et al.; Eur. J. Pharmacol. 443, 189 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003)

Further Categories Containing This Product:

Kinases in T Cell Signal Transduction / Related Products • B Cell Receptor [BCR] & Co-Receptors / Related Products • Tyrosine Kinase Inhibitors • Stilbenoids • Sirtuins / Related Products

ALX-350-114

Revised 03-Dec-07

Polydatin
SYNONYMS	Piceid Resveratrol-3β-mono-D-glucoside 3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-β-D-glucoside
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-114-M010		10 mg	90.00 USD

Product Specification

FORMULA:	C₂₀H₂₂O₈
MW:	390.4
CAS NUMBER:	65914-17-2
SOURCE/HOST:	Isolated from Polygonum cuspidatum.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in ethyl acetate, DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL. IRRITANT.

Product Description

Platelet aggregation inhibitor. Shows multiple effects on vascular smooth muscle cells, myocardial cells, endothelial cells and white blood cells after shock. May inhibit phospholipase A2. Inhibits the expression of various cell adhesion molecules.

Product Specific Literature References

Wine as a biological fluid: history, production, and role in disease prevention: G.J. Soleas, et al.; J. Clin. Lab. Anal. 11, 287 (1997) Abstract
Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes: Z.S. Huang, et al.; World J. Gastroenterol. 5, 41 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
The mechanism of Polydatin in shock treatment: K.S. Zhao, et al.; Clin. Hemorheol. Microcirc. 29, 211 (2003) Abstract
Effect of polydatin on phospholipase A2 in lung tissues in rats with endotoxic shock: S.Y. Shu, et al.; Chin. J. Traumatol. 7, 239 (2004) Abstract
Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury: Y. Cheng, et al.; Brain Res. 1110, 193 (2006) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products - Chemopreventive Agents • COX Inhibitors • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Stilbenoids

ALX-350-345

Revised 21-May-08

trans-3,4’,5-Trimethoxy-stilbene
SYNONYMS	Trimethoxy-resveratrol MR-3
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Angiogenesis Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-345-M025		25 mg	20.00 USD
ALX-350-345-M100		100 mg	60.00 USD

Product Specification

FORMULA:	C₁₇H₁₈O₃
MW:	270.3
CAS NUMBER:	22255-22-7
PURITY:	≥97% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (40mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description

Analog of resveratrol (Prod. No. ALX-270-125). Shows powerful anti-angiogenic activity.

Product Specific Literature References

Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene: M. Belleri, et al.; Mol. Pharmacol. 67, 1451 (2005) Abstract; Full Text
Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells: H. Matsuda, et al.; Bioorg. Med. Chem. 12, 4871 (2004) Abstract
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators: P. de Medina, et al.; J. Med. Chem. 48, 287 (2005) Abstract
Antitumor activity of 3,5,4’-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice: M.H. Pan, et al.; Mol. Carcinog. 47, 184 (2008) Abstract

Related Products

ALX-270-125

Resveratrol

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Stilbenoids

ALX-385-034

Revised 01-Dec-08

Pterostilbene
SYNONYMS	trans-3,5-Dimethoxy-4’-hydroxystilbene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-034-M025		25 mg	90.00 USD
ALX-385-034-M100		100 mg	270.00 USD
ALX-385-034-M500		500 mg	750.00 USD

Product Specification

FORMULA:	C₁₆H₁₆O₃
MW:	256.3
CAS NUMBER:	537-42-8
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (HPLC)
APPEARANCE:	Off-white to light brown powder.
SOLUBILITY:	Soluble in DMSO (20mg/ml) or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and oxygen.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by MS and ¹H-NMR.
MELTINGPOINT:	92.7-94.6°C

Product Description

Cell permeable natural methoxylated analog of resveratrol (Prod. No. ALX-270-125). Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Inhibits activator protein 1 (AP-1) and NF-κB activation. Moderately inhibits COX-1 and COX-2 (IC₅₀=19.8μM and 83.9μM).

Product Specific Literature References

Antihyperglycemic activity of phenolics from Pterocarpus marsupium: M Manickam, et al.; J. Nat. Prod. 60, 609 (1997) Abstract
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol: A.M. Rimando, et al.; J. Agric. Food Chem. 50, 3453 (2002) Abstract
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents: M. Roberti, et al.; J. Med. Chem. 46, 3546 (2003) Abstract
Antioxidant activity of hydroxystilbene derivatives in homogeneous solution: R. Amorati, et al.; J. Org. Chem. 69, 7101 (2004) Abstract
Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma: P. Ferrer, et al.; Neoplasia 7, 37 (2005) Abstract; Full Text
Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters: A.M. Rimando, et al.; J. Agric. Food Chem. 53, 3403 (2005) Abstract
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers: S. Hougee, et al.; Planta Med. 71, 387 (2005) Abstract
Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats: L. Pari & M.A. Satheesh; Life Sci. 79, 641 (2006) Abstract
Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities: R. Mikstacka, et al.; Xenobiotica 36, 269 (2006) Abstract
The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats: M. Amarnath Satheesh & L. Pari; J. Pharm. Pharmacol. 58, 1483 (2006) Abstract
Pharmacometrics of stilbenes: seguing towards the clinic: K.A. Roupe, et al.; Curr. Clin. Pharmacol. 1, 81 (2006) Abstract
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma: P. Ferrer, et al.; J. Biol. Chem. 282, 2880 (2007) Abstract; Full Text
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats: N. Suh, et al.; Clin. Cancer Res. 13, 350 (2007) Abstract; Full Text
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells: M.H. Pan, et al.; J. Agric. Food Chem. 55, 7777 (2007) Abstract
Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity: C.M. Remsberg, et al.; Phytother. Res. 22, 169 (2008) Abstract
Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol: Z. Pan, et al.; BMC Med. Genomics 1, 7 (2008) Abstract; Full Text
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis: M. Cichocki, et al.; Mol. Nutr. Food Res. 52, S62 (2008) Abstract
Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages: M.H. Pan, et al.; J. Agric. Food Chem. 56, 7502 (2008) Abstract
In vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs: B. Billack, et al.; Cell. Mol. Biol. Lett. 13, 553 (2008) Abstract