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ALX-350-120
Revised 01-Apr-08
Helenalin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-120-MC05
0.5 mg
240.00 USD
Product Specification
FORMULA:
C
15
H
18
O
4
MW:
262.3
CAS NUMBER:
6754-13-8
SOURCE/HOST:
Isolated from
Arnica chamissonis.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent anti-inflammatory and antineoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-X
L
or Bcl-2 are overexpressed. Also an inhibitor of NF-κB.
Product Specific Literature References
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB
:
G. Lyss, et al.; J. Biol. Chem.
378
, 951 (1997)
Abstract
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65:
G. Lyss, et al; J. Biol. Chem.
273
, 33508 (1998)
Abstract
Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A
:
W. Herz, et al.; JACS
85
, 19 (1963)
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
NF-kB Pathway Inhibitors
ALX-385-011
Revised 05-Apr-08
(±)-Hesperetin
SYNONYMS
(±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavanones
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-385-011-G001
1 g
21.00 USD
Product Specification
FORMULA:
C
16
H
14
O
6
MW:
302.3
CAS NUMBER:
520-33-2
MERCK INDEX:
14:
4670
PURITY:
≥95% (HPLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids:
C.A. Rice-Evans, et al.; Free Radical Biol. & Med.
20
, 933 (1996), (Review)
Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats:
H. K. Kim, et al.; Clin. Chim. Acta
327
, 129 (2003)
Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin:
J. Cho; Arch. Pharm. Res.
29
, 699 (2006)
Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin:
J. Y. Kim, et al.; Aging Cell
5
, 401 (2006)
Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21:
E.J. Choi; Nutr. Cancer
59
, 115 (2007)
Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products
•
Active Substances from Fruit and Vegetables
•
NF-kB Pathway Inhibitors
•
Natural Products - Antioxidants
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - NF-kB Pathway Inhibitors
ALX-340-057
Revised 10-Jul-08
12(S)-HpETE
SYNONYMS
12-(S)-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Eicosanoids Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-057-C025
25 µg
162.00 USD
ALX-340-057-C050
50 µg
308.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
71774-10-2
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes.
Product Description
Endogenous TRPV1 agonist (K
i
=0.35µM).
Product Specific Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances
:
S.W. Hwang, et al.; PNAS
97
, 6155 (2000)
Abstract
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
:
J. Shin, et al.; PNAS
99
, 10150 (2002)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fos & Jun Proteins / Related Products
•
Endovanilloids
ALX-340-058
Revised 10-Jul-08
15(S)-HpETE
SYNONYMS
15S-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Eicosanoids Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-058-C025
25 µg
41.00 USD
ALX-340-058-C050
50 µg
79.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
70981-96-3
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml).
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within 15 minutes.
Product Description
Endogenous TRPV1 agonist.
Product Specific Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances
:
S.W. Hwang, et al.; PNAS
97
, 6155 (2000)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fos & Jun Proteins / Related Products
•
Endovanilloids
ALX-201-024
Revised 24-Feb-05
HSF1 (human) (recombinant)
SYNONYMS
Heat Shock Factor 1 (human) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Stress & Heat Shock Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-024-C150
150 µg
343.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
FORMULATION:
Liquid. Sonicated
E. coli
extract at a total protein concentration of 6mg/ml in 25mM HEPES, pH 7.9, 12.5mM MgCl, 0.1mM EDTA, 10% glycerol, 1mM DTT, 0.1% NP-40 and 300mM KCl and protease inhibitors.
APPLICATION:
Positive control in gel shift assays (25 tests) or Western blot (50 tests) with PAb to HSF1 (Prod. No.
ALX-210-129
). DNase I footprinting and
in vitro
transcription assays.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-20°C
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q00613:
HSF 1 (human)
Further Categories Containing This Product:
Transcription Factors Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-370-012
Revised 09-Oct-07
20-Hydroxyecdysone
SYNONYMS
β-Ecdysone
2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one
Ecdysterone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Ecdysteroids
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-370-012-M005
5 mg
55.00 USD
ALX-370-012-M010
10 mg
90.00 USD
ALX-370-012-M050
50 mg
350.00 USD
Product Specification
FORMULA:
C
27
H
44
O
7
MW:
480.6
CAS NUMBER:
5289-74-7
MERCK INDEX:
14:
3491
PURITY:
≥95%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of
Drosophila melanogaster.
Product Specific Literature References
H. Hampshire and D.H.S. Horn; Chem. Commun. 37 (1966)
M.N. Galbraith and D.H.S. Horn; Chem. Commun. 905 (1966)
H. Rimpler and G. Schulz; THL
22
, 2033 (1967)
L. Canonica, et al.; Phytochemistry
14
, 525 (1975)
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death:
C. Cao, et al.; J. Cell Biol.
176
, 843 (2007)
Abstract
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins / Related Products
•
Non-apoptotic Cell Death / Necrosis
ALX-350-289
Revised 18-Nov-08
10Z-Hymenialdisine
SYNONYMS
4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-
c
]azepin-8-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-289-C500
500 µg
190.00 USD
ALX-350-289-M001
1 mg
340.00 USD
Product Specification
FORMULA:
C
11
H
10
BrN
5
O
2
MW:
324.1
CAS NUMBER:
82005-12-7
SOURCE/HOST:
Isolated from sponge
Axinella carteri
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow needles.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H- NMR and MS.
Product Description
Originally isolated from the sponges
Axinella verrucosa
and
Acantella aurantiaca
. Potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC
50
=6nM). Blocks the
in vivo
phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase (IC
50
=6µM), cyclin-dependent kinases CDK1/cyclin B (IC
50
=22nM), CDK2/cyclin A (IC
50
=70nM), CDK2/cyclin E (IC
50
=40nM), CDK4/cyclin D1 (IC
50
=600nM), CDK5/p25 (IC
50
=28nM), GSK-3β
(IC
50
=10nM), and
casein kinase 1 (CK1) (IC
50
=35nM). Inhibitor of NF-κB activation and of various pro-inflammatory cytokines such as IL-1, IL-2 (IC
50
=2.4µM), IL-6, IL-8, TNF-α (IC
50
=1.4µM) and nitric oxide (NO) (IC
50
=0.8µM) in a variety of cell lines.
Product Specific Literature References
Isolation and x-ray crystal structure of a novel bromo-compound from two marine sponges
:
G. Cimino, et al.; Tetrahedron Lett.
23
, 767 (1982)
Bioactive alkaloids from the tropical marine sponge Axinella carteri
:
A. Supriyono, et al.; Z. Naturforsch. [C]
50
, 669 (1995)
Abstract
The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB
:
J.J. Breton & M.C. Chabot-Fletcher; J. Pharmacol. Exp. Ther.
282
, 459 (1997)
Abstract
;
Full Text
Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine
:
A. Roshak, et al.; J. Pharmacol. Exp. Ther.
283
, 955 (1997)
Abstract
;
Full Text
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine
:
A.M. Badger, et al.; J. Pharmacol. Exp. Ther.
290
, 587 (1999)
Abstract
;
Full Text
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent
:
L. Meijer, et al.; Chem. Biol.
7
, 51 (2000)
Abstract
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine
:
D. Curman, et al.; J. Biol. Chem.
276
, 17914 (2001)
Abstract
;
Full Text
An investigation of cell proliferation and soluble mediators induced by interleukin 1beta in human synovial fibroblasts: comparative response in osteoarthritis and rheumatoid arthritis
:
H. Inoue, et al.; Inflamm. Res.
50
, 65 (2001)
Abstract
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
:
D. Tasdemir, et al.; J. Med. Chem.
45
, 529 (2002)
Abstract
Inhibition of cytokine production by hymenialdisine derivatives
:
V. Sharma, et al.; J. Med. Chem.
47
, 3700 (2004)
Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
MAPK Pathway Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
NF-kB Pathway Inhibitors
•
Natural Products for Cell Cycle Research
•
Alkaloids
•
Natural Products - Nitric Oxide Pathway Modulators
•
DNA Damage Checkpoint Other Products
•
GSK-3 Inhibitors
•
Marine Natural Products
ALX-522-143
Revised 24-Nov-08
IL-1RAcP (human):Fc (human) (recombinant)
SYNONYMS
Interleukin-1 Receptor Accessory Protein (human):Fc (human) (recombinant)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Interleukin-1 [IL-1] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-143-C050
50 µg
390.00 USD
Product Specification
MW:
~80kDa
SOURCE/HOST:
Produced in HEK 293 cells. The extracellular domain of human IL-1RAcP (aa 21-356) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Lonza).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9NPH3:
IL-1RAcP (human)
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
NF-kB Pathway Other Products
ALX-420-039
Revised 14-Aug-08
Imiquimod
SYNONYMS
1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
R-837
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Agonists Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-420-039-M100
100 mg
55.00 USD
ALX-420-039-M250
250 mg
120.00 USD
Product Specification
FORMULA:
C
14
H
16
N
4
MW:
240.3
CAS NUMBER:
99011-02-6
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
Product Description
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Specific Literature References
Imiquimod applied topically: a novel immune response modifier and new class of drug:
R.L. Miller, et al.; Int. J. Immunopharmacol.
21
, 1 (1999)
Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway:
H. Hemmi, et al.; Nat. Immunol.
3
, 196 (2002)
Abstract
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases:
C. Hesling, et al.; Br. J. Dermatol.
150
, 761 (2004)
Abstract
Imiquimod as an antiangiogenic agent:
V.W. Li, et al.; J. Drugs Dermatol.
4
, 708 (2005)
Abstract
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis:
S. Majewski, et al.; Int. J. Dermatol.
44
, 14 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.
Related Products:
- ddWater (endotoxin-free) (Prod. No.
ALX-505-008
)
- PBS (endotoxin-free) (Prod. No.
ALX-505-007
)
Related Products
ALX-505-007
PBS (endotoxin-free)
ALX-505-008
ddWater (endotoxin-free)
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers)
•
Angiogenesis Modulators Other Products
•
Inflammasome
•
MMPs Other Products
ALX-350-245
Revised 07-Apr-08
Lactacystin (native)
