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DNA Regulation / Transcription
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ALX-350-371 Revised 10-Mar-08
Harmine
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SYNONYMS Leucoharmine
Banisterine
Telepathine
Yageine
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-371-M250   250 mg 22.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O
MW: 212.3
CAS NUMBER: 442-51-3
MERCK INDEX: 14: 4616
RTECS: UV0175000
SOURCE/HOST: Originally isolated from Peganum harmala.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Alkaloid of the β-carboline family. Regulates PPARγ expression. Inhibits the Wnt signalling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits monoamine oxidase inhibitor A (MAO-A), but has no effect on MAO-B.
Product Specific Literature References
The chemotherapy of derivatives of harmine and harmaline. I: C.E. Coulthard, et al.; Biochee. J. 27, 727 (1933) Abstract; Full Text
The chemotherapy of derivatives of harmine and harmaline. II: C.E. Coulthard; Biochem. J. 28, 264 (1934) Abstract; Full Text
Interrelationships between amphetamine and harmala alkaloids: H. Schmitt; Nature 203, 877 (1964) Abstract
Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline: J. Gerardy; Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 793 (1994) Abstract
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism: A.F. Abdel-Fattah, et al.; Pharmacol. Biochem. Behav. 52, 421 (1995) Abstract
The mode of action of thiazolidinediones: H. Hauner; Diabet. Metab. Res. Rev. 18, S10 (2002) Abstract
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis: Q. Chen, et al.; Int. J. Cancer 114, 675 (2005) Abstract
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression: H. Waki, et al.; Cell Metab. 5, 357 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • TNF-alpha & TNF Receptors Other Products • Wnt Signalling Pathway Other Products • NOS Regulation • Antidiabetic Agents / Related Products • Interleukin-1 [IL-1] & Receptors / Related Products • Alkaloids
 
 
ALX-350-333 Revised 05-Apr-08
Harpagoside
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-333-M005   5 mg 90.00 USD Add To Cart
ALX-350-333-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C24H30O11
MW: 494.5
CAS NUMBER: 19210-12-9
SOURCE/HOST: Isolated from Scrophularia ningpoensis Hemsl (Figwort).
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Anti-inflammatory and anti-diabetic compound. Suppresses LPS-induced inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2) expression through inhibition of NF-κB activation.
Product Specific Literature References
Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens: L. D. Garcia, et al.; Farmaco. 51, 443 (1996) Abstract
Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets: S. Chrubasik, et al.; Phytomedicine 6, 469 (2000) Abstract
Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity: B. Ahmed, et al.; Biol. Pharm. Bull. 26, 462 (2003) Abstract; Full Text
Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects: M. Kaszkin, et al.; Phytomedicine 11, 585 (2004) Abstract
High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens: M. Gunther, et al.; Phytochem. Anal. 17, 1 (2006) Abstract
Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation: T.H. Huang, et al.; J. Ethnopharmacol. 104, 149 (2006) Abstract
Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study: P. Li, et al.; Anal. Bioanal. Chem. 389, 2259 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • NF-kB Pathway Inhibitors • COX Other Products • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-850-326 Revised 07-Jan-08
HAT Activity Assay Kit
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histone Acetyl- & Methyl-Transferases / Related Products
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ALX-850-326-KI01   1 Kit 413.00 USD Add To Cart
Product Specification
QUANTITY: ~100 tests.
KIT/SET CONTAINS: 2x HAT Assay Buffer
HAT Substrate I
HAT Substrate II
NADH Generating Enzyme
NE (Nuclear Extract 4 mg/ml)
HAT Reconstitution Buffer
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
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Product Description
Histone acetyltransferases (HATs) have been implicated to play a crucial role in various cellular functions, such as gene transcription, differentiation, and proliferation. HAT Activity Colorimetric Assay Kit offers a convenient, nonradioactive system for a rapid and sensitive detection of HAT activity in mammalian samples. The kit utilizes active recombinant HAT as a positive control and acetyl-CoA as a cofactor. Acetylation of peptide substrate by active HAT releases the free form of CoA which then serves as an essential coenzyme for producing NADH. NADH can easily be detected spectrophotometrically upon reacting with a soluble tetrazolium dye. The detection can be continuous and suitable for kinetic studies. The kit provides a simple, straightforward protocol for a complete assay.
Product Specific Literature References
Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells: P.A. Ruiz, et al.; J. Nutr. 137, 1208 (2007) Abstract
General Information
MANUFACTURER Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
 
 
ALX-630-102 Revised 05-Apr-08
HC Toxin
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SYNONYMS Cyclo-(D-Pro-L-Ala-D-Ala-L-2-amino-8-oxo-9,10-epoxydecanoic acid)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-630-102-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C21H32N4O6
MW: 436.5
CAS NUMBER: 83209-65-8
SOURCE/HOST: Isolated from Helminthosporium carbonium.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable as supplied for up to 1 year. Stock solutions are stable for up to 3 months when stored at -20°C
HAZARD: TOXIC.

Product Description
Potent, cell permeable, non-competitive and reversible inhibitor of histone deacetylase (HDAC) (IC50=30nM). Does not inhibit histone acetyltransferases. Induces expression of γ-globulin in erythroid cells. Shows anti-mitogenic activities. Induces cell cycle arrest and apoptosis in tumor cells.
Product Specific Literature References
The structure and conformation of HC-toxin: M. Kawai, et al.; Biochem. Biophys. Res. Commun. 111, 398 (1983) Abstract
Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum: G. Brosch, et al.; Plant Cell 7, 1941 (1995) Abstract
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells: K.N. Min, et al.; Arch. Pharm. Res. 27, 554 (2004) Abstract
Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells: K.E. Joung, et al.; Arch. Pharm. Res. 27, 640 (2004) Abstract
Further Categories Containing This Product:
HDAC Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products for Cell Cycle Research
 
 
ALX-350-120 Revised 01-Apr-08
Helenalin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-120-MC05   0.5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C15H18O4
MW: 262.3
CAS NUMBER: 6754-13-8
SOURCE/HOST: Isolated from Arnica chamissonis.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (10mg/ml) or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent anti-inflammatory and antineoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-XLor Bcl-2 are overexpressed. Also an inhibitor of NF-κB.
Product Specific Literature References
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB: G. Lyss, et al.; J. Biol. Chem. 378, 951 (1997) Abstract
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65: G. Lyss, et al; J. Biol. Chem. 273, 33508 (1998) Abstract
Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A: W. Herz, et al.; JACS 85, 19 (1963)
Further Categories Containing This Product:
Bcl-2 Family Modulators • Antitumor Agents (Apoptosis Inducers) • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-350-303 Revised 12-Feb-07
Heraclenin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-303-M002   2 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C16H14O5
MW: 286.3
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in methanol or water. Almonst insoluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
The furanocoumarins heraclenin (Prod. No. ALX-350-303) and imperatorin (Prod. No. ALX-350-302) inhibit T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Both compounds also induce apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.
Product Specific Literature References
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin: G. Appendino, et al.; J. Nat. Prod. 67, 532 (2004) Abstract
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT: N. Marquez, et al.; Planta Med. 70, 1016 (2004) Abstract
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway: R. Sancho, et al.; J. Biol. Chem. 279, 37349 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
DNA Fragmentation & Chromatin Condensation
 
 
ALX-385-011 Revised 05-Apr-08
(±)-Hesperetin
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SYNONYMS (±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-011-G001   1 g 21.00 USD Add To Cart
Product Specification
FORMULA: C16H14O6
MW: 302.3
CAS NUMBER: 520-33-2
MERCK INDEX: 14: 4670
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats: H. K. Kim, et al.; Clin. Chim. Acta 327, 129 (2003) Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin: J. Cho; Arch. Pharm. Res. 29, 699 (2006) Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin: J. Y. Kim, et al.; Aging Cell 5, 401 (2006) Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21: E.J. Choi; Nutr. Cancer 59, 115 (2007) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-340-037 Revised 08-Jul-08
8(S)-HETE
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SYNONYMS 8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
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ALX-340-037-C025   25 µg 165.00 USD Add To Cart
Product Specification
FORMULA: C20H32O3
MW: 320.5
CAS NUMBER: 98462-03-4
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING: Protect from light and oxygen.

Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin: M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta 1081, 347 (1991) Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites: H.H. Lo, et al.; Lipids 29, 547 (1994) Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu, et al.; J. Biol. Chem. 270, 23975 (1995) Abstract; Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans: Y. Guan, et al.; Am. J. Physiol. 273, F1013 (1997) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists • PKC Activators
 
 
ALX-350-138 Revised 05-Dec-06
Hexaprenylhydroquinone
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SYNONYMS HPH
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral / anti-HIV Agents
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ALX-350-138-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C36H54O2
MW: 518.8
CAS NUMBER: 119980-00-6
SOURCE/HOST: Isolated from Sarcotragus sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Specific Literature References
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod. 57, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod. 57, 1711 (1994) Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J. 324, 721 (1997) Abstract; Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res. 18, 1 (2004) Abstract
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol. 285, 281 (1995) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Natural Products - DNA Replication Inhibitors • Marine Natural Products • HIV / AIDS / Related Products
 
 
ALX-202-057 Revised 08-Dec-04
Histone (calf thymus)
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PRODUCT LINE DNA Regulation / Transcription