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ALX-270-168
Revised 18-May-06
Tyrphostin AG 490
SYNONYMS
Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-168-M005
5 mg
45.00 USD
ALX-270-168-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
17
H
14
N
2
O
3
MW:
294.3
CAS NUMBER:
133550-30-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO and acetone; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosine kinase. Does not significantly inhibit other kinases, such as Lck, Lyn, Btk, Syk or Src. Blocks IL-7 induced JAK kinase activity in T cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. Valuable tool for studying the cellular role of JAK kinases in signal transduction.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]:
A. Levitzki; Biochem. Pharmacol.
40
, 913 (1990)
Abstract
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity:
H. Dadi, et al.; Blood
84
, 1579 (1994)
Abstract
;
Full Text
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3’ kinase
:
N. Sharfe, et al.; Blood
86
, 2077 (1995)
Abstract
;
Full Text
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor:
N. Meydan, et al.; Nature
379
, 645 (1996)
Abstract
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells:
R.A. Kirken, et al.; J. Leukoc. Biol.
65
, 891 (1999)
Abstract
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response:
L.H. Wang, et al.; J. Immunol.
162
, 3897 (1999)
Abstract
JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells:
J. De Vos, et al.; Br. J. Haematol.
109
, 823 (2000)
Abstract
Further Categories Containing This Product:
Janus Kinases [JAKs] / Related Products
•
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-270-143
Revised 20-Feb-08
Tyrphostin AG 494
SYNONYMS
Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-143-M005
5 mg
25.00 USD
ALX-270-143-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
12
N
2
O
3
MW:
280.3
CAS NUMBER:
133550-35-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Tyrphostin AG 494 blocks Cdk2 activation:
N. Osherov & A. Levitzki; FEBS Lett.
410
, 187 (1997)
Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase:
N. Kleinberger-Doron, et al.; Exp. Cell Res.
241
, 340 (1998)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-147
Revised 03-Dec-04
Tyrphostin AG 528
SYNONYMS
Tyrphostin B66
N-(3',4'-Dihydroxybenzylidenecyanoacetyl)indoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-147-M005
5 mg
30.00 USD
ALX-270-147-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
18
H
14
N
2
O
3
MW:
306.3
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-059
Revised 11-Dec-04
Tyrphostin AG 537
SYNONYMS
Bis-Tyrphostin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-059-M005
5 mg
65.00 USD
ALX-270-059-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
23
H
20
N
4
O
6
MW:
448.4
PURITY:
≥98%
APPEARANCE:
Solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Description
Competitively inhibits EGF receptor kinase autophosphorylation.
Product Specific Literature References
Tyrphostins as molecular tools and potential antiproliferative drugs:
A. Levitzki & C. Gilon; TIPS
12
, 171 (1991), (Review)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
ALX-270-142
Revised 11-Dec-04
Tyrphostin AG 555
SYNONYMS
Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-142-M005
5 mg
25.00 USD
ALX-270-142-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
MW:
322.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-146
Revised 11-Dec-04
Tyrphostin AG 556
SYNONYMS
Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-146-M005
5 mg
25.00 USD
ALX-270-146-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
20
N
2
O
3
MW:
336.4
CAS NUMBER:
133550-41-1
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-136
Revised 05-Dec-04
Tyrphostin AG 658
SYNONYMS
Tyrphostin C6
4-Hydroxy-3-methoxy-5-(phenylthiomethyl)benzylidenecyano-acetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-136-M001
1 mg
30.00 USD
ALX-270-136-M005
5 mg
95.00 USD
ALX-270-136-M025
25 mg
310.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
S
MW:
340.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in dark. Protect from light.
ALX-270-145
Revised 11-Dec-04
Tyrphostin AG 698
SYNONYMS
Tyrphostin B52
N-(2-Phenylethyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-145-M005
5 mg
30.00 USD
ALX-270-145-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-165
Revised 11-Dec-04
Tyrphostin AG 808
SYNONYMS
2-Cyano-3-(3',4'-dihydroxyphenyl)-1-(3''-indolyl)-3-oxo-1-propene
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-165-M005
5 mg
45.00 USD
ALX-270-165-M025
25 mg
130.00 USD
Product Specification
FORMULA:
C
18
H
12
N
2
O
3
MW:
304.3
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in dark. Protect from light.
ALX-270-137
Revised 03-Apr-06
Tyrphostin AG 825
SYNONYMS
Tyrphostin C15
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzyl-idenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-137-M001
1 mg
35.00 USD
ALX-270-137-M005
5 mg
100.00 USD
Product Specification
FORMULA:
C
19
H
15
N
3
O
3
S
2
MW:
397.5
CAS NUMBER:
149092-50-2
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
ALX-270-144
Revised 07-Dec-04
Tyrphostin AG 835
SYNONYMS
Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantit
