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Signal Transduction
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ALX-260-082 Revised 24-Feb-05
Ac-WEHD-pNA
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SYNONYMS Caspase-1 Substrate (Chromogenic)
Caspase-5 Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-082-M001   1 mg 32.00 USD Add To Cart
ALX-260-082-M005   5 mg 93.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Trp-Glu-His-Asp-pNA (pNA=p-Nitroaniline)
FORMULA: C34H37N9O11
MW: 747.7
PEPTIDE CONTENT: 70-90%
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO. Dilute with buffer, pH 7.5. Also soluble in buffer, pH 7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Chromogenic substrate for caspase-1 and -5. Also a substrate for caspase-4.
Product Specific Literature References
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION λmax of pNA is 400nm.
 
 
ALX-260-108 Revised 03-Jun-05
Ac-YVAD-AFC
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SYNONYMS Caspase-1 Substrate (Fluorogenic)
Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-108-M005   5 mg 147.00 USD Add To Cart
ALX-260-108-M010   10 mg 275.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA: C33H36F3N5O10
MW: 719.7
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1 and -4.
Product Specific Literature References
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP: M. Marcelli, et al.; Cancer Res. 58, 76 (1998) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
 
 
ALX-260-024 Revised 17-Jan-06
Ac-YVAD-AMC
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SYNONYMS Caspase-1 Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-024-M001   1 mg 37.00 USD Add To Cart
ALX-260-024-M005   5 mg 98.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA: C33H39N5O10
MW: 665.7
PEPTIDE CONTENT: 75-95%
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO. Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1.
Product Specific Literature References
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Interleukin-1 β converting enzyme: N.A. Thornberry; Meth. Enzymol. 244, 615 (1994) Abstract
Crystal structure of the cysteine protease interleukin-1 β-converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
 
 
ALX-260-027 Revised 03-May-07
Ac-YVAD-CHO
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SYNONYMS Caspase-1 Inhibitor (Aldehyde)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-027-M001   1 mg 42.00 USD Add To Cart
ALX-260-027-M005   5 mg 163.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-CHO
FORMULA: C23H32N4O8
MW: 492.5
PEPTIDE CONTENT: 70-90%
PURITY: ≥96% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized. TFA salt.
SOLUBILITY: Soluble in DMSO or water.
RECONSTITUTION: Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Keep cool and dry. Keep under inert gas.
Product Description
Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.
Product Specific Literature References
K.T. Chapman; Bioorg. Med. Chem. Lett. 2, 613 (1992)
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme: S.M. Molineaux, et al.; PNAS 90, 1809 (1993) Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract
Structure and mechanism of interleukin-1 β converting enzyme: K.P. Wilson, et al.; Nature 370, 270 (1994) Abstract
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis: M. Los, et al.; Nature 375, 81 (1995) Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995) Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996) Abstract
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem. 271, 3505 (1996) Abstract; Full Text
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998) Abstract; Full Text
 
 
ALX-260-028 Revised 27-Mar-08
Ac-YVAD-CMK
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SYNONYMS Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-028-M001   1 mg 55.00 USD Add To Cart
ALX-260-028-M005   5 mg 220.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-chloromethylketone
FORMULA: C24H33N4O8Cl
MW: 541.0
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.
Product Specific Literature References
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994) Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract
Involvement of an ICE-like protease in Fas-mediated apoptosis: M. Enari, et al.; Nature 375, 78 (1995)
Involvement of interleukin-1 beta-converting enzyme in apoptosis of bFGF-deprived murine aortic endothelial cells: S. Kondo, et al.; FASEB J. 10, 1192 (1996) Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995) Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996) Abstract
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis: N. Rouquet, et al.; Curr. Biol. 6, 1192 (1996) Abstract
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses: G. Mathiak, et al.; Br. J. Pharmacol. 131, 383 (2000) Abstract
 
 
ALX-260-016 Revised 10-Feb-05
Ac-YVAD-2,6-dimethylbenzoyloxymethylketone
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SYNONYMS Caspase-1 Inhibitor
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-016-M001   1 mg 75.00 USD Add To Cart
ALX-260-016-M005   5 mg 290.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-2,6-dimethylbenzoyloxymethylketone
FORMULA: C33H42N4O10
MW: 654.7
PEPTIDE CONTENT: 78-99%
PURITY: ≥95% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING: Keep cool and dry.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4.
Product Specific Literature References
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry 33, 3934 (1994) Abstract
 
 
ALX-260-026 Revised 24-Feb-05
Ac-YVAD-pNA
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SYNONYMS Caspase-1 Substrate (Chromogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-026-M001   1 mg 32.00 USD Add To Cart
ALX-260-026-M005   5 mg 68.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Tyr-Val-Ala-Asp-pNA (pNA=p-Nitroaniline)
FORMULA: C29H36N6O10
MW: 628.6
PEPTIDE CONTENT: 75-95%
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO. Dilute with buffer pH 7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Chromogenic substrate for caspase-1.
Product Specific Literature References
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Peptidic p-nitroanilide substrates of interleukin-1 β-converting enzyme: L.A. Reiter; Int. J. Pept. Protein Res. 43, 87 (1994) Abstract
Interleukin-1 β converting enzyme: N.A. Thornberry; Meth. Enzymol. 244, 615 (1994) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION λmax of pNA is 400nm.
 
 
AG-AE0631 Revised 11-Jan-08
ACE2 (human) ELISA Kit
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SYNONYMS Angiotensin-converting Enzyme 2 (human) ELISA Kit
SARS Receptor (human) ELISA Kit
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-AE0631EK-KI01   96 wells 590.00 USD Add To Cart
AG-AE0631TP-KI01 Twin Plex 2x96 wells 890.00 USD Add To Cart
AG-AE0631PP-KI01 Penta Plex 5x96 wells 1'870.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 293pg/ml (range 0 to 50ng/ml)
APPLICATION: For the quantitative determination of ACE2 in human urine samples or cell culture supernatants.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
SARS Coronavirus / Related Products • ELISA & EIA Kits
 
 
ALX-201-330 Revised 24-Jul-06
ACE2 (human):Fc (human) (recombinant)
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SYNONYMS Angiotensin-converting Enzyme 2 (human):Fc (human) (recombinant)
SARS Receptor (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
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ALX-201-330-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide sequence and the extracellular domain of human ACE2 (angiotensin-converting enzyme 2) (aa 1-740) are fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
BIOLOGICAL ACTIVITY: Converts angiotensin I to angiotensin-(1-9).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9NRA7: Angiotensin converting enzyme-like protein (human)
MANUFACTURER Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
SARS Coronavirus / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-356 Revised 18-Mar-08
ACE2, Soluble (human) (recombinant)
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SYNONYMS Angiotensin-converting Enzyme 2, Soluble (human) (recombinant)
SARS Receptor, Soluble (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-356-C010   10 µg 295.00 USD Add To Cart
ALX-201-356-C050   50 µg 795.00 USD Add To Cart
Product Specification
EC: 3.4.17.-
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide sequence and the extracellular domain of human ACE2 (angiotensin-converting enzyme 2) (aa 1-740) are fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY: Converts angiotensin I to angiotensin-(1-9).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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