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Thyroid Hormones & Thyroid Hormone Receptors / Related Products
You are here: Product Lines > DNA Regulation / Transcription > Nuclear Receptors / Related Products > Thyroid Hormones & Thyroid Hormone Receptors / Related Products
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ALX-BC-6010-S Revised 23-Jun-08
Monoclonal Antibody to Thyroid Peroxidase (human) (TPO 47)
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SYNONYMS anti-TPO (human) MAb (TPO 47)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-BC-6010-S-L001   1 ml 295.00 USD Add To Cart
ALX-BC-6010-S-L005   5 ml 990.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TPO 47
ISOTYPE: Mouse IgG1
FORMULATION: Sterile supernatant. 0.6 - 0.9g/ml. Contains 0.1% sodium azide.
IMMUNOGEN: Human TPO (thyroid peroxidase).
SPECIFICITY: Recognizes a linear epitope (aa 713-721) on human TPO protein. Assists immunocytological diagnosis of malignancy on fine needle aspirates (FNA) of thyroid nodules. Strongly stains human TPO in normal thyroid tissues but does not recognize tumoral human TPO.
APPLICATION: Immunohistochemistry (paraffin sections), Western Blot (dilution 1:2-1:10).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
[1] Relationship between immunological structure and biochemical properties of human thyroid peroxidase: J. Ruf, et al.; Endocrinology 125, 1211 (1989) Abstract
[2] Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues: C. De Micco, et al.; Cancer 67, 3036 (1991) Abstract
[3] Current Evaluation of Thyroid Nodules: H. Gharib; Trends Endocrinol. Metab. 5, 365 (1994)
[4] Malignancy markers in the cytodiagnosis of thyroid nodules. Thyroid peroxidase: C. De Micco, et al.; Ann. Pathol. 14, 378 (1994) Abstract
[5] Thyroperoxidase immunodetection for the diagnosis of malignancy on fine- needle aspiration of thyroid nodules: J.-F. Henry, et al.; World J. Surg. 18, 529 (1994) Abstract
[6] Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy: C. De Micco, et al.; Eur. J. Endocrinol. 131, 474 (1994) Abstract
[7] Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47: C. De Micco, et al.; Surgery 116, 1031 (1994) Abstract
[8] A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase: V. Estienne, et al.; J. Biol. Chem. 273, 8056 (1998) Abstract; Full Text
[9] Molecular model, calcium sensitivity, and disease specificity of a conformational thyroperoxidase B-cell epitope: V. Estienne, et al.; J. Biol. Chem. 274, 35313 (1999) Abstract; Full Text
[10] Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures: N. Caraccio, et al.; J. Clin. Endocrinol. Metab. 90, 1156 (2005) Abstract; Full Text
[11] Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma: M. Landriscina, et al.; J. Clin. Endocrinol. Metab. 90, 5663 (2005) Abstract; Full Text
BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer: C. Romei, et al.; Endocr. Relat. Cancer. 2, 511 (2008) Abstract
General Information
MANUFACTURER Manufactured by BioCytex.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-163 Revised 14-Nov-05
Polyclonal Antibody to Thyroid Hormone Receptor α-1
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SYNONYMS anti-TRα-1 PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-163-R100   100 µl 524.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 403-410 (E403VFEDQEV410) of human TRα-1 (thyroid hormone receptor α-1).
SPECIFICITY: Recognizes human and chicken TRα-1. Detects a band of ~48kDa by Western blot. Does not cross-react with TRα-2 or TRβ-1.
APPLICATION: Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-165 Revised 21-Dec-06
Polyclonal Antibody to Thyroid Hormone Receptor β-1
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SYNONYMS anti-TRβ-1 PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-165-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 67-86 (I67FHLDHDDVNDQSVSSAQTF86) of human TRβ-1 (thyroid hormone receptor β-1).
SPECIFICITY: Recognizes human and rat TRβ-1. Detects a band of ~55kDa by Western blot. Does not cross-react with TRα-1 or TRα-2.
APPLICATION: Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 

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