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Guanosine Derivatives Other Products
You are here: Product Lines > DNA Regulation / Transcription > DNA Fragmentation, Damage & Repair > Guanosine Derivatives Other Products
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ALX-480-081 Revised 31-May-07
Guanosine 5'-O-(2-thiodiphosphate) . trilithium salt
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SYNONYMS GDP-β-S . 3Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-081-M001   1 mg 25.00 USD Add To Cart
ALX-480-081-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O10P2S . 3Li
MW: 456.2 . 20.8
CAS NUMBER: 97952-36-8
PURITY: ≥85% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. Unstable at room temperature.

Product Description
Cell impermeable, non-hydrolyzable analog of guanosine 5'-O-diphosphate (GDP) that competitively inhibits G-protein activation by GTP and GTP analogs. Use at concentrations similar to GTP-γ-S (Prod. No. ALX-480-056) (50 µM).
Product Specific Literature References
A.G. Gilman, et al.; Annu. Rev. Biochem. 56, 615 (1987) Abstract
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2: R.M. Burch & J. Axelrod; PNAS 84, 6374 (1987) Abstract
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes: S.T. Silk, et al.; J. Biol. Chem. 264, 21466 (1989) Abstract; Full Text
 
 
ALX-480-056 Revised 26-Mar-08
Guanosine 5'-O-(3-thiotriphosphate) . tetralithium salt
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SYNONYMS GTP-γ-S . 4Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-056-M001   1 mg 45.00 USD Add To Cart
ALX-480-056-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O13P3S . 4Li
MW: 535.2 . 27.8
CAS NUMBER: 94825-44-2
PURITY: ≥88%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Analog of guanosine 5'-O-triphosphate (GTP) with resistance to enzymatic hydrolysis. Stimulates inositol trisphosphate formation in membranes.
Product Specific Literature References
G proteins: transducers of receptor-generated signals: A.G. Gilman; Ann. Rev. Biochem. 56, 615 (1987) Abstract
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C: S. Orellana, et al.; J. Biol. Chem. 262, 1638 (1987) Abstract; Full Text
A functional role for GTP-binding proteins in synaptic vesicle cycling: S.D. Hess, et al.; Science 259, 1169 (1993) Abstract
 
 
ALX-480-057 Revised 16-Dec-04
Guanosine 5'-triphosphate . dilithium salt
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SYNONYMS GTP . 2Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-057-M005   5 mg 16.00 USD Add To Cart
ALX-480-057-M025   25 mg 33.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O14P3 . 2Li
MW: 519.2 . 13.9
CAS NUMBER: 85737-04-8 (free acid)
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Prepared by enzymatic phosphorylation of 5'-GMP. This salt form is much more stable than the sodium salt.
 
 
ALX-480-090 Revised 25-Jul-08
8-Hydroxy-2'-deoxyguanosine
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SYNONYMS 8-OHdG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-090-M001   1 mg 91.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O5
MW: 283.2
CAS NUMBER: 88847-89-6
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (15mg/ml) or DMSO (12mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column: E.M. Park, et al.; PNAS 89, 3375 (1992) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol. 9, 133 (1999) Abstract
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine: K. Asagoshi, et al.; J. Biol. Chem. 275, 4956 (2000) Abstract; Full Text
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells: E. Cappelli, et al.; Biochemistry 39, 10408 (2000) Abstract
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements: M.S. Cooke, et al.; Free Radic. Res. 32, 381 (2000) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-480-075 Revised 14-Jun-06
8-Hydroxyguanosine
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SYNONYMS 8-OHG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-075-M001   1 mg 30.00 USD Add To Cart
ALX-480-075-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O6
MW: 299.2
CAS NUMBER: 3868-31-3
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.
Product Specific Literature References
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS 89, 11021 (1992) Abstract
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res. 413, 143 (1998) Abstract
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med. 28, 13 (2000) Abstract
Further Categories Containing This Product:
Nucleic Acid Oxidation & Alkylation / Related Products
 
 
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