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DNA Regulation / Transcription
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ALX-215-027 Revised 21-Jul-06
Polyclonal Antibody to 14-3-3σ
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SYNONYMS anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-Stratifin PAb
anti-SFN PAb
anti-Epithelial Cell Marker Protein 1 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-027-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-10 (M1ERASLIQKA10C) of 14-3-3σ.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3σ.
APPLICATION: Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo: M.L. Henriksson, et al.; Eur. J. Biochem. 269, 4921 (2002) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-028 Revised 17-Aug-06
Polyclonal Antibody to 14-3-3τ
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SYNONYMS anti-14-3-3θ PAb
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-HS1 Protein PAb
anti-T Cell Protein PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-028-R100   100 µl 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-10 (M1EKTELIQKA10C) of 14-3-3τ.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3τ.
APPLICATION: ELISA
Immunohistochemistry (1:60)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein: H. Martin, et al.; FEBS Lett. 331, 296 (1993) Abstract; Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies: H. Martin, et al.; J. Neurochem. 63, 2259 (1994) Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain: Y. Patel, et al.; Biochim. Biophys. Acta 1222, 405 (1994) Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins: D.H. Jones, et al.; FEBS Lett. 368, 55 (1995) Abstract; Full Text
Expression and structural analysis of 14-3-3 proteins: D.H. Jones, et al.; J. Mol. Biol. 245, 375 (1995) Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation: C.P. Wheeler-Jones, et al.; Biochem. J. 315, 41 (1996) Abstract; Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain: M. Matto-Yelin, et al.; Mol. Biol. Cell 8, 1889 (1997) Abstract; Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease: J. Wiltfang, et al.; J. Neurochem. 73, 2485 (1999) Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants: A. Aitken; Plant Mol. Biol. 50, 993 (2002) Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain: H.C. Baxter, et al.; Neuroscience 109, 5 (2002) Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1: H.K. Chen, et al.; Cell 113, 457 (2003) Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein: P. Steinacker, et al.; Mol. Cell. Biol. 25, 1339 (2005) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-029 Revised 21-Jul-06
Polyclonal Antibody to 14-3-3ζ
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SYNONYMS anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-14-3-3δ PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-029-R100   100 µl 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-10 (M1DKNELVQKA10C) of 14-3-3ζ.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3ζ.
APPLICATION: ELISA
Immunohistochemistry (1:400)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein: H. Martin, et al.; FEBS Lett. 331, 296 (1993) Abstract; Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies: H. Martin, et al.; J. Neurochem. 63, 2259 (1994) Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain: Y. Patel, et al.; Biochim. Biophys. Acta 1222, 405 (1994) Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins: D.H. Jones, et al.; FEBS Lett. 368, 55 (1995) Abstract; Full Text
Expression and structural analysis of 14-3-3 proteins: D.H. Jones, et al.; J. Mol. Biol. 245, 375 (1995) Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation: C.P. Wheeler-Jones, et al.; Biochem. J. 315, 41 (1996) Abstract; Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain: M. Matto-Yelin, et al.; Mol. Biol. Cell 8, 1889 (1997) Abstract; Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease: J. Wiltfang, et al.; J. Neurochem. 73, 2485 (1999) Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants: A. Aitken; Plant Mol. Biol. 50, 993 (2002) Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain: H.C. Baxter, et al.; Neuroscience 109, 5 (2002) Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1: H.K. Chen, et al.; Cell 113, 457 (2003) Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein: P. Steinacker, et al.; Mol. Cell. Biol. 25, 1339 (2005) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-030 Revised 12-Feb-07
Polyclonal Antibody to 14-3-3
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SYNONYMS anti-pan-14-3-3 PAb
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY 14-3-3 Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-030-R100   100 µl 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN: Mixture of 14-3-3 isoforms isolated from sheep brain.
SPECIFICITY: Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3. Detects a band of ~28kDa by Western blot.
APPLICATION: Immunohistochemistry
Immunoprecipitation
Western Blot (1:2000)
Optimal condition must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo: M. Chaudhri, et al.; BBRC 300, 679 (2003) Abstract
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain: M. Matto-Yelin, et al.; Mol. Biol. Cell 8, 1889 (1997) Abstract; Full Text
Neurofibrillary tangles of Alzheimer’s disease brains contain 14-3-3 proteins: R. Layfield, et al.; Neurosci. Lett. 209, 57 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-037 Revised 01-Jul-08
Polyclonal Antibody to ART1 (human)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 1 (human) PAb
anti-CD296 (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-037-R100   100 µl 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of human ART1 (ecto-ADP-ribosyltransferase 1; CD296).
SPECIFICITY: Recognizes human ART1.
APPLICATION: Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation: F. Koch-Nolte, et al.; Cell. Immunol. 236, 66 (2005) Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003), (Review) Abstract; Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling: M. Seman, et al.; Curr. Med. Chem. 11, 857 (2004), (Review) Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells: F. Koch-Nolte, et al.; Ann. Med. 38, 188 (2006), (Review) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-038 Revised 01-Jul-08
Polyclonal Antibody to ART1 (mouse)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 1 (mouse) PAb
anti-CD296 (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-038-R100   100 µl 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of mouse ART1 (ecto-ADP-ribosyltransferase 1; CD296).
SPECIFICITY: Recognizes mouse ART1.
APPLICATION: Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation: F. Koch-Nolte, et al.; Cell. Immunol. 236, 66 (2005) Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003), (Review) Abstract; Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling: M. Seman, et al.; Curr. Med. Chem. 11, 857 (2004), (Review) Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells: F. Koch-Nolte, et al.; Ann. Med. 38, 188 (2006), (Review) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-039 Revised 01-Jul-08
Polyclonal Antibody to ART2.2 (mouse)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 2.2 (mouse) PAb
anti-ART2b (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-039-R100   100 µl 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of mouse ART2.2 (ecto-ADP-ribosyltransferase 2.2; ART2b).
SPECIFICITY: Recognizes mouse ART2.2.
APPLICATION: Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
Functional Application (blocking) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector: S. Adriouch, et al.; J. Immunol. 167, 196 (2001) Abstract; Full Text
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor: M. Seman, et al.; Immunity 19, 571 (2003) Abstract; Full Text
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation: F. Koch-Nolte, et al.; Cell. Immunol. 236, 66 (2005) Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003), (Review) Abstract; Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling: M. Seman, et al.; Curr. Med. Chem. 11, 857 (2004), (Review) Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells

: F. Koch-Nolte, et al.; Ann. Med. 38, 188 (2006), (Review) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-042 Revised 01-Jul-08
Polyclonal Antibody to ART4 (human)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 4 (human) PAb
anti-CD297 (human) PAb
anti-DO (human) PAb
anti-Dombrock Blood Group Carrier Molecule (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-042-R100   100 µl 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of human ART4 (ecto-ADP-ribosyltransferase 4; CD297).
SPECIFICITY: Recognizes human ART4.
APPLICATION: Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation: F. Koch-Nolte; Cell. Immunol. 236, 66 (2005), (Review) Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling: M. Seman, et al.; Curr. Med. Chem. 11, 857 (2004), (Review) Abstract
Complexities of the Dombrock blood group system revealed: M.E. Reid; Transfusion 45, 92S (2005), (Review) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-058 Revised 12-Sep-07
Polyclonal Antibody to HIF-2α (human)
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SYNONYMS anti-Hypoxia-inducible Factor 2α (human) PAb
anti-EPAS-1 (human) PAb
anti-Endothelial PAS Domain-containing Protein 1 (human) PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-058-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 426-443 of human HIF-2α (hypoxia-inducible factor 2α).
SPECIFICITY: Recognizes human HIF-2α. Detects a band of ~90kDa.
APPLICATION: Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Further Categories Containing This Product:
Aryl Hydrocarbon Receptor / Related Products • Polyclonal Antibodies
 
 
ALX-260-092 Revised 05-Jun-08
MG-132
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SYNONYMS Z-LLL-CHO
Z-Leu-Leu-Leu-CHO
PRODUCT LINE Ubiquitin & Proteasome
PRODUCT CATEGORY Proteasome / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-092-M001   1 mg 25.00 USD Add To Cart
ALX-260-092-M005   5 mg 60.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Leu-Leu-Leu-CHO
FORMULA: C26H41N3O5
MW: 475.6
CAS NUMBER: 133407-82-6
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by MS.
Product Description
Potent, reversible and cell permeable proteasome inhibitor. Inhibits NF-κB activation.
Product Specific Literature References
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell 78, 761 (1994) Abstract
Multiple proteolytic systems,