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ALX-380-261 Revised 04-Feb-08
Thiostrepton
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-261-G001   1 g 80.00 USD Add To Cart
ALX-380-261-G005   5 g 320.00 USD Add To Cart
Product Specification
FORMULA: C72H85N19O18S5
MW: 1664.9
CAS NUMBER: 1393-48-2
MERCK INDEX: 14: 9364
RTECS: XN6300100
SOURCE/HOST: Isolated from Streptomyces azureus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetic acid, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description
Thiazole-containing peptide antibiotic. Inhibits protein synthesis by preventing binding of GTP to the 50S ribosomal subunit. Inhibits binding of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome.
Product Specific Literature References
Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex: J.W. Bodley, et al.; BBRC 41, 1406 (1970) Abstract
Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA: U.R. Kutay, et al.; Biochim. Biophys. Acta 1050, 193 (1990) Abstract
Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome: S.P. Miller & J.W. Bodley; Nucl. Acids Res. 19, 1657 (1991) Abstract; Full Text
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton: P.C. Ryan, et al.; J. Mol. Biol. 221, 1257 (1991) Abstract
Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus: H. Malina & M. Robert-Gero; Appl. Environ. Microbiol. 58, 895 (1992) Abstract; Full Text
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A: G. Rosendahl & S. Douthwaite; Nucl. Acids Res. 22, 357 (1994) Abstract; Full Text
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome: M.V. Rodnina, et al.; PNAS 96, 9586 (1999) Abstract; Full Text
Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain: W.S. Bowen, et al.; J. Biol. Chem. 280, 2934 (2005) Abstract; Full Text
Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA: S.L. Bausch, et al.; J. Biol. Chem. 280, 29956 (2005) Abstract; Full Text
In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton: A. Garcia-Marcos, et al.; Nucl. Acids Res. 35, 7109 (2007) Abstract; Full Text
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
ALX-380-018 Revised 07-Feb-08
Tobramycin
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SYNONYMS Deoxykanamycin B
Distobram
Gernebcin
Obramycin
Tobradistin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-018-M010   10 mg 10.00 USD Add To Cart
ALX-380-018-M050   50 mg 30.00 USD Add To Cart
ALX-380-018-M250   250 mg 90.00 USD Add To Cart
ALX-380-018-G001   1 g 270.00 USD Add To Cart
Product Specification
FORMULA: C18H37N5O9
MW: 467.5
CAS NUMBER: 32986-56-4
MERCK INDEX: 14: 9490
RTECS: WK2100000
SOURCE/HOST: Isolated from Streptomyces tenebarius.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
FORMULATION: Free base.
SOLUBILITY: Soluble in water; very slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC. MAY BE TERATOGENIC.

Product Description
Aminoglycoside antibiotic with similar structure to the kanamycins and the gentamycins. Used in the treatment of respiratory infection and cystic fibrosis.
Product Specific Literature References
Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use: R. N. Brogden, et al.; Drugs 12, 166 (1976), Review Abstract
Inhaled tobramycin (TOBI): a review of its use in the management of Pseudomonas aeruginosa infections in patients with cystic fibrosis: S.M. Cheer, et al.; Drugs 63, 2501 (2003), Review Abstract
Tobramycin solution for inhalation in cystic fibrosis patients: a review of the literature: J.K. Hagerman, et al.; Expert Opin. Pharmacother. 8, 467 (2007), Review Abstract
 
 
ALX-380-279 Revised 08-Apr-08
Vancomycin . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-279-M250   250 mg 45.00 USD Add To Cart
ALX-380-279-G001   1 g 135.00 USD Add To Cart
Product Specification
FORMULA: C66H75Cl2N9O24 . HCl
MW: 1449.3 . 36.5
CAS NUMBER: 1404-93-9
MERCK INDEX: 14: 9929
RTECS: YW4380000
SOURCE/HOST: Isolated from Streptomyces lysosup.
APPEARANCE: White to light brown powder.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is >900µg/mg (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Glycopeptide antibiotic. Interferes with cell wall synthesis. Effective against Gram-positive bacteria.
Product Specific Literature References
Intravitreal injection of vancomycin in experimental staphylococcal endophthalmitis: P. Homer, et al.; Acta Ophthalmol. (Copenh) 53, 311 (1975) Abstract
Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine: G.M. Sheldrick, et al.; Nature 271, 223 (1978) Abstract
Hydrophobic interactions affect hydrogen bond strengths in complexes between peptides and vancomycin or ristocetin: M.P. Williamson & D.H. Williams; Eur. J. Biochem. 138, 345 (1984) Abstract
 
 
ALX-350-136 Revised 05-Dec-07
Viridicatin
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SYNONYMS 3-Hydroxy-4-phenyl-1H-chinolin-2-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-350-136-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C15H11NO2
MW: 237.3
CAS NUMBER: 129-24-8
SOURCE/HOST: Isolated from Penicillium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Metabolic product of Penicillium viridicatum. Exhibits strong antibiotic activity against M. tuberculosis and also against B. subtilis, S. aureus and S. cerevisiae.
Product Specific Literature References
The Isolation and some Chemical Properties of Viridicatin, a Metabolic Product of Penicillium viridicatum Westling: K.G. Cunningham and G.G. Freeman; Biochem J. 53, 328 (1953) Abstract
Determination of viridicatin in Penicillium cyclopium by capillary gas chromatography: G. Bringmann, et al.; Anal. Biochem. 253, 18 (1997) Abstract
The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station: A.G. Kozlovskii, et al.; Mikrobiologiia 71, 773 (2002), Russian Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-430-147 Revised 24-Oct-07
Virstatin
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SYNONYMS 4-(N-(1,8-Naphthalimide))-n-butyric acid
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-butanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-147-M010   10 mg 55.00 USD Add To Cart
ALX-430-147-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C16H13NO4
MW: 283.3
CAS NUMBER: 88909-96-0
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description

Inhibits virulence regulation in V. cholerae. Prevents expression of cholera toxin and the toxin coregulated pilus (TCP) by inhibiting the transcriptional regulator ToxT. Effectively protects infant mice against TCP-dependent V. cholerae intestinal colonization in vivo. Displays little toxicity towards mammalian cells (up to 2mM for Hep2 cells).
Product Specific Literature References
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization: D.T. Hung, et al.; Science 310, 670 (2005) Abstract
Virstatin inhibits dimerization of the transcriptional activator ToxT: E. A. Shakhnovich, et al.; PNAS 104, 2372 (2007) Abstract
 
 
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