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Nucleobases
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ALX-480-096 Revised 18-Aug-08
5-Aza-2'-deoxycytidine
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SYNONYMS 5-Aza-CdR
5-Aza-dC
5-Deoxy-2'-azacytidine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-096-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C8H12N4O4
MW: 228.2
CAS NUMBER: 2353-33-5
RTECS: XZ3012000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in DMSO or 50% acetic acid; 1mg/ml soluble in methanol. (Warming may be required to achieve complete solubilization.)
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
HAZARD: HARMFUL.

Product Description
Inhibitor of DNA methyltransferase. Restores mRNA and protein expression of caspase-8 and TRAIL (tumor necrosis factor-related apoptosis inducing ligand) sensitivity of resistant cell lines. Enhances apoptosis induced by HDAC (histone deacetylase) inhibitors.
Product Specific Literature References
Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice: J. Vesely and A. Cihak; Cancer Res. 37, 3684 (1977) Abstract
Cellular differentiation, cytidine analogs and DNA methylation: P.A. Jones and S.M. Taylor; Cell 20, 85 (1980) Abstract
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes: T. Haaf; Pharmacol. Ther. 65, 19 (1995) Abstract
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis: S. Hopkins-Donaldson, et al.; Cancer Res. 60, 4315 (2000) Abstract; Full Text
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression: A. Eggert, et al.; Cancer Res. 61, 1314 (2001) Abstract; Full Text
5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation: S. Takebayashi, et al.; BBRC 288, 921 (2001) Abstract
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors: W.G. Zhu, et al.; Cancer Res. 61, 1327 (2001) Abstract; Full Text
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products
 
 
ALX-480-091 Revised 28-Nov-07
8-Hydroxyguanine
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SYNONYMS 8-Oxoguanine
7,8-Dihydro-8-oxoguanine
8-oxoG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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ALX-480-091-M010   10 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C5H5N5O2
MW: 167.1
CAS NUMBER: 5614-64-2
PURITY: ≥90% (contains <10% acetic acid)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in conc. sodium hydroxide. May be further diluted and neutralized with water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer: P. Jaruga, et al.; FEBS Lett. 341, 59 (1994) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells: J.P. Spencer, et al.; FEBS Lett. 374, 233 (1995) Abstract
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions: T.H. Zastawny, et al.; Free Radic. Biol. Med. 18, 1013 (1995) Abstract
Oxidative denitrification of the antitumour drug hydroxyguanidine: S.A. Everett, et al.; Free Radic. Biol. Med. 24, 1 (1998) Abstract
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage: H.J. Helbock, et al.; Meth. Enzymol. 300, 156 (1999) Abstract
Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1: J.W. Hyun, et al.; Oncogene 19, 4476 (2000) Abstract
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme: N.Y. Tretyakova, et al.; Chem. Res. Toxicol. 13, 658 (2000) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-480-058 Revised 18-Jun-08
8-Nitroguanine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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ALX-480-058-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C5H4N6O3
MW: 196.1
CAS NUMBER: 168701-80-2
PURITY: ≥98% (HPLC)
SOLUBILITY: Slightly soluble in water (sonification).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination: V. Yermilov, et al.; FEBS Lett. 376, 207 (1995) Abstract
Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion: H. Ohshima, et al.; Free Radic. Biol. Med. 25, 1057 (1998) Abstract
Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo: J. Tuo, et al.; Free Radic. Biol. Med. 29, 147 (2000) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Oxidative Stress Markers & Reagents / Related Products
 
 
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