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ALX-210-436
Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
SYNONYMS
anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Forkhead Box [FOX] Proteins / Related Products
Ordering Information
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Unit Price:
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ALX-210-436-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY:
Recognizes both natural and recombinant mouse FOXP3. Detects a
band of ~46-49kDa by Western blot.
APPLICATION:
ELISA
(direct and indirect: 1:5’000-1:10’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3 / Related Products
•
Polyclonal Antibodies
ALX-210-532
Revised 31-Oct-06
Polyclonal Antibody to NF-ATc4 (human)
SYNONYMS
anti-Nuclear Factor of Activated T Cells, Cytoplasmic 4 (human) PAb
anti-NFAT3 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Factor of Activated T Cells [NF-AT]
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-532-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 887-902 (CR
887
DLSGFPAPPGEEPPA
902
) of human NF-ATc4 (nuclear factor of activated T cells, cytoplasmic 4). This sequence is 94% conserved in mouse NF-ATc4.
SPECIFICITY:
Recognizes human NF-ATc4. Detects a band of ~150kDa by Western blot.
APPLICATION:
Immunohistochemistry (1:3’000)
Western Blot (1:10’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells 5 (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-533
Revised 31-Oct-06
Polyclonal Antibody to NF-AT5 (human)
SYNONYMS
anti-Nuclear Factor of Activated T Cells 5 (human) PAb
anti-NFAT5 (human) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Factor of Activated T Cells [NF-AT]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-533-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1439-1455 (CD
1439
LLVSLQNQGNNLTGSF
1455
) of human NF-AT5 (nuclear factor of activated T cells 5). This sequence is 94% conserved in mouse NF-AT5.
SPECIFICITY:
Recognizes human NF-AT5. Detects a band of ~170kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:1'000)
Western Blot (1:2’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells 5 (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-577
Revised 26-May-08
Polyclonal Antibody to NF-ATc1
SYNONYMS
anti-Nuclear Factor of Activated T Cells, Cytoplasmic 1 PAb
anti-NFAT2 PAb
anti-NFATC PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Factor of Activated T Cells [NF-AT]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-577-C050
50 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
500µg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Recombinant N-terminal human NF-ATc1 fragment expressed as GST fusion protein.
SPECIFICITY:
Recognizes human NF-ATc1. Shows some cross-reactivity with mouse NF-ATc1.
CROSSREACTIVITY PROTEINS:
May contain some residual anti-GST activity.
APPLICATION:
Immunoprecipitation and Chromatin Immunoprecipitation (1:200)
Western Blot (1:500-1:1’000)
Functional Application: Band Shift Assay: competes with probe for NFAT binding.
The recommended dilutions refer to the analysis of cells and tissues with intermediate to high levels of NF-ATc1 and must be viewed as approximate. Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells:
M. Glazova, et al.; Brain Res. Mol. Brain Res.
138
, 116 (2005)
Abstract
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines:
M. Klein, et al.; J. Immunol.
177
, 6667 (2006)
Abstract
;
Full Text
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling:
A. Akimzhanov, et al.; Am. J. Pathol.
172
, 215 (2008)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-578
Revised 26-May-08
Polyclonal Antibody to NF-ATc2
SYNONYMS
anti-Nuclear Factor of Activated T Cells, Cytoplasmic 2 PAb
anti-NFAT1 PAb
anti-NFATP PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Factor of Activated T Cells [NF-AT]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-578-C020
20 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
200µg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Recombinant human NF-ATc2 protein fused to GST.
SPECIFICITY:
Recognizes human NF-ATc2.
CROSSREACTIVITY PROTEINS:
May contain some residual anti-GST activity.
APPLICATION:
Immunohistochemistry (formaldehyde fixed paraffin sections: 1:50)
Immunoprecipitation and Chromatin Immunoprecipitation (1:100)
Western Blot (1:500)
The recommended dilutions refer to the analysis of cells and tissues with intermediate to high levels of NF-ATc2 and must be viewed as approximate. Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines:
M. Klein, et al.; J. Immunol.
177
, 6667 (2006)
Abstract
;
Full Text
NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells:
E. Ulleras, et al.; Blood
111
, 3081 (2008)
Abstract
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling:
A. Akimzhanov, et al.; Am. J. Pathol.
172
, 215 (2008)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Note:
Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)
Gene Names: NFAT5
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-574
Revised 18-Oct-07
Polyclonal Antibody to NF-κB (p65)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-574-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human NF-κB (p65 subunit).
SPECIFICITY:
Recognizes human and mouse NF-κB (p65 subunit).
APPLICATION:
Immunocytochemistry (1:500-1:1’000)
Immunohistochemistry (paraffin sections (1:500-1:1’000))
Immunoprecipitation (2µg)
Western Blot (1:2’000-1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for one week when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1:
P.O. Hassa, et al.; J. Biol. Chem.
278
, 45145 (2003)
Abstract
;
Full Text
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription:
P.O. Hassa, et al.; J. Biol. Chem.
280
, 40450 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-576
Revised 18-Oct-07
Polyclonal Antibody to NF-κB (p50)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Transcription Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-576-R100
100 µl
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human NF-κB (p50 subunit).
SPECIFICITY:
Recognizes human NF-κB (p50 subunit).
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for one week when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
APO-54N-039
Revised 10-Oct-08
MDA5 (human) (IntraCellular) ELISA Kit
SYNONYMS
Melanoma Differentiation-associated Gene 5 (human) (IntraCellular) ELISA Kit
Helicard (human) (IntraCellular) ELISA Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
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APO-54N-039-KI01
1 Kit
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY:
0.4ng/ml (range 0.5 to 32ng/ml).
QUANTITY:
For 96 wells (~80 tests).
APPLICATION:
For the quantitative determination of human MDA5 in cell extracts.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-210-352
Polyclonal Antibody to MDA5 (mouse) (AL180)
ALX-210-935
Polyclonal Antibody to MDA5 (human) (AT113)
ALX-804-863
Monoclonal Antibody to MDA5 (human) (Hely-1)
APO-54N-035
MDA5 (human) (IntraCellular) Detection Set [For ELISA Application]
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Antiviral Signalling / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Interferons & Interferon Receptors Other Products
•
ELISA & EIA Kits
ALX-850-211
Revised 22-Apr-08
Caspase-1 Colorimetric Assay Kit
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Kits & Sets
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-850-211-KI01
25 tests
175.00 USD
Product Specification
KIT/SET CONTAINS:
25ml Cell Lysis Buffer, 2ml 2X Reaction Buffer, 125µl YVAD-
p
NA (1mM), 100µl DTT (1M), 25ml Dilution Buffer.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Store Cell Lysis Buffer, 2X Reaction Buffer and Dilution Buffer at 4°C after opening.
Product Description
Based on the spectrophotometric detection of the chromophore pNA (p-nitroaniline) after cleavage from the labelled substrate YVAD-pNA.
General Information
The pNA light emission can be quantified using a spectrophotometer or a microtiter plate reader at 400 or 405nm. Comparison of the absorbance of pNA from an treated sample with an untreated control allows determination of the fold increase in caspase-1 activity.
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Inflammasome
•
Activity Assays
ALX-850-212
Revised 21-Apr-08
Caspase-1 Fluorometric Assay Kit
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Kits & Sets
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-850-212-KI01
25 tests
175.00 USD
Product Specification
KIT/SET CONTAINS:
25ml Cell Lysis Buffer, 2ml 2x Reaction Buffer, 125µl YVAD-AFC Substrate (1mM), 100µl DTT (1M).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Store Cell Lysis Buffer and 2X Reaction Buffer at 4°C after opening.
Product Description
Based on the detection of AFC (7-amino-4-trifluoromethyl coumarin) after cleavage from the labelled substrate YVAD-AFC.
General Information
YVAD-AFC emits blue light (λmax = 400nm); upon cleavage of the substrate by caspase-1 or related caspases, free AFC emits a yellow-green fluorescence (λmax = 505nm), which can be quantified using a fluorometer or a fluorecence microtiter plate reader. Comparison of the fluorescence of AFC from a treated sample with an untreated control allows determination of the fold increase in caspase-1 activity.
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Inflammasome
•
Activity Assays
ALX-850-217
Revised 24-Jan-05
Caspase-5 Colorimetric Assay Kit
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Kits & Sets
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-217-KI01
25 tests
203.00 USD
Product Specification
