© 2008 Alexis Corporation
You are here:
Product Lines
>
Natural Products / Antibiotics
>
Natural Products
> Natural Products - Nitric Oxide Pathway Modulators
ALX-350-255
Revised 03-Apr-08
(+)-cis,trans-Abscisic acid
SYNONYMS
(S)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methyl-[2Z,4E]-pentadienoic acid
(+)-
cis
,
trans
ABA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Plant Research Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-255-C500
500 µg
90.00 USD
ALX-350-255-M001
1 mg
160.00 USD
ALX-350-255-M005
5 mg
620.00 USD
Product Specification
FORMULA:
C
15
H
20
O
4
MW:
264.3
CAS NUMBER:
21293-29-8
MERCK INDEX:
14:
11
SOURCE/HOST:
Isolated from
Curvularia lunata
.
PURITY:
≥97%
APPEARANCE:
Off-white powder.
SOLUBILITY:
Soluble in ethanol or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Natural and active isomer of the abscission accelerating plant hormone.
Product Specific Literature References
Metabolism and physiology of abscisic acid:
J.A.D. Zeevaart & R.A. Creelman; Annu. Rev. Plant Physiol. Plant Mol. Biol.
39
, 439 (1988), (Review)
Molecular responses to drought and cold stress:
K. Shinozaki & K. Yamaguchi-Shinozaki; Curr. Opin. Biotechnol.
7
, 161 (1996), (Review)
Abstract
Abscisic acid and signal transduction:
J. Leung & J. Giraudat; Annu. Rev. Plant Physiol. Plant Mol. Biol.
49
, 199 (1998), (Review)
ABA signal transduction:
E. Grill & A. Himmelbach; Curr. Opin. Plant Biol.
1
, 412 (1998), (Review)
Abstract
Signal transduction networks and the biology of plant cells:
M.J. Chrispeels, et al.; Biol. Res.
32
, 35 (1999), (Review)
Abstract
Abscisic acid:
A.M. Hetherington; Curr. Biol.
9
, R390 (1999), (Review)
Abstract
Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase
:
J. Li, et al.; Science
287
, 300 (2000)
Abstract
Mitogen-activated protein kinase and abscisic acid signal transduction:
S. Heimovaara-Dijkstra, et al.; Results Probl. Cell Differ.
27
, 131 (2000)
Abstract
Relay and control of abscisic acid signaling:
A. Himmelbach, et al.; Corr. Opin. Plant Biol.
6
, 470 (2003), Review
Abstract
Nitric oxide induced by hydrogen peroxide mediates abscisic acid-induced activation of the mitogen-activated protein kinase cascade involved in antioxidant defense in maize leaves:
A. Zhang, et al.; New Phytol.
175
, 36 (2007)
Abstract
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger:
S. Bruzzone, et al.; PNAS
104
, 5759 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators
•
Plant Research Reagents / Related Products
ALX-350-329
Revised 21-May-08
Allicin
SYNONYMS
2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-329-M001
1 mg
200.00 USD
ALX-350-329-M005
5 mg
690.00 USD
Product Specification
FORMULA:
C
6
H
10
OS
2
MW:
162.3
CAS NUMBER:
539-86-6
MERCK INDEX:
14:
261
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
Clear to slightly yellow liquid.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica:
S. Ankri, et al.; Antimicrob. Agents Chemother.
41
, 2286 (1997)
Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase:
V.M. Dirsch, et al.; Atherosclerosis
139
, 333 (1998)
Abstract
Antimicrobial properties of allicin from garlic:
S. Ankri & D. Mirelman; Microbes Infect.
1
, 125 (1999), Review
Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation:
K. Hirsch, et al.; Nutr. Cancer
38
, 245 (2000)
Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats:
A. Elkayam, et al.; Am. J. Hypertens.
14
, 377 (2001)
Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells:
L. Sun & X. Wang; World J. Gastroenterol.
9
, 1930 (2003)
Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells:
S. Oommen, et al.; Eur. J. Pharmacol.
485
, 97 (2004)
Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus:
R.R. Cutler & P. Wilson; Br. J. Biomed. Sci.
61
, 71 (2004)
Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin:
L.J. Macpherson, et al.; Curr. Biol.
15
, 929 (2005)
Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic:
S.R. Davis; Mycoses
48
, 95 (2005), Review
Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent:
R. Hunter, et al.; Ann. N.Y. Acad. Sci.
1056
, 234 (2005), Review
Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide:
L.Y. Chung; J. Med. Food
9
, 205 (2006)
Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial:
C.D. Gardner, et al.; Arch. Intern. Med.
167
, 346 (2007)
Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - Chemopreventive Agents
•
Antitumor Agents (Anti-proliferative)
•
Natural Products with Antibiotic Activity
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Apoptosis Inducers & Inhibitors
•
TRPV1 Agonists and Antagonists / Related Products
ALX-350-312
Revised 28-May-08
(-)-Arctigenin
SYNONYMS
(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3
H
)-furanone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-312-M025
25 mg
70.00 USD
Product Specification
FORMULA:
C
21
H
24
O
6
MW:
372.4
CAS NUMBER:
7770-78-7
SOURCE/HOST:
Isolated from
Arctium lappa
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (34mg/ml, heating, sonication); sparingly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-X
L
. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells. Antagonist for platelet activating factor and Ca
2+
. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
Product Specific Literature References
Antiproliferative effect of Arctigenin and Arctiin:
S.Y. Ryu, et al.; Arch. Pharm. Res.
18
, 462 (1995)
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase:
E. Eich, et al.; J. Med. Chem
39
, 86 (1996)
Abstract
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation:
J.Y. Cho, et al.; J. Pharm. Pharmacol.
51
, 1267 (1999)
Abstract
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor:
Y.P. Jang, et al.; J. Neurosci. Res. 68, 233 (2002)
68
, 233 (2002)
Abstract
A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris:
A. Koulman, et al.; Planta Med.
69
, 733 (2003)
Abstract
Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells:
B. Hausott, et al.; J. Cancer Res. Clin. Oncol.
129
, 569 (2003)
Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition:
M.K. Cho, et al.; Int. Immunopharmacol.
4
, 1419 (2004)
Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition:
M.K. Cho, et al.; Int. Immunopharmacol.
4
, 1419 (2004)
Abstract
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation:
S. Awale, et al.; Cancer Res.
66
, 1751 (2006)
Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme:
K. Kang, et al.; Biol. Pharm. Bull.
30
, 2352 (2007)
Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
Platelet Activating Factors [PAF] & Receptors / Related Products
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Nitric Oxide Pathway Modulators
•
HIV / AIDS / Related Products
ALX-350-219
Revised 28-May-08
Artemisinin
SYNONYMS
Qinghaosu
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antimalarial Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-219-M100
100 mg
35.00 USD
ALX-350-219-G001
1 g
220.00 USD
Product Specification
FORMULA:
C
15
H
22
O
5
MW:
282.4
CAS NUMBER:
63968-64-9
MERCK INDEX:
14:
817
SOURCE/HOST:
Isolated from the traditional Chinese anti-malarial herb
Artemisia annua
L.
PURITY:
≥98%
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO, chloroform or acetone; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
HAZARD:
TOXIC.
Product Description
Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).
Product Specific Literature References
Qinghaosu (artemisinin): an antimalarial drug from China:
D.L. Klayman; Science
228
, 1049 (1985)
Abstract
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives:
X.D. Luo & C.C. Shen; Med. Res. Rev.
7
, 29 (1987)
Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin
:
M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol.
445
, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication:
M.A. van Agtmael, et al.; Trends Pharmacol. Sci.
20
, 199 (1999), Review
Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation:
E. Aldieri, et al.; FEBS Lett.
552
, 141 (2003)
Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies:
M. Wartenberg, et al.; Lab. Invest.
83
, 1647 (2003)
Abstract
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb:
Y. Li & Y.L. Wu; Curr. Med. Chem.
10
, 2197 (2003), Review
Abstract
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements:
R.K. Haynes; Curr. Top. Med. Chem.
6
, 509 (2006), Review
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products for Angiogenesis Research
•
Natural Products - Nitric Oxide Pathway Modulators
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Malaria / Related Products
ALX-350-144
Revised 03-Apr-08
Bakuchiol
SYNONYMS
4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-144-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
18
H
24
O
MW:
256.4
CAS NUMBER:
10309-37-2
SOURCE/HOST:
Isolated from plant
Psoralea corylifolia
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brownish oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids:
M.E. Wall, et al.; J. Nat. Prod.
51
, 1084 (1988)
Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia:
N.J. Sun, et al.; J. Nat. Prod.
61
, 362 (1998)
Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia:
H. Haraguchi, et al.; Planta Med.
66
, 569 (2000)
Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities:
C.N. Backhouse, et al.; J. Ethnopharmacol.
78
, 27 (2001)
Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells:
H. Cho, et al.; Planta Med.
67
, 750 (2001)
Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms:
H. Katsura, et al.; Antimicrob. Agents Chemother.
45
, 3009 (2001)
Abstract
;
Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages:
H.O. Pae, et al.; Int. Immunopharmacol.
1
, 1849 (2001)
Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae):
H. Haraguchi, et al.; Phytother. Res.
16
, 539 (2002)
Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis:
S.M. Newton, et al.; J. Ethnopharmacol.
79
, 57 (2002)
Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain:
S. Adhikari, et al.; Chem. Res. Toxicol.
16
, 1062 (2003)
Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent:
K. Bapat, et al.; Appl. Radiat. Isot.
62
, 389 (2005)
Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia:
Y.C. Kim, et al.; Planta Med.
71
, 87 (2005)
Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo:
E.J. Park, et al.; Planta Med.
71
, 508 (2005)
Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts:
E.J. Park, et al.; Eur. J. Pharmacol.
559
, 115 (2007)
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - DNA Replication Inhibitors
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Topoisomerase Inhibitors
•
Natural Products with Antibiotic Activity
•
Protein Tyrosine Phosphatases Other Products
•
Lipid Peroxidation
•
Natural Products - Antioxidants
ALX-270-480
Revised 10-Mar-08
Caffeic acid ethyl ester
SYNONYMS
CAEE
Ethyl caffeate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-480-M050
50 mg
20.00 USD
ALX-270-480-M250
250 mg
60.00 USD
Product Specification
FORMULA:
C
11
H
12
O
4
MW:
208.2
CAS NUMBER:
66648-50-8
SOURCE/HOST:
Synthetic.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt when stored at -20°C.
HANDLING:
Protect from light and moisture.
Product Description
Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC
50
=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E
2
(PGE
2
) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H
2
O
2
.
Product Specific Literature References
Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells:
T. Nakayama, et al.; Biosci. Biotechnol. Biochem.
60
, 316 (1996)
Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin:
Y.M. Chiang, et al.; Br. J. Pharmacol.
146
, 352 (2005)
Abstract
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines:
M. Cardenas, et al.; Bioorg. Med. Chem.
14
, 2966 (2006)
Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR:
K. Suzuki, et al.; Biofactors
28
, 151 (2006)
Abstract
Related Products
ALX-270-231
Caffeic acid
ALX-270-244
Caffeic acid phenylethyl ester
Further Categories Containing This Product:
Prostaglandins Other Products
•
Natural Products - Chemopreventive Agents
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Nitric Oxide Pathway Modulators
•
Phenolic Acids
•
NF-kB Pathway Inhibitors
ALX-350-278
Revised 08-Apr-08
Caffeic acid n-octyl ester
SYNONYMS
n-Octylcaffeate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-278-M005
5 mg
25.00 USD
ALX-350-278-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
17
H
24
O
4
MW:
292.2
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
More potent analog than CAPE (Prod. No.
ALX-270-244
). Suppressor of inducible nitric oxide synthase (iNOS; NOS II). Induces apoptosis.
Product Specific Literature References
Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids:
B. Etzenhouser, et al.; Bioorg. Med. Chem.
9
, 199 (2001)
Abstract
A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
:
G. Hsiao, et al.; Biochem. Pharmacol.
65
, 1383 (2003)
Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties:
F.M. da Cunha, et al.; Free Radic. Res.
38
, 1241 (2004)
Abstract
Octylcaffeate induced apoptosis in human leukemia U937 cells:
M. Ujibe, et al.; Biol. Pharm. Bull.
28
, 2338 (2005)
Abstract
General Information
Octylcaffeate significantly ameliorates circulatory failure of endotoxemia by suppression of iNOS (NOS II) expression through inactivation of mitogen-activated protein kinases.
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
NF-kB Pathway Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Antioxidants
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Phenolic Acids
ALX-350-015
Revised 02-Dec-08
(S)-(+)-Camptothecin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Topoisomerase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-015-M050
50 mg
40.00 USD
ALX-350-015-M250
250 mg
150.00 USD
ALX-350-015-G001
1 g
295.00 USD
Product Specification
FORMULA:
C
20
H
16
N
2
O
4
MW:
348.4
CAS NUMBER:
7689-03-4
MERCK INDEX:
14:
1735
RTECS:
UQ0492000
SOURCE/HOST:
Isolated from
Mappia foetida
Miers (
Nothapodytes foetida
(Wt.) Sleumer).
PURITY:
≥98% (HPLC)
APPEARANCE:
Pale yellow powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml), methanol (40mg/ml) or 0.1N sodium hydroxide (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture. After reconstitution, prepare aliquots and store at -20°C.
HAZARD:
TOXIC.
Product Description
Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Suppresses nitric oxide (NO) biosynthesis.
Product Specific Literature References
M.E. Wall, et al.; JACS
88
, 3888 (1966)
The current status of camptothecin analogues as antitumor agents:
W.J. Slichenmyer, et al.; J. Natl. Cancer Inst.
85
, 271 (1993), (Review)
Abstract
RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells:
J.L. Janavs, et al.; Mol. Brain Res.
23
, 47 (1994)
Abstract
Camptothecins: from bench research to hospital wards:
M. Potmesil; Cancer Res.
54
, 1431 (1994), (Review)
Abstract
Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells:
J.L. Janavs, et al.; J. Neurosci.
15
, 298 (1995)
Abstract
Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives:
A. Tanizawa, et al.; Biochemistry
34
, 7200 (1995)
Abstract
The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription:
M. Ljungman & P.C. Hanawalt; Carcinogenesis
17
, 31 (1996)
Abstract
The cell cycle effects of camptothecin:
Z. Darzynkiewicz, et al.; Ann. N. Y. Acad. Sci.
803
, 93 (1996)
Abstract
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases:
T. Shimizu & Y. Pommier; Leukemia
11
, 1238 (1997)
Abstract
Camptothecin and taxol: discovery to clinic:
M.E. Wall; Med. Res. Rev.
18
, 299 (1998), Review
Abstract
Camptothecin suppresses nitric oxide biosynthesis in RAW 264.7 macrophages:
W.F. Chiou, et al.; Life Sci.
69
, 625 (2001)
Abstract
Reversal of multidrug resistance-associated protein-mediated daunorubicin resistance by camptothecin:
D. Chauvier, et al.; J. Pharm. Sci.
91
, 1765 (2002)
Abstract
Camptothecin and taxol: historic achievements in natural products research:
N.H. Oberlies & D.J. Kroll; J. Nat. Prod.
67
, 129 (2004), Review
Abstract
Camptothecin and its analogues: a review on their chemotherapeutic potential:
D. Sriram, et al.; Nat. Prod. Res.
19
, 393 (2005), Review
Abstract
The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I::
G. Capranico, et al.; Biochimie
89
, 482 (2007)
Abstract
Related Products
ALX-350-133
Topotecan . hydrochloride
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
•
MDR Inhibitors
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Antitumor Reagents
•
p53 Other Products
•
Alkaloids
ALX-350-002
Revised 11-Nov-08
Canavanine . sulfate
SYNONYMS
L-α-Amino-γ-(guanidinooxy)-n-butyric acid . sulfate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Nitric Oxide Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-002-M100
100 mg
25.00 USD
ALX-350-002-M500
500 mg
95.00 USD
Product Specification
FORMULA:
C
5
H
12
N
4
O
3
. H
2
SO
4
MW:
176.2 . 98.1
CAS NUMBER:
2219-31-0
MERCK INDEX:
14:
1737
PURITY:
≥99% (TLC)
APPEARANCE:
White to-off white powder.
SOLUBILITY:
Soluble in water (100mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by IR.
Product Description
The non-protein amino acid L-canavanine is an analog of L-arginine. Selective inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Induces apoptotic cell death and shows antiproliferative and immunotoxic effects.
Product Specific Literature References
Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine:
D.S. Swaffar, et al.; Cancer Res.
54
, 6045 (1994)
Abstract
Inhibition of nitric oxide formation with L-canavanine attenuates endotoxin-induced vascular hyporeactivity in the rat:
M. Cai, et al.; Eur. J. Pharmacol.
295
, 215 (1996)
Abstract
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, during rodent endotoxaemia:
L. Liaudet, et al.; Clin. Sci. (London)
90
, 369 (1996)
Abstract
Effects of L-canavanine, an inhibitor of inducible nitric oxide synthase, on endotoxin mediated shock in rats:
Z. Fatehi-Hassanabad, et al.; Shock
6
, 194 (1996)
Abstract
L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines:
D.R. Worthen, et al.; Cancer Lett.
132
, 229 (1998)
Abstract
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats:
B. Levy, et al.; Shock
11
, 98 (1999)
Abstract
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with end
