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STATs / Related Products
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ALX-804-577 Revised 03-May-06
Monoclonal Antibody to STAT1 (human) (phosphorylated) (pSer727) (PSM1)
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SYNONYMS anti-Signal Transducer and Activator of Transcription 1-α/β (human) (phosphorylated) (pSer727) MAb (PSM1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-577-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: PSM1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 721-733 (D721NLLPMpSP
EEFDE733) of human STAT1 phosphorylated at Ser727.
SPECIFICITY: Recognizes human STAT1. Cross-reactivity with other species has not been tested.
APPLICATION: Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation: J. Kovarik, et al.; Int. J. Mol. Med. 12, 335 (2003) Abstract
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-804-576 Revised 10-Mar-05
Monoclonal Antibody to STAT1 (human) (SM2)
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SYNONYMS anti-Signal Transducer and Activator of Transcription 1-α/β (human) MAb (SM2)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-576-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: SM2
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A-affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 9-23 (Q9LDSKFLEQVH
QLYD23) of human STAT1.
SPECIFICITY: Recognizes human STAT1. Other species have not been tested.
APPLICATION: Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-180 Revised 05-Jun-07
Monoclonal Antibody to STAT3 (phosphorylated) (pTyr705) (9E12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-180-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE: 9E12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of STAT3 phosphorylated at Tyr705.
SPECIFICITY: Recognizes the -AAPpYLKT-motif of activated human, mouse and dog STAT3 phosphorylated at Tyr705. Does not cross-react with the non-phosphorylated form of STAT3 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION: Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot (0.1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-025).
General Information
The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies
 
 
ALX-804-239 Revised 05-Jun-07
Monoclonal Antibody to STAT6 (human) (8C12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-239-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 8C12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to aa 630-650 of human STAT6.
SPECIFICITY: Recognizes human STAT6. Detects a band of ~97kDa by Western blot.
APPLICATION: Immunohistochemistry
Western Blot (1µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Upon reconstitution, prepare aliquots and freeze in liquid nitrogen; reconstituted antibody can be stored frozen at -80°C up to 1 year. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-030).
Further Categories Containing This Product:
Monoclonal Antibodies • Autophagy Other Products
 
 
ALX-804-272 Revised 13-Jun-08
Monoclonal Antibody to STAT6 (phosphorylated) (pTyr641) (16E12)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY STATs / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-272-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 16E12
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15 min., RT).
IMMUNOGEN: Synthetic peptide corresponding to a portion of human STAT6 phophorylated at Tyr641.
SPECIFICITY: Recognizes the GRGpYVPA motif of human, mouse (weak) and rat (weak) activated STAT6 phosphorylated at Tyr641. Does not cross-react with the non-phosphorylated form of STAT6 nor with unrelated tyrosine-phosphorylated proteins.
APPLICATION: Immunohistochemistry
Western Blot (1HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4’000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL: Included (Prod. No. ALX-840-018).
Product Specific Literature References
IL-4-induced priming of human intestinal mast cells for enhanced survival and Th2 cytokine generation is reversible and associated with increased activity of ERK1/2 and c-Fos: A. Lorentz, et al.; J. Immunol. 174, 6751 (2005) Abstract; Full Text
General Information
STATs (signal transducing activators of transcription) are mediators involved in cytokine signalling. In response to a specific cytokine signal, STATs move to the nucleus and induce transcription. STAT6 is activated primarily by IL-4 and IL-13. Upon activation, STAT6 is phosphorylated at tyrosine 641 by Janus Kinases (JAKs). Phosphorylated STAT6 forms head-to-tail heterodimers and translocates to the nucleus where it participates in transcriptional control.
Further Categories Containing This Product:
Phospho-specific Antibodies • Monoclonal Antibodies • Autophagy Other Products
 
 
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