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14-3-3 Proteins / Related Products
Circadian Transcriptional Regulators / Related Products
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ALX-480-096
Revised 18-Aug-08
5-Aza-2'-deoxycytidine
SYNONYMS
5-Aza-CdR
5-Aza-dC
5-Deoxy-2'-azacytidine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Nucleobases
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ALX-480-096-M005
5 mg
240.00 USD
Product Specification
FORMULA:
C
8
H
12
N
4
O
4
MW:
228.2
CAS NUMBER:
2353-33-5
RTECS:
XZ3012000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
25mg/ml soluble in DMSO or 50% acetic acid; 1mg/ml soluble in methanol. (Warming may be required to achieve complete solubilization.)
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
HAZARD:
HARMFUL.
Product Description
Inhibitor of DNA methyltransferase. Restores mRNA and protein expression of caspase-8 and TRAIL (tumor necrosis factor-related apoptosis inducing ligand) sensitivity of resistant cell lines. Enhances apoptosis induced by HDAC (histone deacetylase) inhibitors.
Product Specific Literature References
Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice
:
J. Vesely and A. Cihak; Cancer Res.
37
, 3684 (1977)
Abstract
Cellular differentiation, cytidine analogs and DNA methylation
:
P.A. Jones and S.M. Taylor; Cell
20
, 85 (1980)
Abstract
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes
:
T. Haaf; Pharmacol. Ther.
65
, 19 (1995)
Abstract
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
:
S. Hopkins-Donaldson, et al.; Cancer Res.
60
, 4315 (2000)
Abstract
;
Full Text
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
:
A. Eggert, et al.; Cancer Res.
61
, 1314 (2001)
Abstract
;
Full Text
5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation
:
S. Takebayashi, et al.; BBRC
288
, 921 (2001)
Abstract
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors
:
W.G. Zhu, et al.; Cancer Res.
61
, 1327 (2001)
Abstract
;
Full Text
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products
ALX-480-019
Revised 17-Nov-08
O6-Benzylguanine
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA & RNA Methyl & Alkyl Transferases / Related Products
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Format:
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ALX-480-019-M010
10 mg
30.00 USD
ALX-480-019-M050
50 mg
95.00 USD
Product Specification
FORMULA:
C
12
H
11
N
5
O
MW:
241.2
CAS NUMBER:
19916-73-5
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol (20mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
IRRITANT.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Effective substrate and efficient inactivator of DNA alkyltransferase.
Product Specific Literature References
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA
:
K. Goodtzova, et al.; Biochemistry
33
, 8385 (1994)
Abstract
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine
:
R.H. Elder, et al.; Biochem. J.
298
, 231 (1994)
Abstract
O6-benzylguanine and its role in chemotherapy:
M.E. Dolan & A.E. Pegg; Cancer Res.
3
, 837 (1997)
Abstract
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo:
E.L. Kreklau, et al.; Pharmacol. Exp. Ther.
291
, 1269 (1999)
Abstract
ALX-350-014
Revised 03-Apr-08
Calyculin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-014-C010
10 µg
65.00 USD
ALX-350-014-C025
25 µg
110.00 USD
ALX-350-014-C050
50 µg
190.00 USD
ALX-350-014-C100
100 µg
320.00 USD
Product Specification
FORMULA:
C
50
H
81
N
4
O
15
P
MW:
1009.2
CAS NUMBER:
101932-71-2
SOURCE/HOST:
Isolated from
Discodermia calyx
.
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol, acetonitrile, chloroform, methylene chloride or benzene. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
May by subject to isomerization when in solution. Biological activity is not affected by isomerization.
HANDLING:
Protect from light and moisture.
HAZARD:
TOXIC. MAY BE CARCINOGENIC.
Product Description
Potent cell permeable inhibitor with high specificity for protein phosphatase 1 (PP1) and 2A (PP2A). Inhibits p130cas tyrosine phosphorylation. Enhances the phosphorylation level of NF-κB. Affects intracellular signalling processes that require 14-3-3. Potent non-phorbol type tumor promoter. Prevents γ-radiation induced apoptosis.
Product Specific Literature References
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate- type tumor promoter:
M. Suganuma, et al.; PNAS
85
, 1768 (1988)
Abstract
Protein phosphatases come of age:
P.Cohen & P.T. Cohen; J. Biol. Chem.
264
, 21435 (1989)
Abstract
;
Full Text
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity:
H. Ishihara, et al.; BBRC
159
, 871 (1989)
Abstract
The structure and regulation of protein phosphatases:
P. Cohen; Ann. Rev. Biochem.
58
, 453 (1989)
Abstract
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin:
M. Suganuma, et al.; Cancer Res.
50
, 3521 (1990)
Abstract
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C:
R. Gopalakrishna; BBRC
189
, 950 (1992)
Abstract
Comparative effects of protein phosphatase inhibitors (okadaic acid and calyculin A) on human leukemia HL60, HL60/ADR and K562 cells:
K. Sakurada, et al.; BBRC
187
, 488 (1992)
Abstract
Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis:
Q. Song & M.F. Lavin; BBRC
190
, 47 (1993)
Abstract
Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices:
A. Figurov, et al.; Eur. J. Neurosci.
5
, 1035 (1993)
Abstract
Calyculin A, a non-phorbol ester type tumor promotor, induced oxidative DNA damage in stimulated human neutrophil-like cells:
T. Takeuchi, et al.; BBRC
205
, 1803 (1994)
Abstract
Potassium and calcium channel involvement in induction of long-lasting synaptic enhancement by calyculin A, a protein phosphatase inhibitor, in rat hippocampal CA1 region:
N. Murakami, et al.; Neurosci. Lett.
176
, 181 (1994)
Abstract
Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A:
M.T. Runnegar, et al.; J. Pharmacol. Exp. Ther.
273
, 545 (1995)
Abstract
Inhibition of p130cas tyrosine phosphorylation by calyculin A:
W. Qiu, et al.; J. Leukoc. Biol.
63
, 631 (1998)
Abstract
Unique features of the okadaic acid activity class of tumor promoters:
H. Fujiki & M. Suganuma; J. Cancer Res. Clin. Oncol.
125
, 150 (1999), Review
Abstract
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo:
G. Tzivion, et al.; J. Biol. Chem.
275
, 29772 (2000)
Abstract
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells:
H. Tanaka, et al.; Int. J. Oncol.
31
, 389 (2007)
Abstract
Further Categories Containing This Product:
PP2A / Related Products
•
PP1 / Related Products
•
Natural Products - Other Tumor Promoters
•
14-3-3 Proteins / Related Products
•
Carcinogens & Tumor Promoters Other Products
•
NF-kB Pathway Modulators
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Marine Natural Products
ALX-380-242
Revised 03-Apr-08
Chaetocin (high purity)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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ALX-380-242-M001
1 mg
330.00 USD
Product Specification
FORMULA:
C
30
H
28
N
6
O
6
S
4
MW:
696.9
CAS NUMBER:
28097-03-2
RTECS:
FM3032000
SOURCE/HOST:
Isolated from
Chaetomium
sp. MST-FP2085.
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol or 100% ethanol; poorly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Antitumor antibiotic. Specific inhibitor of the lysine-specific methyltransferase SU(VAR)3-9 both
in vitro
and
in vivo
.
Product Specific Literature References
Isolation and configuration of Chaetocin:
D. Hauser, et al.; Helv. Chim. Acta.
53
, 1061 (1970)
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9:
D. Greiner, et al.; Nat. Chem. Biol.
1
, 143 (2005)
Abstract
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress:
C.R. Isham, et al.; Blood
109
, 2579 (2007)
Abstract
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products
ALX-550-516
Revised 21-May-08
Compound A
SYNONYMS
CpdA
2-((4-Acetophenyl)-2-chloro-
N
-methyl)ethylammonium chloride
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
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ALX-550-516-M005
5 mg
40.00 USD
ALX-550-516-M025
25 mg
120.00 USD
Product Specification
FORMULA:
C
11
H
14
ClNO
2
. HCl
MW:
227.7 . 36.5
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stock solutions in ethanol are stable for up to 1 month when stored at -80°C.
HANDLING:
Protect from moisture. After reconstitution, prepare aliquots and store at -80°C.
Product Description
Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No.
ALX-370-002
) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes
in vivo
.
Product Specific Literature References
A fully dissociated compound of plant origin for inflammatory gene repression:
K. De Bosscher, et al.; PNAS
102
, 15827 (2005)
Abstract
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis:
P. Dewint, et al.; J. Immunol.
180
, 2608 (2008)
Abstract
Related Products
ALX-370-002
Dexamethasone
Further Categories Containing This Product:
GITR & GITRL Other Products
•
Glucocorticoids & Glucocorticoid Receptors / Related Products
•
RANK & RANKL / OPG Other Products
•
Natural Products - Nitric Oxide Pathway Modulators
•
DNA & RNA Methyl & Alkyl Transferases / Related Products
•
Antitumor Agents (Hormone-related)
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - Chemopreventive Agents
•
Other Natural Products - DNA Regulation / Transcription
•
Natural Products for Cell Cycle Research
ALX-370-002
Revised 19-Sep-06
Dexamethasone
SYNONYMS
9α-Fluoro-16α-methylprednisolone
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
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ALX-370-002-M250
250 mg
22.00 USD
ALX-370-002-G001
1 g
45.00 USD
Product Specification
FORMULA:
C
22
H
29
FO
5
MW:
392.5
CAS NUMBER:
50-02-2
MERCK INDEX:
14:
2943
RTECS:
TU3980000
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol. Slightly soluble in acetone or chloroform. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
HARMFUL. MAY BE TERATOGENIC.
Product Description
Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Glucocorticoid with anti-inflammatory activity. Inhibits the induction of nitric oxide synthases (NOS).
Product Specific Literature References
Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?:
S. Moncada & R.M.J. Palmer; TIPS
12
, 130 (1991), (Review)
Abstract
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells:
K.J. O'Connor & S. Moncada; Biochim. Biophys. Acta
1097
, 227 (1991)
Abstract
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells:
C. Estrada, et al.; BBRC
186
, 475 (1992)
Abstract
Dexamethasone inhibits the expression of an inducible nitric oxide synthase in infarcted rabbit myocardium:
R.R. Dudek, et al.; BBRC
202
, 1120 (1994)
Abstract
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes:
T. Grombacher, et al.; Carcinogenesis
17
, 2329 (1996)
Abstract
Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone:
T. Biswas, et al.; Oncogene
18
, 525 (1999)
Abstract
Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases:
M.G. Cifone, et al.; Blood
93
, 2282 (1999)
Abstract
;
Full Text
Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2:
M.S. Montani, et al.; Cell Death Differ
6
, 79 (1999)
Abstract
Dexamethasone inhibits the phosphorylation of retinoblastoma protein in the suppression of human vascular smooth muscle cell proliferation:
T.D. Reil, et al.; J. Surg. Res.
92
, 108 (2000)
Abstract
Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells:
M. Matsumura, et al.; Life Sci.
69
, 1067 (2001)
Abstract
Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages:
R. Korhonen, et al.; Mol. Pharmacol.
62
, 698 (2002)
Abstract
;
Full Text
Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells:
J. Shinoda, et al.; Glia
42
, 68 (2003)
Abstract
Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line:
A.L. Vital, et al.; Mediators Inflamm.
12
, 71 (2003)
Abstract
Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles:
S.C. Schafer, et al.; Am. J. Physiol. Heart Circ. Physiol.
288
, H436 (2005)
Abstract
;
Full Text
Related Products
ALX-550-516
Compound A
Further Categories Containing This Product:
GITR & GITRL Other Products
•
RANK & RANKL / OPG Other Products
•
Antitumor Agents (Hormone-related)
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Chemopreventive Agents Other Products
•
DNA & RNA Methyl & Alkyl Transferases / Related Products
•
Cell Cycle Other Products
ALX-350-115
Revised 21-Feb-08
Fusicoccin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Plant Research Reagents
Ordering Information
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ALX-350-115-MC05
0.5 mg
70.00 USD
ALX-350-115-M001
1 mg
120.00 USD
Product Specification
FORMULA:
C
36
H
56
O
12
MW:
680.8
CAS NUMBER:
20108-30-9
SOURCE/HOST:
Isolated from fungus
Fusicoccum amygdali.
PURITY:
≥90% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in acetone, 100% ethanol, methanol, chloroform or ethyl acetate; practically insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
Diterpene glucoside with numerous effects on plants. Induces H
+
extrusion from plant cells by 14-3-3-dependent activation of the plasma membrane H
+
-ATPase. Stimulates cell enlargement, ion uptake, seed germination, opening the stomata, etc. Markedly reduces the cell’s capability for H
2
O
2
scavenging.
Product Specific Literature References
Fusicoccin - a key to multiple 14-3-3 locks?
:
A.H. De Boer; Trends Plant Sci.
2
, 20 (1997)
Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor:
C. Olivari, et al.; Plant Physiol.
116
, 529 (1998)
Abstract
Cytoskeletal inhibitors suppress the stomatal opening of Vicia faba L. induced by fusicoccin and IAA:
R.F. Huang, et al.; Plant Sci.
156
, 65 (2000)
Abstract
Inhibition of catalase activity as an early response of Arabidopsis thaliana cultured cells to the phytotoxin fusicoccin:
N. Beffagna & I. Lutzu; J. Exp. Bot.
58
, 4183 (2007)
Abstract
General Literature References
Fusicoccin: a tool in plant physiology
:
E. Marre; Ann. Rev. Plant Physiol.
30
, 273 (1979), (Review)
Fusicoccin receptors: perception and transduction of the fusicoccin signal
:
P. Aducci et al.; J. Exp. Bot.
46
, 1463 (1995), (Review)
Fusicoccin - a key to multiple 14-3-3 locks?
:
A.H. De Boer; Trends Plant Sci.
2
, 20 (1997), (Review)
Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor:
C. Olivari, et al.; Plant Physiol.
116
, 529 (1998)
Abstract
Phosphorylation-independent interaction between 14-3-3 protein and the plant plasma membrane H+-ATPase
:
J. Borch, et al.; Biochem. Soc. Trans.
30
, 411 (2002), (Review)
Abstract
;
Full Text
Plant 14-3-3 proteins assist ion channels and pumps
:
A.H. de Boer; Biochem. Soc. Trans.
30
, 416 (2002), (Review)
Abstract
;
Full Text
Metabolic enzymes as targets for 14-3-3 proteins
:
S.C. Huber, et al.; Plant Mol. Biol.
50
, 1053 (2002), (Review)
Abstract
cDNA microarray analysis of fusicoccin-induced changes in gene expression in tomato plants:
U.B. Frick & A. Schaller; Planta
216
, 83 (2002)
Abstract
Mutational analysis of the interaction between 14-3-3 proteins and plant plasma membrane H+-ATPase:
S. Visconti, et al.; J. Biol. Chem.
278
, 8172 (2003)
Abstract
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex:
M. Wurtele, et al.; Embo J.
22
, 987 (2003)
Abstract
Further Categories Containing This Product:
H+-ATPase / Related Products
•
14-3-3 Proteins / Related Products
•
Plant Research Reagents / Related Products
ALX-201-065
Revised 18-Sep-08
MGMT (human) (recombinant)
SYNONYMS
O
6
-Methylguanine-DNA Methyltransferase (human) (recombinant)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA Repair Other Products
Ordering Information
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ALX-201-065-R050
50 µl
320.00 USD
Product Specification
EC:
2.1.1.63
SOURCE/HOST:
Produced in
E. coli
. Full length human MGMT is fused at the N-terminus to a GST-tag.
PURITY:
Purified with Glutathiose-Sepharose 4B and thrombin cleavage
FORMULATION:
Liquid. 5'000U in 50µl buffer containing 50% glycerol, 100µg/ml BSA, 20mM TRIS-HCl, pH 7.8, 5mM dithiothreitol, 60mM KCl and 1mM EDTA.
SPECIFIC ACTIVITY:
100U/µl. One unit is defined as the amount of enzyme that removes 100fmol O
6
-methylguanine from DNA.
QUALITY CONTROL:
The biological activity has been checked in a radioactive standard MGMT assay.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Do not store at -80°C.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P16455:
MGMT (human)
Further Categories Containing This Product:
DNA & RNA Methyl & Alkyl Transferases / Related Products
•
Recombinant Proteins / Fusion Proteins
ALX-804-657
Revised 11-Jul-07
Monoclonal Antibody to DJ-1 (human) (1B11)
SYNONYMS
anti-PARK7 (human) MAb (1B11)
anti-Parkinson Disease Protein 7 (human) MAb (1B11)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Transcription Regulators Other Products
Ordering Information
Product Numbers:
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ALX-804-657-R100
100 µl
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
1B11
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human DJ-1 (aa 1-189).
SPECIFICITY:
Recognizes human DJ-1.
APPLICATION:
ELISA
Western Blot (1:500-1:2'000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for one month when stored at 4°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
DJ-1 (PARK7) is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signalling and oxidative stress. Mutations in the PARK7 gene are the cause of autosomal recessive early-onset Parkinson’s disease 7 (Park7).
General Literature References
Neurobiology of alpha-synuclein:
K. Vekrellis, et al.; Mol. Neurobiol.
30
, 1 (2004), (Review)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Monoclonal Antibodies
ALX-804-369
Revised 13-Nov-08
Monoclonal Antibody to Dnmt1 (60B1220.1)
SYNONYMS
anti-DNA Methyltransferase-1 MAb (60B1220.1)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA & RNA Methyl & Alkyl Transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-369-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY: