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Forkhead Box [FOX] Proteins / Related Products
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ALX-370-012 Revised 09-Oct-07
20-Hydroxyecdysone
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SYNONYMS β-Ecdysone
2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one
Ecdysterone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-012-M005   5 mg 55.00 USD Add To Cart
ALX-370-012-M010   10 mg 90.00 USD Add To Cart
ALX-370-012-M050   50 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C27H44O7
MW: 480.6
CAS NUMBER: 5289-74-7
MERCK INDEX: 14: 3491
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of Drosophila melanogaster.
Product Specific Literature References
H. Hampshire and D.H.S. Horn; Chem. Commun. 37 (1966)
M.N. Galbraith and D.H.S. Horn; Chem. Commun. 905 (1966)
H. Rimpler and G. Schulz; THL 22, 2033 (1967)
L. Canonica, et al.; Phytochemistry 14, 525 (1975)
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death: C. Cao, et al.; J. Cell Biol. 176, 843 (2007) Abstract
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins / Related Products • Non-apoptotic Cell Death / Necrosis
 
 
ALX-804-708 Revised 30-Jan-07
Monoclonal Antibody to FOXP3 (mouse) (MF333F)
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SYNONYMS anti-Forkhead Box Protein P3 (mouse) MAb (MF333F)
anti-Scurfin (mouse) MAb (MF333F)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Forkhead Box [FOX] Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-708-C050   50 µg 220.00 USD Add To Cart
ALX-804-708-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: MF333F
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY: Recognizes both natural and recombinant mouse FOXP3. Detects a band of ~46-49kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:10’000)
Immunocytochemistry
Immunohistochemistry (frozen sections) (see [3], [4])
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
[1] Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance: E. Ambrosino, et al.; Cancer Res. 66, 7734 (2006) Abstract
[2] Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells: G. Raimondi, et al.; J. Immunol. 176, 2808 (2006) Abstract
[3] Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice: M.J. Perone, et al.; J. Immunol. 177, 5278 (2006) Abstract
[4] "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig: Y.Y. Lan, et al.; J. Immunol. 177, 5868 (2006) Abstract
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3 / Related Products • Monoclonal Antibodies
 
 
ALX-210-436 Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
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SYNONYMS anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Forkhead Box [FOX] Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-436-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY: Recognizes both natural and recombinant mouse FOXP3. Detects a
band of ~46-49kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:5’000-1:10’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3 / Related Products • Polyclonal Antibodies
 
 
ALX-210-420 Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
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SYNONYMS anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Forkhead Box [FOX] Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-420-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse FOXP3 (forkhead box protein P3).
SPECIFICITY: Recognizes both natural and recombinant mouse FOXP3. Detects a band of ~46-49kDa by Western blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:10’000)
Western blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
FOXP3 / Related Products • Polyclonal Antibodies
 
 
ALX-380-243 Revised 08-Apr-08
Siomycin
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SYNONYMS Mutabilycin
Sporangiomycin
Antibiotic 6741-21
Mutabillicin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-243-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C71H81N19O18S5
MW: 1648.9
CAS NUMBER: 12656-09-6
RTECS: VX0600000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4617.
PURITY: ≥95% (HPLC)
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Macrocyclic thiazole antibiotic with potent and selective antibacterial activity. Potent inhibitor of the oncogenic transcription factor forkhead box M1 (FoxM1) that downregulates protein and mRNA levels of FoxM1. Inhibits FoxM1 induced cell growth.

Product Specific Literature References
Studies on siomycin. I. Physicochemical properties of siomycins A, B and C: M. Ebata, et al.; J. Antibiot. 22, 364 (1969)
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1: S.K. Radhakrishnan, et al.; Cancer Res. 22, 364 (2006) Abstract; Full Text
Future roles for FoxM1 inhibitors in cancer treatments: G.R. Adami & H. Ye; Future Oncol. 3, 1 (2007) Abstract; Full Text
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins / Related Products • Other Natural Products - DNA Regulation / Transcription
 
 
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