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ALX-804-099
Revised 17-Jan-07
Monoclonal Antibody to Mineralocorticoid (Aldosterone) Receptor (H10E4C9F)
SYNONYMS
anti-MR (Aldosterone) MAb (H10E4C9F)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aldosterone & Aldosterone Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-099-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Others
CLONE:
H10E4C9F
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Produced using the anti-idiotypic method.
CONCENTRATION:
4mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Aldosterone.
SPECIFICITY:
Recognizes human, rat, rabbit and chicken MR (mineralocorticoid receptor). Detects a band of ~116kDa by Western blot.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections)
: (1:100) Staining is blocked by pre-incubating the sample with aldosterone.
Western Blot
: (1:250) [ECL: Enhanced detection systems like enhanced chemiluminescence are recommended].
Functional Application
: Blocks the binding of aldosterone to the MR.
Note:
Not suitable for immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Internal image properties of a monoclonal auto-anti-idiotypic antibody and its binding to aldosterone receptors:
M. Lombes, et al.; J. Biol. Chem.
264
, 2528 (1989)
Abstract
;
Full Text
Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone:
M. Lombes, et al.; PNAS
87
, 1086 (1990)
Abstract
;
Full Text
Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor:
M. Lombes, et al.; Circ. Res.
71
, 503 (1992)
Abstract
Aldosterone antagonists destabilize the mineralocorticosteroid receptor:
B. Couette, et al.; Biochem. J.
282
, 697 (1992)
Abstract
Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart:
M. Lombes, et al.; Circulation
92
, 175 (1995)
Abstract
;
Full Text
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development:
M. Kingsley-Kallesen, et al.; Mol. Endocrinol.
16
, 2008 (2002)
Abstract
;
Full Text
Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action:
G. Li, et al.; J. Biol. Chem.
278
, 41779 (2003)
Abstract
;
Full Text
Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation:
I. Bossis, et al.; Endocrinology
145
, 3523 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
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