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DNA Regulation / Transcription
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ALX-400-038 Revised 18-Feb-08
Lomustine
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SYNONYMS CCNU
N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (DNA Interaction & Gene Regulation)
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ALX-400-038-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C9H16CIN3O2
MW: 233.7
CAS NUMBER: 13010-47-4
MERCK INDEX: 14: 5564
PURITY: ≥97% (Assay)
APPEARANCE: Yellowish crystalline solid.
SOLUBILITY: Soluble in 100% ethanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: MAY BE CARCINOGENIC. IRRITANT.

Product Description
Possesses antitumor activity similar to carmustine (Prod. No. ALX-400-037).
Related Products
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-340-026 Revised 16-Jun-06
LY-171,883
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SYNONYMS 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-340-026-M010   10 mg 68.00 USD Add To Cart
Product Specification
FORMULA: C16H22N4O3
MW: 318.4
CAS NUMBER: 88107-10-2
PURITY: ≥98%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Organic stock solutions are stable for at least six months when stored at –20°C.

Product Description
Competitive leukotriene D4 (LTD4) antagonist. Has also been shown to bind to the γ-isofom of the peroxisome proliferator activated receptor (PPARγ).
Product Specific Literature References
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5- yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985) Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993) Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid- activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994) Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995) Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
 
 
ALX-201-258 Revised 18-Mar-08
Lysyl Oxidase-like Protein 4 (human) (recombinant) (His)
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SYNONYMS LOXL4 (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Nucleic Acid Oxidation & Alkylation / Related Products
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ALX-201-258-C100   100 µg 390.00 USD Add To Cart
Product Specification
MW: ~65kDa
SOURCE/HOST: Produced in E. coli. Human lysyl oxidase-like protein 4 (LOXL4) (aa 159-756) is fused to a His-tag.
CONCENTRATION: ~0.33mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized from 50mM HEPES, pH 8.0, containing 200mM sodium chloride.
RECONSTITUTION: Reconstitute with 300µl of 10% glycerol containing 2mM β-mercaptoethanol.
SPECIFIC ACTIVITY: 0.02-0.03µmol/min/µg
APPLICATION: In vitro conjugation assays by monitoring benzylamine oxidation at A250mm. Typical concentration to support conjugation in vitro is 0.5-2.5µM depending on conditions.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain: L. Asuncion, et al.; Matrix Biol. 20, 487 (2001) Abstract
Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains: J.M. Maki, et al.; Matrix Biol. 20, 493 (2001) Abstract
Lysyl oxidases: a novel multifunctional amine oxidase family: K. Csiszar; Prog. Nucl. Acid Res. Mol. Biol. 70, 1 (2001) Abstract
Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage: H. Ito, et al.; J. Biol. Chem. 276, 24023 (2001) Abstract; Full Text
A molecular role for lysyl oxidase in breast cancer invasion: D.A. Kirschmann, et al.; Cancer Res. 62, 4478 (2002) Abstract; Full Text
Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies: S.T. Jung, et al.; Protein Expr. Purif. 31, 240 (2003) Abstract
Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4: M.S. Kim, et al.; J. Biol. Chem. 278, 52071 (2003) Abstract; Full Text
Structural and functional diversity of lysyl oxidase and the LOX-like proteins: J. Molnar, et al.; Biochim. Biophys. Acta 1647, 220 (2003) Abstract
Lysyl oxidase is essential for hypoxia-induced metastasis: J.T. Erler, et al.; Nature 440, 1222 (2006) Abstract
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma: T. Gorogh, et al.; J. Pathol. 212, 74 (2007) Abstract
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer: G. Wu, et al; Cancer Res. 67, 4123 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q96JB6: Lysyl Oxidase-like Protein 4 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-297 Revised 06-Dec-04
M344
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SYNONYMS 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)-benzamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY HDAC Inhibitors
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ALX-270-297-M001   1 mg 95.00 USD Add To Cart
ALX-270-297-M005   5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C16H25N3O3
MW: 307.4
CAS NUMBER: 251456-60-7
PURITY: ≥98%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in DMSO (1mg/ml)
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent inhibitor of histone deacetylase (HDAC) (IC50≤1µM).
Product Specific Literature References
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation: M. Jung, et al.; J. Med. Chem. 42, 4669 (1999) Abstract
 
 
ALX-270-344 Revised 05-Feb-05
MC 1293
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SYNONYMS 3-(4-Toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY HDAC Inhibitors
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ALX-270-344-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C16H16N2O3
MW: 284.3
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of histone deacetylase 1 (HDAC1) (IC50 = 4.5µM) [2] and maize histone deacetylase HD2 (IC50=1.9µM) [1].
Product Specific Literature References
[1] 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors: S. Massa, et al.; J. Med. Chem. 44, 2069 (2001) Abstract
[2] Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation: A. Mai, et al.; J. Med. Chem. 45, 1778 (2002) Abstract
 
 
APO-54N-035 Revised 10-Oct-08
MDA5 (human) (IntraCellular) Detection Set [For ELISA Application]
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SYNONYMS Melanoma Differentiation-associated Gene 5 (human) (IntraCellular) Detection Set [For ELISA Application]
Helicard (human) (IntraCellular) Detection Set [For ELISA Application]
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
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APO-54N-035-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0 to 32ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human MDA5 in cell extracts.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description

This intracellular Detection Set is for measuring protein levels in cell lysates.  It allows to quantitatively determine:
a. Levels of MDA5
b. Interferon response since MDA5 is an interferon inducible gene
b. Virus infection response
General Information
The innate immune response to viruses is initiated upon detection of viral RNA generated during the life cycle of most viruses [1]. Recognition of the viral RNA is mediated by either the two cytoplasmic RNA helicases Retinoic acid Inducible Gene-1 (RIG-I ; Ddx58) and Melanoma Differentiation Associated gene 5 (MDA5 / Helicard; Ifih1) [2] or by Toll-like Receptor 3 (TLR3) located to an endosomal-like compartment [3]. RIG-I and MDA5 belongs to the family of RIG-I like receptor (RLR) together with the protein LGP2 whose function is still elusive [4, 5]. Upon binding to RNA, RIG-I or MDA5 binds a new mediator named Cardif, MAVS (mitochondrial antiviral signalling), IPS-1 (interferon-β promoter stimulator 1) or VISA (virus-induced signalling adapter) [6, 7]. Cardif/ MAVS/ IPS-1/ VISA then interacts with several TRAFs molecules, leading to the activation of regulatory kinases, such as TBK1, IKKε , and the IKKα/β/γ complex. These kinases activate respective transcription factors, IRF-3, IRF-7, and NF-κB that participate in the activation of IFN and other inflammatory cytokine genes. RIG-I is activated by dsRNA and 5′-ppp RNA while only poly I: C acts as a chemical agonist for MDA5. The physiological agonist of MDA5 has still to be discovered. Mda-5 is an early response gene inducible by IFN and tumor necrosis factor-α, responding predominantly to IFN-β [8].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9BYX4: MDA5 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[8] mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract; Full Text
[6] Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
[7] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction: T. Kawai, et al.; Nat. Immunol. 6, 981 (2005) Abstract
[1] Recognition of viruses by innate immunity: O. Takeuchi & S. Akira; Immunol. Rev. 220, 214 (2007) Abstract
[4] Cytoplasmic recognition of RNA: M. Yoneyama, et al.; Adv. Drug Deliv. Rev. 60, 841 (2008) Abstract
[5] Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses: T. Venkataraman, et al.; J. Immunol. 178, 6444 (2007) Abstract
[2] MDA5/RIG-I and virus recognition: O. Takeuchi & S. Akira; Curr. Opin. Immunol. 20, 17 (2008) Abstract
[3] TLR3: Interferon induction by double-stranded RNA including poly(I:C): M. Matsumoto & T. Seya; Adv. Drug Deliv. Rev. 60, 805 (2008)
Related Products
Further Categories Containing This Product:
NF-kB Pathway Other Products • Antiviral Signalling / Related Products • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products • ELISA Sets
 
 
APO-54N-039 Revised 10-Oct-08 New product
MDA5 (human) (IntraCellular) ELISA Kit
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SYNONYMS Melanoma Differentiation-associated Gene 5 (human) (IntraCellular) ELISA Kit
Helicard (human) (IntraCellular) ELISA Kit
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases / Related Products
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APO-54N-039-KI01   1 Kit 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0.5 to 32ng/ml).
QUANTITY: For 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human MDA5 in cell extracts.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
NF-kB Pathway Other Products • Antiviral Signalling / Related Products • Caspase Recruitment Domain [CARD] Proteins / Related Products • Interferons & Interferon Receptors Other Products • ELISA & EIA Kits
 
 
ALX-440-045 Revised 17-Jul-07
Methotrexate
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SYNONYMS (+)-Amethopterin
4-Amino-10-methylfolic acid
Methylaminopterin
MTX
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Enzyme Inhibitors)
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ALX-440-045-M050   50 mg 25.00 USD Add To Cart
ALX-440-045-M100   100 mg 45.00 USD Add To Cart
ALX-440-045-M500   500 mg 135.00 USD Add To Cart
ALX-440-045-G001   1 g 240.00 USD Add To Cart
Product Specification
FORMULA: C20H22N8O5
MW: 454.5
CAS NUMBER: 59-05-2
MERCK INDEX: 14: 5985
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.
Product Specific Literature References
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998) Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998) Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998) Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999) Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000) Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • MDR Other Products • Folic Acid & Folate Receptors / Related Products • DNA Replication Inhibitors
 
 
ALX-270-450 Revised 08-Jan-07
3-Methyl-5-AIQ . hydrochloride
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SYNONYMS 3-Methyl-5-aminoisoquinolinone . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-450-M001   1 mg 50.00 USD Add To Cart
ALX-270-450-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C10H10N2O . HCl
MW: 174.2 . 36.4
PURITY: ≥98% (NMR)
APPEARANCE: Light brown solid.
SOLUBILITY: Soluble in water or DMSO; poorly soluble in 100% ethanol or methanol; insoluble in dichloromethane or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
IDENTITY: Identity determined by IR, 1H-NMR, 13C-NMR.

Product Description
Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=0.23µM) in vitro. Exhibits outstanding therapeutic benefits in models of myocardial infarction, ischaemia-reperfusion of the liver and kidney, heart transplantation and acute lung inflammation.
Product Specific L