Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
DNA Regulation / Transcription
> Parkinson's Disease Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items 10 of 10
ALX-270-484
Revised 07-Apr-08
AGK2
SYNONYMS
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-484-M001
1 mg
40.00 USD
ALX-270-484-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
23
H
13
Cl
2
N
3
O
2
MW:
434.3
CAS NUMBER:
304896-28-4
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC
50
=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Specific Literature References
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease:
T.F. Outeiro, et al.; Science
317
, 516 (2007)
Abstract
Related Products
ALX-270-485
B2
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-270-485
Revised 07-Apr-08
B2
SYNONYMS
CPNQ
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-485-MC05
0.5 mg
90.00 USD
Product Specification
FORMULA:
C
20
H
17
ClN
4
O
3
MW:
396.8
CAS NUMBER:
115687-05-3
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and oxygen.
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC
50
=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Product Specific Literature References
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases:
R.A. Bodner, et al.; PNAS
103
, 4246 (2006)
Abstract
;
Full Text
Related Products
ALX-270-484
AGK2
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-522-135
Revised 05-May-08
CDNF (human) (recombinant)
SYNONYMS
Conserved Dopamine Neurotrophic Factor (human) (recombinant)
ARMEL (human) (recombinant)
ARMET-like Protein 1 Precursor (human) (recombinant)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Neurotrophic Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-135-C010
10 µg
390.00 USD
Product Specification
MW:
~16kDa
SOURCE/HOST:
Produced in
E. coli
. Human CDNF (conserved dopamine neurotrophic factor) (aa 27-187).
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Human CDNF encodes a 187 amino acid protein with predicted signal peptides. In mouse, it is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q49AH0:
CDNF (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo:
P. Lindholm, et al.; Nature
448
, 73 (2007)
Abstract
Related Products
ALX-210-960
Polyclonal Antibody to CDNF (mouse) (AT134)
ALX-522-133
CDNF (mouse) (recombinant)
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-522-133
Revised 31-Mar-08
CDNF (mouse) (recombinant)
SYNONYMS
Conserved Dopamine Neurotrophic Factor (mouse) (recombinant)
ARMEL (mouse) (recombinant)
ARMET-like Protein 1 Precursor (mouse) (recombinant)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Neurotrophic Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-133-C010
10 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW:
~16kDa
SOURCE/HOST:
Produced in
E. coli
. Untagged mouse CDNF (aa 27-187).
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Mouse CDNF encodes a 187 amino acid protein with predicted signal peptides. It is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q8CC36:
CDNF (mouse)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.:
P. Lindholm, et al.; Nature
448
, 73 (2007)
Abstract
Related Products
ALX-210-960
Polyclonal Antibody to CDNF (mouse) (AT134)
ALX-522-135
CDNF (human) (recombinant)
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-550-400
Revised 16-Jan-06
Dimethyl-W84 dibromide
SYNONYMS
N,N’-Bis[3-(1,3-dihydro-5-methyl-1,3-dioxo-2
H
-isoindol-2-yl)propyl]-N,N,N’,N’-tetramethyl-1,6-hexanediamminium dibromide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Acetylcholine Receptors (Muscarinic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-400-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
34
H
48
Br
2
N
4
O
4
MW:
736.6
CAS NUMBER:
402475-33-6
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, water or aqueous buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles.
Product Description
Very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine. Affinity for the free receptor is about 10-fold higher than with W84 (Prod. No.
ALX-550-399
). p
K
A
=7.08, p(α
K
A
)=6.75, pEC
50,diss
=6.77.
Product Specific Literature References
Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors:
C. Trankle, et al.; Mol. Pharmacol.
54
, 139 (1998)
Abstract
;
Full Text
Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors:
C. Trankle, et al.; Mol. Pharmacol.
56
, 962 (1999)
Abstract
;
Full Text
Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties:
R. Li, et al.; Arch. Pharm.
334
, 121 (2001)
Abstract
Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators:
A. Raasch, et al.; J. Med. Chem.
45
, 3809 (2002)
Abstract
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors:
C. Trankle, et al.; Mol. Pharmacol.
64
, 180 (2003)
Abstract
;
Full Text
Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupie:
U. Voigtlander, et al.; Mol. Pharmacol.
64
, 21 (2003)
Abstract
;
Full Text
Contribution of lateral substituents in symmetrical and non-symmetrical heptane-bisammonio compounds to the allosteric stabilization of N-methylscopolamine binding to muscarinic M2 receptors:
M. Staudt, et al.; Arch. Pharm. (Weinheim)
336
, 385 (2003)
Abstract
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors:
C. Trankle, et al.; Mol. Pharmacol.
68
, 1597 (2005)
Abstract
General Literature References
G protein-coupled receptor allosterism and complexing:
A. Christopoulos and T. Kenakin; Pharmacol. Rev.
54
, 323 (2002)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-804-657
Revised 11-Jul-07
Monoclonal Antibody to DJ-1 (human) (1B11)
SYNONYMS
anti-PARK7 (human) MAb (1B11)
anti-Parkinson Disease Protein 7 (human) MAb (1B11)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Transcription Regulators Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-657-R100
100 µl
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
1B11
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human DJ-1 (aa 1-189).
SPECIFICITY:
Recognizes human DJ-1.
APPLICATION:
ELISA
Western Blot (1:500-1:2'000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for one month when stored at 4°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
DJ-1 (PARK7) is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signalling and oxidative stress. Mutations in the PARK7 gene are the cause of autosomal recessive early-onset Parkinson’s disease 7 (Park7).
General Literature References
Neurobiology of alpha-synuclein:
K. Vekrellis, et al.; Mol. Neurobiol.
30
, 1 (2004), (Review)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Monoclonal Antibodies
ALX-550-401
Revised 16-Jan-06
Naphmethonium dibromide
SYNONYMS
N-[3-(1,3-Dihydro-1,3-dioxo-2
H
-isoindol-2-yl)propyl]-N’-[3-(1,3-dioxo-1
H
-benz[d,e]isoquinolin-2(3
H
)-yl)-2,2-dimethylpropyl]-N,N,N’,N’-tetramethyl-1,6-hexanediamminium dibromide
2-{3-[1-(6-{1,1-Dimethyl-1-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propyl]ammonium}hexyl)-1,1-dimethylammonio]-2,2-dimethylpropyl}benzo[d,e]isoquinoline-1,3-dione dibromide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Acetylcholine Receptors (Muscarinic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-401-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
38
H
50
Br
2
N
4
O
4
MW:
786.6
CAS NUMBER:
505059-27-8
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, water or aqueous buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
Product Description
Very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine and exhibits positive cooperativity, i.e. shows higher affinity for occupied receptors compared to free receptors. Affinity for the free receptor is about 100-fold higher than with W84 (Prod. No.
ALX-550-399
). p
K
A
=8.29, p(α
K
A
)=8.66, pEC
50,diss
=8.36.
Product Specific Literature References
Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding:
M. Muth, et al.; J. Med. Chem.
46
, 1031 (2003)
Abstract
Design, Synthesis, and Action of Oxotremorine-Related Hybrid-Type Allosteric Modulators of Muscarinic Acetylcholine Receptors:
T. Disingrini, et al.; J. Med. Chem.
49
, 366 (2006)
Abstract
General Literature References
G protein-coupled receptor allosterism and complexing:
A. Christopoulos and T. Kenakin; Pharmacol. Rev.
54
, 323 (2002)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-210-928
Revised 08-Nov-07
Polyclonal Antibody to LRRK2 (human) (AT106)
SYNONYMS
anti-Leucine-rich Repeat Kinase 2 (human) PAb (AT106)
anti-RIP7 (human) PAb (AT106)
anti-PARK8 (human) PAb (AT106)
anti-Dardarin (human) PAb (AT106)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
RIP Kinases
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-928-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human LRRK2 (leucine-rich repeat kinase 2) (aa 1838-2133).
SPECIFICITY:
Recognizes human LRRK2. The strongest recognized epitope is PDQPRLTIPISQ (aa 1843-1854) as defined by epitope mapping.
APPLICATION:
Immunohistochemistry (paraffin sections (1:500))
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
LRRK2 in Parkinson’s disease and dementia with Lewy bodies:
X. Zhu, et al.; Mol. Neurodegener.
1
, 17 (2006)
Abstract
;
Full Text
General Information
LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease:
C. Paisan-Ruiz, et al.; Neuron
44
, 595 (2004)
Abstract
From The Cover: Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity:
A.B. West, et al.; PNAS
102
, 16842 (2005)
Abstract
The RIP kinases: crucial integrators of cellular stress:
E. Meylan and J. Tschopp; TIBS
30
, 151 (2005)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Polyclonal Antibodies
ALX-210-960
Revised 16-Oct-08
Polyclonal Antibody to CDNF (mouse) (AT134)
SYNONYMS
anti-Conserved Dopamine Neurotrophic Factor (mouse) PAb (AT134)
anti-ARMEL (mouse) PAb (AT134)
anti-ARMET-like Protein 1 Precursor (mouse) PAb (AT134)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Neurotrophic Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-960-C100
100 µg
370.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CDNF (aa 27-187)
SPECIFICITY:
Recognizes mouse CDNF.
APPLICATION:
Western blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Mouse CDNF encodes a 187 amino acid protein with predicted signal peptides. It is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-135
CDNF (human) (recombinant)
ALX-522-133
CDNF (mouse) (recombinant)
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Polyclonal Antibodies
ALX-550-399
Revised 16-Jan-06
W84 dibromide
SYNONYMS
N,N’-Bis[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]-N,N,N’,N’-tetramethyl-1,6-hexanediamminium dibromide
Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium] dibromide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Acetylcholine Receptors (Muscarinic) / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price
