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Antithrombotic Agents/Related Products
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ALX-430-115 Revised 14-Aug-08
Aspirin
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SYNONYMS Acetylsalicylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-115-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C9H8O4
MW: 180.2
CAS NUMBER: 50-78-2
MERCK INDEX: 14: 851
RTECS: VO0700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 2 years when stored at room temperature. Keep aqueous solutions on ice and use within 30 minutes. Unstable in basic solutions pH>7.4.
HAZARD: HARMFUL.

Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin: E. Kopp & S. Ghosh; Science 265, 956 (1994) Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation: M. Grilli, et al.; Science 274, 1383 (1996) Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta: M.J. Yin, et al.; Nature 396, 77 (1998) Abstract
The pleiotropic functions of aspirin: mechanisms of action: A.R. Amin, et al.; Cell Mol. Life Sci. 56, 305 (1999) Abstract
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors • Antithrombotic Agents/Related Products
 
 
ALX-350-226 Revised 07-Apr-08
Caffeic acid methyl ester
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SYNONYMS Methyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-226-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H10O4
MW: 194.2
CAS NUMBER: 3843-74-1
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Slightly yellowish solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Inhibitor of ornithine decarboxylase and protein tyrosine kinases. Has a strong inhibitory effect on human platelet aggregation. Shows antioxidant, antiproliferative and cytotoxic properties.
Product Specific Literature References
Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth: C.V. Rao, et al.; Chem. Biol. Interactions 84, 277 (1992) Abstract
Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb: W.C. Chang & F.L. Hsu; Prostaglandins Leukot. Essent. Fatty Acids 45, 307 (1992) Abstract
Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell: I.R. Lee & M.Y. Yang; Arch. Pharm. Res. 17, 476 (1994) Abstract
Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata: M.K. Pyo, et al.; Arch. Pharm. Res. 25, 325 (2002) Abstract
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles: J.E. Burdette, et al.; J. Agric. Food Chem. 50, 7022 (2002) Abstract
Phenolic acid derivatives with potential anticancer properties--a structure-activity relationship study. Part 1: methyl, propyl and octyl esters of caffeic and gallic acids: S.M. Fiuza, et al.; Bioorg. Med. Chem. 12, 3581 (2004) Abstract
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Tyrosine Kinase Inhibitors • Antitumor Agents (Anti-proliferative) • Antithrombotic Agents/Related Products • Natural Products - Antioxidants
 
 
ALX-350-124 Revised 05-Apr-08
Ferulenol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-124-M001   1 mg 45.00 USD Add To Cart
ALX-350-124-M005   5 mg 135.00 USD Add To Cart
ALX-350-124-M010   10 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C24H30O3
MW: 366.5
CAS NUMBER: 6805-34-1
SOURCE/HOST: Isolated from Ferula communis.
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.
Product Specific Literature References
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract
Further Categories Containing This Product:
Taxol/Related Products • Antithrombotic Agents/Related Products • Microtubule Modulators • Natural Products - Antitumor Reagents • Natural Products for Cell Cycle Research
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
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SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation/Transcription • Antitumor Agents (Anti-proliferative) • Antithrombotic Agents/Related Products • MMP Inhibitors • Flavonoids/Related Products • Natural Products - Antifungal Agents • Epstein Barr Virus/Related Products
 
 
ALX-350-352 Revised 06-Mar-08
Magnolol
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SYNONYMS 5,5’-Diallyl-2,2’-biphenyldiol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
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ALX-350-352-M005   5 mg 55.00 USD Add To Cart
ALX-350-352-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 528-43-8
MERCK INDEX: 14: 5697
RTECS: DV5105500
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003) Abstract
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • Anxiolytic Agents/Related Products • Antithrombotic Agents/Related Products • Natural Products with Antibiotic Activity • Natural Products - Antitumor Reagents • Natural Products for Neurological Research
 
 
ALX-380-234 Revised 08-Apr-08
Pimprinine
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SYNONYMS 5-(3-Indolyl)-2-methyloxazole
Antibiotic WS 30581C
Antibiotic APHE 3
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-380-234-M001   1 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C12H10N2O
MW: 198.2
CAS NUMBER: 13640-26-1
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5360.
PURITY: ≥95% (HPLC)
APPEARANCE: Tan powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent inhibitor of monoamine oxidase. Has antiepileptic affects. Inhibits platelet aggregation.
Product Specific Literature References
The structure and synthesis of pimprinine: B.S. Joshi, et al.; Tetrahedron 19, 1437 (1963) Abstract
Studies on new antiplatelet agents, WS-30581 A and B: K. Umehare, et al.; J. Antibiot. (Tokyo) 37, 1153 (1984) Abstract
Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity: S.R. Naik, et al.; J. Biotechnol. 88, 1 (2001) Abstract
Further Categories Containing This Product:
Antithrombotic Agents/Related Products • Alkaloids
 
 
ALX-350-114 Revised 03-Dec-07
Polydatin
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SYNONYMS Piceid
Resveratrol-3β-mono-D-glucoside
3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-β-D-glucoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-114-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H22O8
MW: 390.4
CAS NUMBER: 65914-17-2
SOURCE/HOST: Isolated from Polygonum cuspidatum.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in ethyl acetate, DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL. IRRITANT.

Product Description
Platelet aggregation inhibitor. Shows multiple effects on vascular smooth muscle cells, myocardial cells, endothelial cells and white blood cells after shock. May inhibit phospholipase A2. Inhibits the expression of various cell adhesion molecules.
Product Specific Literature References
Wine as a biological fluid: history, production, and role in disease prevention: G.J. Soleas, et al.; J. Clin. Lab. Anal. 11, 287 (1997) Abstract
Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes: Z.S. Huang, et al.; World J. Gastroenterol. 5, 41 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
The mechanism of Polydatin in shock treatment: K.S. Zhao, et al.; Clin. Hemorheol. Microcirc. 29, 211 (2003) Abstract
Effect of polydatin on phospholipase A2 in lung tissues in rats with endotoxic shock: S.Y. Shu, et al.; Chin. J. Traumatol. 7, 239 (2004) Abstract
Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury: Y. Cheng, et al.; Brain Res. 1110, 193 (2006) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Antithrombotic Agents/Related Products • COX Inhibitors • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3]/Related Products • Natural Products - Chemopreventive Agents
 
 
ALX-385-030 Revised 06-Mar-08 New product
Trihydroxyethylrutin
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SYNONYMS Troxerutin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-030-G005   5 g 30.00 USD Add To Cart
ALX-385-030-G025   25 g 90.00 USD Add To Cart
Product Specification
FORMULA: C33H42O19
MW: 742.7
CAS NUMBER: 7085-55-4
MERCK INDEX: 14: 9789
RTECS: LK8331500
SOURCE/HOST: Isolated from Sophora japonica L.
PURITY: ≥95% (Assay)
APPEARANCE: Light yellow to greenish powder.
SOLUBILITY: Soluble in water, glycerol or propylene glycol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Flavonoid derivative. Vaso- and cardioprotective agent used clinically to treat venous disorders. Inhibits platelet aggregation. Protects biomembranes and DNA against the deleterious effects of γ-radiation. Free radical scavenger. Antioxidant.
Product Specific Literature References
Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro: J. Swies, et al.; Pol. J. Pharmacol. Pharm. 36, 455 (1984) Abstract
Effect of troxerutin and methionine on spin trapping of free oxy-radicals: I.E. Blasig, et al.; Biomed. Biochim. Acta 47, S252 (1988) Abstract
Free radical scavenging and skin penetration of troxerutin and vitamin derivatives: M. Kessler, et al.; J. Dermatolog. Treat. 13, 133 (2002) Abstract
Radioprotection of normal tissues in tumor-bearing mice by troxerutin: D.K. Maurya, et al.; J. Radiat. Res. 45, 221 (2004) Abstract; Full Text
Protection of cellular DNA from gamma-radiation-induced damages and enhancement in DNA repair by troxerutin: D.K. Maurya, et al.; Mol. Cell. Biochem. 280, 57 (2005) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Antithrombotic Agents/Related Products
 
 
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