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NAALADase / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > NAALADase / Related Products
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ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related ProductsNAALADase / Related ProductsPeptides
 
 
ALX-550-380 Revised 06-Feb-05
PBDA
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SYNONYMS 4,4'-Phosphonicobis(butane-1,3-dicarboxylic acid)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NAALADase / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-380-M001   1 mg 55.00 USD Add To Cart
ALX-550-380-M005   5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C12H19O10P
MW: 354.3
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase) and an mGluR3-selective agonist.
Further Categories Containing This Product:
Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-358 Revised 06-Feb-05
2-(Phosphonomethyl)-pentanedioic acid
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SYNONYMS PMPA
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NAALADase / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-358-M001   1 mg 50.00 USD Add To Cart
ALX-550-358-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C6H11O7P
MW: 226.1
PURITY: ≥97%
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase (NAALADase), which is a membrane-bound peptidase that hydrolyses N-acetyl-L-aspartate-L-glutamate (NAAG) (Prod. No. ALX-151-020), a major brain peptide.
Product Specific Literature References
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II: R. Luthi-Carter, et al.; Brain Res. 795, 341 (1998) Abstract
 
 
ALX-550-525 Revised 13-Sep-07
ZJ-43
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY NAALADase / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-525-M002   2 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H20N2O7
MW: 304.3
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, methanol, 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Potent inhibitor of N- acetylaspartylglutamate (NAAG) peptidases, glutamate carboxypeptidase II (NAALADase I) (Ki=0.8nm) and glutamate carboxypeptidase III  (NAALADase II) (Ki=23nm). Group II metabotropic glutamate receptor (mGluR) agonist.
Product Specific Literature References
NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR: R.T. Olszewski, et al.; J. Neurochem. 89, 876 (2004) Abstract
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat: C. Zhong, et al.; J. Neurochem. 97, 1015 (2006) Abstract
Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats: T. Yamamoto, et al.; Eur. J. Neurosci. 25, 147 (2007) Abstract
 
 

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