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ALX-260-042
Revised 02-Oct-07
Ac-IETD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-042-M001
1 mg
42.00 USD
ALX-260-042-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
31
H
41
N
5
O
12
MW:
675.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
:
N.A. Maianski, et al.; J. Immunol.
172
, 7024 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-043
Revised 13-Nov-06
Ac-IETD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-043-M001
1 mg
62.00 USD
ALX-260-043-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-CHO
FORMULA:
C
21
H
34
N
4
O
10
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-045
Revised 25-Nov-08
Ac-IETD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-045-M001
1 mg
22.00 USD
ALX-260-045-M005
5 mg
83.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
27
H
38
N
6
O
12
MW:
638.6
PEPTIDE CONTENT:
70-90%
PURITY:
98% (HPLC)
APPEARANCE:
White to yellow powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells:
S.H. Kwon, et al.; J. Biol. Chem.
277
, 2073 (2002)
Abstract
;
Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes:
C.A. Belmokhtar, et al.; J. Biol. Chem.
278
, 29571 (2003)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-160
Revised 01-Oct-07
Ac-LDESD-CHO
SYNONYMS
Caspase-2 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-160-M001
1 mg
50.00 USD
ALX-260-160-M005
5 mg
200.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Asp-Glu-Ser-Asp-CHO
FORMULA:
C
24
H
37
N
5
O
13
MW:
603.6
PEPTIDE CONTENT:
70-95%
PURITY:
≥95% (HPLC)
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Reversible inhibitor of caspase-2.
Product Specific Literature References
Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis:
E. Swanton, et al.; J. Biol. Chem.
274
, 37583 (1999)
Abstract
ALX-260-116
Revised 10-Sep-08
Ac-LEHD-AFC
SYNONYMS
Caspase-9 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-116-M005
5 mg
157.00 USD
ALX-260-116-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
33
H
38
F
3
N
7
O
11
MW:
765.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic substrate for caspase-9.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-080
Revised 11-Dec-07
Ac-LEHD-AMC
SYNONYMS
Caspase-9 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-080-M001
1 mg
42.00 USD
ALX-260-080-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
33
H
41
N
7
O
11
MW:
711.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or phosphate buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-9.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
:
N.A. Maianski, et al.; J. Immunol.
172
, 7024 (2004)
Abstract
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells
:
J. Hofmanova; Eur. J. Nutrition
44
, 40 (2005)
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-079
Revised 13-Nov-06
Ac-LEHD-CHO
SYNONYMS
Caspase-9 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-079-M001
1 mg
62.00 USD
ALX-260-079-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-His-Asp-CHO
FORMULA:
C
23
H
34
N
6
O
9
MW:
538.6
PEPTIDE CONTENT:
75-95%
PURITY:
≥95%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Further dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only amount needed at a time to avoid decomposition in solution.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-9.
ALX-260-081
Revised 02-Oct-07
Ac-LEHD-pNA
SYNONYMS
Caspase-9 Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-081-M001
1 mg
32.00 USD
ALX-260-081-M005
5 mg
123.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-His-Asp-pNA (pNA = p-Nitroaniline)
FORMULA:
C
29
H
38
N
8
O
11
MW:
674.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥99% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Chromogenic substrate for caspase-9.
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
ALX-260-118
Revised 05-Apr-05
Ac-LETD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-118-M005
5 mg
157.00 USD
ALX-260-118-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
31
H
38
F
3
N
5
O
12
MW:
729.7
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
20mM stock solution in DMSO is stable at -20°C for 6-8 months. When taking out of the freezer wait until it warms up to room temperature, then open it.
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-084
Revised 24-Feb-05
Ac-LEVD-AFC
SYNONYMS
Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-084-M001
1 mg
32.00 USD
ALX-260-084-M005
5 mg
123.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-Val-Asp-AFC (AFC=7-Amido-4-trifluoromethylcoumarin)
FORMULA:
C
32
H
40
F
3
N
5
O
11
MW:
727.7
PEPTIDE CONTENT:
75-95%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5-8.0.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dissolve only as much as needed at one time because of the possibility of decomposition in solution. Store solution at -20°C. Protect from condensation: when taking the sample out of the container, wait until it warms up to room temperature, then open it.
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-4. Similar to the fluorogenic substrate Ac-LEVD-AMC (Prod. No.
ALX-260-083
); the AFC fluorophore is more sensitive.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-083
Revised 17-Jan-06
Ac-LEVD-AMC
SYNONYMS
Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-083-M001
1 mg
42.00 USD
ALX-260-083-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Glu-Val-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
32
H
43
N
5
O
11
MW:
673.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer, pH 7.5. <
