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ALX-803-011
Revised 11-Nov-05
Monoclonal Antibody to Progesterone Receptor (chicken) (αPR22)
SYNONYMS
anti-PR (chicken) MAb (αPR22)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Progesterone & Progesterone Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-011-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE:
αPR22
ISOTYPE:
Mouse IgG2b
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute in PBS.
IMMUNOGEN:
Purified chicken PR (progesterone receptor).
SPECIFICITY:
Recognizes chicken PR. Does not cross-react with chicken ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION:
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
ALX-803-043
Revised 11-Nov-05
Monoclonal Antibody to Progesterone Receptor (human) (phosphorylated) (pSer190) (1154)
SYNONYMS
anti-PR (human) (phosphorylated) (pSer
190
) MAb (1154)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Progesterone & Progesterone Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-043-C200
200 µg
420.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
1154
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 184-196 of human PR (progesterone receptor) phosphorylated at Ser
190
.
SPECIFICITY:
Recognizes phosphorylated human PR. Detects bands of ~115kDa (B-isoform) and ~90kDa (A-isoform) by Western blot.
APPLICATION:
Immunoprecipitation (10µg per sample)
Western Blot (4µg/ml)
Supershift (EMSA)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody:
D.L. Clemm, et al.; Mol. Endocrinol.
14
, 52 (2000)
Abstract
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
•
Tumor Markers
ALX-803-044
Revised 13-Jul-05
Monoclonal Antibody to Progesterone Receptor (human) (phosphorylated) (pSer294) (608)
SYNONYMS
anti-PR (human) (phosphorylated) (pSer
294
) MAb (608)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Progesterone & Progesterone Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-044-C200
200 µg
420.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
608
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic phosphopeptide corresponding to aa 287-300 of pSer
294
human PR (progesterone receptor).
SPECIFICITY:
Recognizes phosphorylated human PR. Detects a band of ~115kDa (B-isoform) by Western blot.
APPLICATION:
Immunoprecipitation (10µg/sample)
Western Blot (10µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody:
D.L. Clemm, et al.; Mol. Endocrinol.
14
, 52 (2000)
Abstract
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Monoclonal Antibodies
•
Tumor Markers
ALX-803-007
Revised 09-Feb-07
Monoclonal Antibody to Progesterone Receptor (PR-AT 4.14)
SYNONYMS
anti-PR MAb (PR-AT 4.14)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Progesterone & Progesterone Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-007-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE:
PR-AT 4.14
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 533-547(G
533
LPQVYPPYLNYLRP
547
) of N-terminal human PR (progesterone receptor) DNA binding domain.
SPECIFICITY:
Recognizes both the A and B forms of human, mouse, rat, bovine, rabbit and monkey PR. Detects bands of 94kDa (A form) and 120kDa (B form) by Western blot. Does not cross-react with AR (androgen receptor), ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION:
Immunohistochemistry (frozen sections, paraffin sections (5µg/ml)
Immunoprecipitation
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-027
.
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
ALX-801-091
Revised 29-Sep-08
Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PC10)
SYNONYMS
anti-PCNA MAb (PC10)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Proliferating Cell Nuclear Antigen [PCNA] / Related Products
Ordering Information
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Format:
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ALX-801-091-L001
1 ml
480.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
Others
CLONE:
PC10
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. In 0.01M PBS containing 0.1% sodium azide and 1% BSA.
IMMUNOGEN:
Recombinant rat PCNA (proliferating cell nuclear antigen).
SPECIFICITY:
Recognizes PCNA from all vertebrate species, insects and
S. pombe.
Intense nuclear staining of proliferating cells in normal and tumor tissues.
APPLICATION:
Immunohistochemistry (paraffin sections):
Can be used for formalin-fixed, paraffin-embedded tissues. Pretreatment is not required. Recommended dilution is ≥1:40 for biotin based detection. For optimal staining, incubate 20-60 min. at room temperature.
Optimal conditions must be determined individually.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
Proliferating Cell Nuclear Antigen (PCNA) is associated with the DNA replication fork and its major function is described as a processivity factor for replicative DNA polymerases (polymerases δ and ε ) acting as a sliding clamp. It has a highly conserved amino acid sequence and has been identified in all eukaryotes and is being used as a proliferating marker. PCNA is also able to interact with multiple partners involved in Okazaki fragment joining, DNA repair, DNA methylation and chromatin assembly. In DNA repair PCNA has been reported not only for nucleotide excision repair (NER) (in concert with XPG and ERCC1), but also for base excision repair (BER) (binding to uracil-DNA glycosylase) and mismatch repair (MMR) (binding to mismatch repair enzymes MSH2 & MLH1). It is further associated with cell cycle control through cdk-cyclins during G1 to S phase.
Further Categories Containing This Product:
Monoclonal Antibodies
•
Tumor Markers
ALX-804-816
Revised 08-Jan-07
Monoclonal Antibody to Promyelocytic Leukemia Protein (mouse) (36-1-104)
SYNONYMS
anti-PML (mouse) MAb (36-1-104)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Transcription Factors Other Products
Ordering Information
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Format:
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Unit Price:
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ALX-804-816-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
36-1-104
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse PML (promyelocytic leukemia protein) (aa 1-581).
SPECIFICITY:
Recognizes mouse PML. Does not cross-react with human PML. Detects endogenous protein by ICC, IP and WB.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:500-1:1'000)
Functional Application: Electrophoretic Mobility Shift Assay (EMSA).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt if stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
PML is a direct p53 target that modulates p53 effector functions
:
E. de Stanchina, et al.; Mol. Cell
13
, 523 (2004)
Abstract
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
:
R. Bernardi, et al.; Nat. Cell Biol.
6
, 665 (2004)
Abstract
Identification of a tumour suppressor network opposing nuclear Akt function:
L.C. Trotman, et al.; Nature
441
, 523 (2006)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
PML is induced by oncogenic ras and promotes premature senescence
:
G. Ferbeyre, et al.; Genes Dev.
14
, 2015 (2000)
Abstract
The role of PML in tumor suppression
:
P. Salomoni and P.P. Pandolfi; Cell
108
, 165 (2002)
Abstract
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
:
R. Bernardi, et al.; Nat. Cell Biol.
6
, 665 (2004)
Abstract
PML nuclear bodies and apoptosis
:
Y. Takahashi, et al.; Oncogene
23
, 2819 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-229
Revised 11-Jan-07
Monoclonal Antibody to Rad9 (human) (93A535)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
DNA Damage Checkpoint Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-229-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
93A535
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Rad9.
SPECIFICITY:
Recognizes human Rad9. Detects a band of ~50kDa by Western blot.
APPLICATION:
Immunocytochemistry (see [7])
Immunoprecipitation
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage:
R.H. Schiestl, et al.; Mol. Cell. Biol.
9
, 1882 (1989)
Abstract
[2]
Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage:
T.A. Weinert & L.H. Hartwell; Mol. Cell. Biol.
10
, 6554 (1990)
Abstract
[3]
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene:
H.B. Lieberman, et al.; PNAS
93
, 13890 (1996)
Abstract
[4]
MEC1-dependent phosphorylation of Rad9p in response to DNA damage:
A. Emili; Mol. Cell
2
, 183 (1998)
Abstract
[5]
Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex:
E. Volkmer & L.M. Karnitz; J. Biol. Chem.
274
, 567 (1999)
Abstract
;
Full Text
[6]
The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1:
R.P. St. Onge, et al.; Mol. Biol. Cell
10
, 1985 (1999)
Abstract
[7]
Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-x L and promotes apoptosis:
K. Komatsu, et al.; Nature Cell Biol.
2
, 1 (2000)
Abstract
General Information
Rad9 is a cell cycle checkpoint protein: DNA damage leads to extensive phosphorylation of Rad9 [4] which then inhibits progression from G2 in order to preserve cell viability, allowing proper ligation of DNA breaks before the entry of cells into mitosis [1,2]. The human homolog [3] of S. pombe Rad9 is physically proximal to the upstream (DNA damage) signal and associates with two other checkpoint control proteins, Rad1 and HHUS1 [5,6]. Rad9 also interacts with Bcl-2 family proteins Bcl-2 and Bcl-XL, but not with BAX or BAD. Overexpression of Rad9 in mammalian cells leads to apoptosis, where as antisense Rad9 RNA suppresses cell death induced by methyl methanesulphonate [7].
Further Categories Containing This Product:
DNA Replication Other Products
•
Monoclonal Antibodies
ALX-804-442
Revised 04-Aug-08
Monoclonal Antibody to Retinoic Acid Receptor α (human) (763)
SYNONYMS
anti-RARα MAb (763)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Retinoic Acid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-442-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
763
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.4, containing 0.2% BSA and 15mM sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 10-25 of human RARα (retinoic acid receptor-α).
SPECIFICITY:
Recognizes human RARα. Detects a band of ~60kDa by Western blot. Does not cross-react with human RARβ, RARγ or human retinoid X receptor (RXR).
APPLICATION:
Immunohistochemistry (formalin-fixed frozen sections, paraffin sections)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-102
Revised 05-Jun-08
Monoclonal Antibody to Retinoic Acid Receptor α (Rα10)
SYNONYMS
anti-RARα MAb (Rα
10)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Retinoic Acid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-102-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
CLONE:
Rα10
ISOTYPE:
Mouse IgG1
FORMULATION:
Lyophilized from ascites containing 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 444-462 (C
444
SPSLSPSSHRSSPATQSP
462
) of mouse RARα (retinoic acid receptor α).
SPECIFICITY:
Recognizes human, mouse, rat and monkey RARα. Detects a band of ~45kDa by Western blot. Does not cross-react with RARβ or RARγ.
APPLICATION:
Immunoprecipitation
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-166-003
.
General Information
BACKGROUND/TECHNICAL INFORMATION
Due to the extremely low levels of RAR expressed in native tissues, it is recommended that sensitive detection systems, such as enhanced chemiluminescence, are used.
The apparent molecular weight of RARα from transfected COS cells is ~45kDa. In rat tissues, such as skin and testis, doublets in the ~50kDa area are seen. RARα has been identified with this antibody in human dermal and neonatal fibroblast cell lines, as well as mouse F9 and human SH-SY5Y cells; however, RARα from human leukocytes and HUT102 cells were not identified by Prod. No.
ALX-804-102
suggesting that there may be structural variation of RARα between some cell types.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-443
Revised 09-Nov-04
Monoclonal Antibody to Retinoic Acid Receptor β (human) (336)
SYNONYMS
anti-RARβ (human) MAb (336)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Retinoic Acid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-443-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
336
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G pruified antibody in PBS, pH 7.4, containing 0.2% BSA and 15mM sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-25 of human RARβ (retinoic acid receptor β).
SPECIFICITY:
Recognizes human RARβ. Detects a band of ~60kDa by Western blot. Does not cross-react with human RARα, RARγ or human retinoid X receptor (RXR).
APPLICATION:
Immunohistochemistry (formalin-fixed frozen sections, paraffin sections)
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-103
Revised 13-Dec-04
Monoclonal Antibody to Retinoic Acid Receptor β (Rβ28)
SYNONYMS
anti-RARβ MAb (Rβ28)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Retinoic Acid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-103-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
