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Cyclic Nucleotides
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ALX-480-045 Revised 23-Jan-08
N6,O2’-Dibutyryladenosine 3’,5’-cyclic Monophosphate . sodium salt
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SYNONYMS Dibutyryl-cAMP . Na
cAMP, DB-, . Na
Bucladesine . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-045-M005   5 mg 25.00 USD Add To Cart
ALX-480-045-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C18H23N5O8P . Na
MW: 468.4 . 23.0
CAS NUMBER: 16980-89-5
PURITY: ≥97%
APPEARANCE: White lyophilized solid.
SOLUBILITY: Soluble in water (200mM), DMSO (200mM) or 96% ethanol (25mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.

Product Description
Membrane permeable activator of cAMP-dependent protein kinase (cAMP agonist). The product releases butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects.
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
The preparation of acylated derivatives of cyclic nucleotides: T. Posternak & G. Weimann; Meth. Enzymol. 38, 399 (1974) Abstract
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei, et al.; Mol. Pharmacol. 39, 233 (1991) Abstract
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'- monophosphate: A. Hinko and M.S. Soloff; Endocrinology 132, 126 (1993) Abstract
Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E1 in HTLV-I-infected T cells: K. Ikeda, et al.; J. Biol. Chem. 268, 1174 (1993) Abstract; Full Text
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non- transformed rat vascular smooth muscle cells: D. Leszczynski, et al.; Am. J. Pathol. 145, 1265 (1994) Abstract
Further Categories Containing This Product:
PKA Activators
 
 
ALX-480-046 Revised 17-Sep-08
N2,2'-O-Dibutyrylguanosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS Dibutyryl-cGMP . Na
DBcGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-046-M005   5 mg 40.00 USD Add To Cart
ALX-480-046-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C18H23N5O9P . Na
MW: 484.4 . 23.0
CAS NUMBER: 51116-00-8
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol, DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Activates cGMP-dependent protein kinase (PKG). Cell permeable. For a better and more selective agonist, use 8-pCPT-cGMP (Prod. No. ALX-480-031 or Prod. No. ALX-480-088).
Product Specific Literature References
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
Relaxation of hormonally stimulated smooth muscular tissues by the 8- bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 306, 1 (1979) Abstract
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis, et al.; Mol. Pharmacol. 34, 506 (1988) Abstract
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989) Abstract
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-480-047 Revised 23-Jul-08
5,6-Dichloro-1-β-D-ribofuranosyl benzimidazole 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-5,6-DCl-cBIMPS . Na
5,6-DCI-cBIMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Other Cyclic Nucleotides
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ALX-480-047-C100   100 µg 30.00 USD Add To Cart
ALX-480-047-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C12H10Cl2N2O5PS . Na
MW: 396.2 . 23.0
CAS NUMBER: 120912-54-1
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as PBS (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) and Na2HPO4 (pH 7.0; 2.8 mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent, specific and site selective activator of cAMP-dependent protein kinases especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian phosphodiesterases type I and III and only extremely slowly hydrolyzed by type II. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. ALX-480-045) or 8-CPT-cAMP (Prod. No. ALX-480-030) in terms of metabolic stability, membrane permeability and potency.
Product Specific Literature References
Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells: M. Sandberg, et al.; Biochem J. 279, 521 (1991) Abstract
Further Categories Containing This Product:
PKA Activators
 
 
ALX-480-059 Revised 09-Mar-06
Guanosine 3',5'-cyclic Monophosphate . sodium salt
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SYNONYMS cGMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-059-M025   25 mg 25.00 USD Add To Cart
ALX-480-059-M100   100 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O7P . Na
MW: 344.2 . 23.0
CAS NUMBER: 40732-48-7
MERCK INDEX: 14: 2709
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Intracellular messenger implicated in mediating action of nitric oxide (NO) in many cell types. Target receptors for the second messenger guanosine 3',5'-cyclic monophosphate (cGMP) include protein kinase G (PKG) isozymes, cGMP-dependent ion channels as well as cGMP-responsive phosphodiesterases. In presence of corresponding phosphodiesterases cGMP is metabolized rapidly. Suppresses apoptosis.
Product Specific Literature References
Cyclic GMP metabolism and involvement in biological regulation: N.D. Goldberg & M.K. Haddox; Ann. Rev. Biochem. 46, 823 (1977) Abstract
Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production: S.Y. Chun, et al.; Endocrinology 136, 3120 (1995) Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-480-072 Revised 16-Jun-06
Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
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SYNONYMS Rp-cGMPS . Na
cGMPS . Na, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-072-M001   1 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O6SP . Na
MW: 360.3 . 23.0
CAS NUMBER: 86562-09-6 (free acid)
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.
Product Specific Literature References
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract
Further Categories Containing This Product:
PKG Inhibitors
 
 
ALX-480-073 Revised 06-Dec-04
Guanosine-3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-cGMPS . Na
cGMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-073-MC05   0.5 mg 95.00 USD Add To Cart
ALX-480-073-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O6SP . Na
MW: 360.3 . 23.0
CAS NUMBER: 86562-10-9 (free acid)
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Metabolically resistant activator of cGMP-dependent protein kinases (PKGs). Low membrane permeability.
Product Specific Literature References
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase: S.L. Archer, et al.; PNAS 91, 7583 (1994) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
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