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DNA Fragmentation, Damage & Repair
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ALX-804-733 Revised 05-Feb-08
Monoclonal Antibody to Ribosomal Protein S3 (human) (RP159-1)
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SYNONYMS anti-RPS3 (human) MAb (RP159-1)
anti-40S Ribosomal Protein S3 (human) MAb (RP159-1)
anti-IMR-90 Ribosomal Protein S3 (human) MAb (RP159-1)
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins / Related Products
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ALX-804-733-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: RP159-1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human ribosomal protein S3.
SPECIFICITY: Recognizes human ribosomal protein S3.
APPLICATION: ELISA (direct and indirect: 1:500-1:5’000)
Western Blot (1:500-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 17, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • DNA Endonucleases / Related Products • MAPK Pathway Other Products • NF-kB Pathway Other Products • DNA Endonucleases / Related Products • Monoclonal Antibodies
 
 
ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
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SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-010-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 67604-48-2
MERCK INDEX: 14: 6424
PURITY: ≥95%
APPEARANCE: Light yellow to tan powder.
SOLUBILITY: Soluble in 100% ethanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Natural Products - Antitumor Reagents • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products - Antioxidants • Natural Products - Other Signal Transduction Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • DNA Repair Other Products
 
 
ALX-460-008 Revised 02-Jun-06
Nicotinamide
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SYNONYMS Niacinamide
3-Pyridinecarboxylic amide
Vitamin PP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism / Related Products
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ALX-460-008-G010   10 g 10.00 USD Add To Cart
Product Specification
FORMULA: C6H6N2O
MW: 122.1
CAS NUMBER: 98-92-0
MERCK INDEX: 14: 6523
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water; also soluble in 100 % ethanol or glycerol; slightly soluble in chloroform; almost insoluble in ether or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Susceptible to hydrolysis in acidic or alkaline solution.
HANDLING: Protect from light.
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Further Categories Containing This Product:
Vitamins • DNA Repair Other Products • PARP Inhibitors
 
 
ALX-480-058 Revised 18-Jun-08
8-Nitroguanine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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ALX-480-058-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C5H4N6O3
MW: 196.1
CAS NUMBER: 168701-80-2
PURITY: ≥98% (HPLC)
SOLUBILITY: Slightly soluble in water (sonification).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination: V. Yermilov, et al.; FEBS Lett. 376, 207 (1995) Abstract
Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion: H. Ohshima, et al.; Free Radic. Biol. Med. 25, 1057 (1998) Abstract
Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo: J. Tuo, et al.; Free Radic. Biol. Med. 29, 147 (2000) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-270-370 Revised 01-Jul-08
NU1025
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SYNONYMS 8-Hydroxy-2-methylquinazoline-4-one
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-370-M001   1 mg 30.00 USD Add To Cart
ALX-270-370-M005   5 mg 90.00 USD Add To Cart
ALX-270-370-M025   25 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C9H8N2O2
MW: 176.2
CAS NUMBER: 90417-38-2
PURITY: ≥98%
FORMULATION: Off-white to purple solid.
SOLUBILITY: Soluble in DMSO (25mg/ml). This solution can be further diluted 1:100 in tissue culture medium before use.
RECONSTITUTION: Reconstitute with DMSO.
SHIPPING: AMBIENT
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.

Product Description
A potent poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor (IC50=400nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC, the DNA strand break-inducing drug temozolomide (Prod. No. ALX-420-044), topotecan (Prod. No. ALX-350-133), bleomycin (Prod. No. ALX-630-107), and ionizing radiation effective in murine L1210 leukemia cells, CHO, and in a variety of human tumor cell lines.
Product Specific Literature References
Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors: S. Boulton, et al.; Br. J. Cancer 72, 849 (1995) Abstract
Nephron-sparing surgery for renal cell carcinoma: J.H. Griffin & R.C. Flanigan; Tech. Urol.
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064: K.J. Bowman, et al.; Br. J. Cancer 78, 1269 (1998) Abstract
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP): R.J. Griffin, et al.; J. Med. Chem. 41, 5247 (1998) Abstract
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage: S. Boulton, et al.; Carcinogenesis 20, 199 (1999) Abstract; Full Text
Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines: C.A. Delaney, et al.; Clin. Cancer Res. 6, 2860 (2000) Abstract; Full Text
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-400-036 Revised 31-Oct-06
Peroxynitrite . tetramethylammonium
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SYNONYMS ONOO- . C4H12N
Oxoperoxonitrate(1-) . C4H12N
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
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ALX-400-036-L001   1 ml 152.00 USD Add To Cart
ALX-400-036-5001   5x1 ml 475.00 USD Add To Cart
Product Specification
FORMULA: NO3 . C4H12N
MW: 62.0 . 74.1
CAS NUMBER: 14042-01-4
CONCENTRATION: ~10mM
FORMULATION: Liquid. In 0.01M KOH.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 month after receipt when stored at -80°C.
HANDLING: Protect from light.
HAZARD: OXIDIZING. CORROSIVE.

Product Description
Produced from the reaction of nitrogen monoxide with tetramethylammonium superoxide according to the method of D.S. Bohle, et al. described in Meth. Enzymol. 269, 302 (1996), and dissolved in 0.01M potassium hydroxide (KOH). This formulation of peroxynitrite has a low nitrite content (~1%), no hydrogen peroxide.
Product Specific Literature References
DNA damage induced by peroxynitrite: subsequent biological effects: C. Szabo & H. Ohshima; Nitric Oxide 1, 373 (1997), (Review) Abstract
Peroxynitrite: a biologically significant oxidant: M.P. Murphy, et al.; Gen. Pharmacol. 31, 179 (1998), (Review) Abstract
Peroxynitrite: an endogenous oxidizing and nitrating agent: C. Ducrocq, et al.; Cell. Mol. Life Sci. 55, 1068 (1999), (Review) Abstract
The chemistry of DNA damage from nitric oxide and peroxynitrite: S. Burney, et al.; Mutat. Res. 424, 37 (1999), (Review) Abstract
Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications: S.P. Goss, et al.; Free Radic. Res. 31, 597 (1999), (Review) Abstract
Peroxynitrite: reactive, invasive and enigmatic: J.T. Groves; Curr. Opin. Chem. Biol. 3, 226 (1999), (Review) Abstract
Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies: B. Halliwell, et al.; Free Radic. Res. 31, 651 (1999), (Review) Abstract
Assessment of peroxynitrite scavengers in vitro: B. Halliwell, et al.; Meth. Enzymol. 301, 333 (1999), (Review) Abstract
Chemistry of peroxynitrite and its relevance to biological systems: W.H. Koppenol; Met. Ions Biol. Syst. 36, 597 (1999), (Review) Abstract
Conformation of peroxynitrite: determination by crystallographic analysis: M. Worle, et al.; Chem. Res. Toxicol 12, 305 (1999) Abstract
Peroxynitrite scavenging by metalloporphyrins and thiolates: J.P. Crow; Free Radic. Biol. Med. 28, 1487 (2000), (Review) Abstract
Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics: H. Sies & G.E. Arteel; Free Radic. Biol. Med. 28, 1451 (2000), (Review) Abstract
Reactions of Peroxynitrite with Phenolic and Carbonyl Compounds: Flavonoids are not Scavengers of Peroxynitrite: S. Tibi & W.H. Koppenol; Helv. Chim. Acta 83, 2412 (2000)
BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death: L. Virag & C. Szabo; Free Radic. Biol. Med. 29, 704 (2000) Abstract
Peroxynitrite promotes mitochondrial permeability transition-dependent rapid u937 cell necrosis: survivors proliferate with kinetics superimposable on those of untreated cells: P. Sestili, et al.; Free Radic Res. 34, 513 (2001) Abstract
Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention: L. Virag, et al.; Toxicol. Lett. 140-141, 113 (2003), (Review) Abstract
Preventing nitrite contamination in tetramethylammonium peroxynitrite solutions: P. Latal, et al.; Inorg. Chem. 43, 6519 (2004) Abstract
Further Categories Containing This Product:
PARP Other Products • DNA Repair Other Products
 
 
ALX-270-251 Revised 20-Oct-08
6(5H)-Phenanthridinone
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-251-M010   10 mg 15.00 USD Add To Cart
Product Specification
FORMULA: C13H9NO
MW: 195.2
CAS NUMBER: 1015-89-0
RTECS: SG0370000
PURITY: ≥95%
APPEARANCE: Light brown solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Poly(ADP-ribose)polymerase (PARP) inhibitor.
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor: D. Weltin, et al.; Int. J. Immunopharmacol. 17, 265 (1995) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis: D. Weltin, et al.; Biochem. Pharmacol. 51, 1123 (1996) Abstract
Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells: D. Weltin, et al.; Int. J. Radiat. Biol. 72, 685 (1997) Abstract
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase: M.R. Cookson, et al.; J. Neurochem. 70, 501 (1998) Abstract
Effects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells: D.S. Richardson, et al.; Adv. Exp. Med. Biol. 457, 267 (1999) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-289 Revised 20-Oct-08
PJ-34
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SYNONYMS N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-289-M001   1 mg 50.00 USD Add To Cart
ALX-270-289-M005   5 mg 125.00 USD Add To Cart
ALX-270-289-M025   25 mg 375.00 USD Add To Cart
Product Specification
FORMULA: C17H17N3O2 . HCl
MW: 295.2 . 36.5
PURITY: ≥98% (NMR)
APPEARANCE: White to light brown powder.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for 2 years after receipt when stored at +4C°. Stock solutions are stable for 3 weeks when stored at room temperature.
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50=20nM compared to EC50=200µM of the prototypical PARP inhibitor 3-aminobenzamide (Prod. No. ALX-270-044)). Inhibits peroxynitrite (Prod. No. ALX-400-036)-induced cell necrosis (EC50=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.
Product Specific Literature References
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke: G.E. Abdelkarim, et al.; Int. J. Mol. Med. 7, 255 (2001) Abstract
Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes: P. Bai, et al.; Free Radic. Biol. Med. 31, 1616 (2001) Abstract
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation: F. Garcia Soriano, et al.; Nat. Med. 7, 108 (2001) Abstract
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase: J.G. Mabley, et al.; Inflamm. Res. 50, 561 (2001) Abstract
Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor: R. Faro, et al.; Ann. Thorac. Surg. 73, 575 (2002) Abstract
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents: P. Jagtap, et al.; Crit. Care Med. 30, 1071 (2002) Abstract
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging: P. Pacher, et al.; Int. J. Mol. Med. 9, 659 (2002) Abstract
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure: P. Pacher, et al.; J. Am. Coll. Cardiol. 40, 1006 (2002) Abstract
Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia: Z. Ivanyi, et al.; Shock 19, 415 (2003) Abstract; Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
General Literature References
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors: L. Virag and C. Szabo; Pharmacol. Rev. 54, 375 (2002), (Review) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Non-apoptotic Cell Death / Necrosis
 
 
ALX-210-552 Revised 31-Oct-06
Polyclonal Antibody to Apurinic/Apyrimidinic Endonuclease
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SYNONYMS anti-APE1 PAb
anti-APEX PAb
anti-HAP1 PAb
anti-Ref-1 PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Endonucleases / Related Products
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ALX-210-552-R100   100 µl 290.00 USD