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DNA Regulation / Transcription
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AG-N0823 Revised 17-Jun-08 New product
Nampt/Visfatin (human/rat) (IntraCellular) Dual ELISA Kit
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin/Nampt/PBEF/Related Products
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AG-N0823EK-KI01   96 wells 640.00 USD Add To Cart
AG-N0823TP-KI01 Twin Plex 2x96 wells 940.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SENSITIVITY: 30pg/ml (range 0 to 32ng/ml)
SPECIFICITY: Does not cross-react with mouse sera.
APPLICATION: For the quantitative determination of Nampt/Visfatin in human or rat cell lysates.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • NAD+ Metabolism/Related Products
 
 
AG-V0523 Revised 24-Jul-08
Nampt/Visfatin (human) ELISA Kit
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SYNONYMS Nicotinamide Phosphoribosyltransferase (human) ELISA Kit
PBEF1 (human) ELISA Kit
Pre-B-Cell Colony Enhancing Factor 1 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin/Nampt/PBEF/Related Products
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AG-V0523EK-KI01   96 wells 660.00 USD Add To Cart
AG-V0523PP-KI01 Penta Plex 5x96 wells 2'050.00 USD Add To Cart
AG-V0523TP-KI01 Twin Plex 2x96 wells 920.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 30pg/ml (range 0 to 16ng/ml)
SPECIFICITY: Does not cross-react with mouse Nampt/visfatin. Has been shown to specifically detect the physologically relevant Nampt/visfatin dimer in human serum samples (see [2]).
APPLICATION: For the quantitative determination of human Nampt/visfatin in serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
[1] Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway: T. Yonezawa, et al.; FEBS Lett. 580, 6635 (2006) Abstract
[2] Molecular Characteristics of Serum Visfatin and Differential Detection by Immunoassays: A. Korner, et al.; J. Clin. Endocrinol. Metab. 92, 4783 (2007) Abstract; Full Text
[3] Correlation of circulating full-length visfatin (PBEF/Nampt) with metabolic parameters in subjects with and without diabetes: a cross-sectional study: R. Retnakaran, et al.; Clin. Endocrinol. (Oxf) Epub ahead of print, (2008) Abstract
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
ELISA & EIA Kits • NAD+ Metabolism/Related Products
 
 
ALX-158-001 Revised 28-Feb-06
Histone H1-7 Substrate
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histones/Related Products
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ALX-158-001-M001   1 mg 70.00 USD Add To Cart
ALX-158-001-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Arg-Lys-Ala-Ser-Gly-Pro-OH
FORMULA: C31H58N14O9
MW: 770.9
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA). The peptide is derived from the phosphorylation site (Ser38) in calf thymus histone H1.
Product Specific Literature References
Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase: A.H. Pomerantz, et al.; PNAS 74, 4261 (1977) Abstract
Further Categories Containing This Product:
Peptides • PKA Substrates
 
 
ALX-158-002 Revised 28-Feb-06
[Ala32]-Histone H2B (29-35)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histones/Related Products
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ALX-158-002-M001   1 mg 75.00 USD Add To Cart
ALX-158-002-M005   5 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH
FORMULA: C38H74N18O10
MW: 943.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of cGMP-dependent protein kinase, derived by a serine-to-alanine substitution at position 32 of histone H2B (29-35). For the corresponding unsubstituted histone fragment see Prod. No. ALX-158-003.
Product Specific Literature References
D.B. Glass & M.D. Miller; Fed. Proc. 39, 867 (1980)
Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors: D.B. Glass; Biochem. J. 213, 159 (1983) Abstract
Further Categories Containing This Product:
Peptides • PKG Inhibitors
 
 
ALX-158-003 Revised 04-Jul-03
Histone H2B (29-35)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histones/Related Products
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ALX-158-003-M001   1 mg 50.00 USD Add To Cart
ALX-158-003-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Ser-Arg-Lys-Glu-OH
FORMULA: C38H74N18O11
MW: 959.1
PURITY: ≥97%
APPEARANCE: White powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cGMP-dependent protein kinase corresponding to residues 29-35 of histone H2B. For the corresponding alanine-for-serine substituted peptides see Prod. No. ALX-158-002 and Prod. No. ALX-158-004.
Product Specific Literature References
Comparison of the substrate specificity of adenosine 3':5'- monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to phosphorylation sites in histone H2B: D.B. Glass & E.G. Krebs; J. Biol. Chem. 254, 9728 (1979) Abstract; Full Text
Further Categories Containing This Product:
PKG Substrates • Peptides • Guanylyl Cyclases, Guanosine Phosphate Metabolism/Related Products
 
 
ALX-158-004 Revised 13-Jan-05
[Ala34]-Histone H2B (29-35)
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Histones/Related Products
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ALX-158-004-M001   1 mg 60.00 USD Add To Cart
ALX-158-004-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH
FORMULA: C35H67N17O11
MW: 902.0
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cGMP-dependent protein kinase. For the corresponding unsubstituted histone fragment see Prod. No. ALX-158-003.
Product Specific Literature References
Phosphorylation by guanosine 3':5'-monophosphate-dependent protein kinase of synthetic peptide analogs of a site phosphorylated in histone H2B: D.B. Glass & E.G. Krebs; J. Biol. Chem. 257, 1196 (1982) Abstract; Full Text
Further Categories Containing This Product:
PKG Substrates • Peptides
 
 
ALX-162-017 Revised 08-Jan-03
N-Myristoyl-Lys-Arg-Thr-Leu-Arg-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-162-017-M001   1 mg 70.00 USD Add To Cart
ALX-162-017-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C42H82N12O8
MW: 883.2
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.
Product Specific Literature References
Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C: C.G. Ioannides, et al.; Cell. Immunol. 131, 242 (1990) Abstract
N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor: C.A. O'Brian, et al.; Biochem. Pharmacol. 39, 49 (1990) Abstract
Further Categories Containing This Product:
Peptides • Histones/Related Products
 
 
ALX-163-011 Revised 14-Jul-08
NBD Peptide /  NF-κB Blocker (cell permeable)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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ALX-163-011-1   1 Vial 240.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-TALDWSWLQTE-amide
FORMULA: C121H202N48O32
MW: 2841.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Protect from moisture. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo: E. Jimi, et al.; Nature Med. 10, 617 (2004) Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M.J. May, et al.; Science 289, 1550 (2000) Abstract
Characterization of the Ikappa B-kinase NEMO binding domain: M.J. May, et al.; J. Biol. Chem. 277, 45992 (2002) Abstract
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Further Categories Containing This Product:
Peptides
 
 
ALX-167-024 Revised 17-May-06
SN50
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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ALX-167-024-C500   500 µg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
FORMULA: C129H230N36O29S
MW: 2781.5
PEPTIDE CONTENT: 50-75%
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
FORMULATION: Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in distilled water, 100% ethanol or ethanol:water 1:1.
RECONSTITUTION: Reconstitute in sterile distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptides in solution have limited stability.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50µg/ml (18µM). In human monocytic THP-1 cells induced by LPS or TNF-α there was 85% inhibition at 100µg/ml. For control peptide, see SN50M (Prod. No. ALX-167-025).
Product Specific Literature References
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence: Y.Z. Lin, et al.; J. Biol. Chem. 270, 14255 (1995) Abstract; Full Text
p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism: K.K. Meja, et al.; Br. J. Pharmacol. 131, 1143 (2000) Abstract
Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis: M. Niwa, et al.; Eur. J. Pharmacol 407, 211 (2000) Abstract
Activation of nuclear factor kappaB and induction of apoptosis by tumor necrosis factor-alpha in the mouse uterine epithelial WEG-1 cell line: S. Pampfer, et al.; Biol. Reprod. 63, 879 (2000) Abstract
Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells: Y. Dai, et al.; Blood 103, 2761 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Nuclear localization sequence (NLS) aa 360-369 (AAVALLPAVLLALLAPVQRKRQKLMP) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF).
Further Categories Containing This Product:
Nuclear Envelope & Nuclear Transport • Peptides
 
 
ALX-167-025 Revised 17-May-06
SN50M Control Peptide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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