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Poly(ADP-ribose) Polymerase [PARP]/Related Products
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP]/Related Products
 
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AG-N0823 Revised 26-Aug-08 New product
Nampt/Visfatin (human) (IntraCellular) ELISA Kit
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin/Nampt/PBEF/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-N0823EK-KI01   96 wells 640.00 USD Add To Cart
AG-N0823TP-KI01 Twin Plex 2x96 wells 940.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 30pg/ml (range 0 to 32ng/ml)
SPECIFICITY: Does not cross-react with mouse sera.
APPLICATION: For the quantitative determination of Nampt/Visfatin in human cell lysates.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • NAD+ Metabolism/Related Products
 
 
AG-V0523 Revised 24-Jul-08
Nampt/Visfatin (human) ELISA Kit
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SYNONYMS Nicotinamide Phosphoribosyltransferase (human) ELISA Kit
PBEF1 (human) ELISA Kit
Pre-B-Cell Colony Enhancing Factor 1 (human) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin/Nampt/PBEF/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-V0523EK-KI01   96 wells 660.00 USD Add To Cart
AG-V0523TP-KI01 Twin Plex 2x96 wells 920.00 USD Add To Cart
AG-V0523PP-KI01 Penta Plex 5x96 wells 2'050.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 30pg/ml (range 0 to 16ng/ml)
SPECIFICITY: Does not cross-react with mouse Nampt/visfatin. Has been shown to specifically detect the physiologically relevant Nampt/visfatin dimer in human serum samples (see [2]).
APPLICATION: For the quantitative determination of human Nampt/visfatin in serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
[1] Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway: T. Yonezawa, et al.; FEBS Lett. 580, 6635 (2006) Abstract
[2] Molecular Characteristics of Serum Visfatin and Differential Detection by Immunoassays: A. Korner, et al.; J. Clin. Endocrinol. Metab. 92, 4783 (2007) Abstract; Full Text
[3] Correlation of circulating full-length visfatin (PBEF/Nampt) with metabolic parameters in subjects with and without diabetes: a cross-sectional study: R. Retnakaran, et al.; Clin. Endocrinol. (Oxf) Epub ahead of print, (2008) Abstract
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • NAD+ Metabolism/Related Products
 
 
AG-VN0812 Revised 07-Jul-08 New product
Nampt/Visfatin (mouse) ELISA Kit
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SYNONYMS Nicotinamide Phosphoribosyltransferase (mouse) ELISA Kit
PBEF1 (mouse) ELISA Kit
Pre-B-Cell Colony Enhancing Factor 1 (mouse) ELISA Kit
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin/Nampt/PBEF/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-VN0812EK-KI01   96 wells 660.00 USD Add To Cart
AG-VN0812TP-KI01 Twin Plex 2x96 wells 920.00 USD Add To Cart
AG-VN0812PP-KI01 Penta Plex 5x96 wells 2'050.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SENSITIVITY: 50pg/ml (range 0 to 64ng/ml)
SPECIFICITY: Does not cross-react with human or rat Nampt/visfatin.
APPLICATION: For the quantitative determination of mouse Nampt/visfatin in serum.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • NAD+ Metabolism/Related Products
 
 
ALX-190-001 Revised 20-Jun-08
H-Trp-Glu-OH
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SYNONYMS H-WE-OH
G3335
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-190-001-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C16H19N3O5
MW: 333.3
CAS NUMBER: 36099-95-3
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone (Prod. No. ALX-350-125) in a dose-dependent manner (IC50=31.9µM).
Product Specific Literature References
The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation: F. Ye, et al.; Chembiochem. 7, 74 (2006) Abstract
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator activated receptors: N. B. Mettu, et al.; Mol. Endocrinol. 21, 2361 (2007) Abstract; Full Text
 
 
ALX-201-063 Revised 25-Oct-06
PARP-1 (human) (recombinant) (high purity)
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SYNONYMS Poly(ADP-ribose) Polymerase-1 (human) (recombinant) (high purity)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP-1
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ALX-201-063-C020   20 µg 348.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in Sf9 cells.
CONCENTRATION: 1mg/ml.
PURITY: ≥99% (SDS-PAGE
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 100mM TRIS-HCl, pH 7.5,containing 14mM β-mercaptoethanol, 0.5mM EDTA, 0.5mM PMSF and 10% glycerol.
SPECIFIC ACTIVITY: ≥600U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min. at 25°C, pH 7.5.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Overproduction and large-scale purification of the human poly(ADP- ribose) polymerase using a baculovirus expression system: H. Giner, et al.; Gene 114, 279 (1992) Abstract
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem. 279, 5244 (2004) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P09874: PARP-1 (human)
Related Products
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-064 Revised 25-Oct-06
PARP-2 (mouse) (recombinant) (high purity)
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SYNONYMS Poly(ADP-ribose) Polymerase-2 (mouse) (recombinant) (high purity)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP-2
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ALX-201-064-C020   20 µg 368.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in Sf9 cells.
CONCENTRATION: ~1mg/ml
PURITY: ≥98% (SDS-PAGE)
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 100mM TRIS-HCl, pH 7.5, containing 14mM β-mercaptoethanol, 0.5mM EDTA, 0.5mM PMSF and 10% glycerol.
SPECIFIC ACTIVITY: ≥380U/mg protein. One unit is defined as the amount of enzyme that synthesizes 1nmol of poly(ADP-ribose) per min at 25°C, pH 7.5. See also separate protocol (link below).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase: J.C. Ame, et al.; J. Biol. Chem. 274, 17860 (1999) Abstract; Full Text
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene: J.C. Ame, et al.; J. Biol. Chem. 276, 11092 (2001) Abstract; Full Text
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing: M. Malanga & F.R. Althaus; J. Biol. Chem. 279, 5244 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O88554: PARP-2 (mouse)
Related Products
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-170 Revised 25-Oct-06
PARP-3 (human) (recombinant) (high purity)
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SYNONYMS Poly(ADP-ribose) Polymerase-3 (human) (recombinant) (high purity)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP-3
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-170-C020   20 µg 368.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in Sf9 cells.
CONCENTRATION: 0.38mg/ml
PURITY: ≥97%
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 0.25mM EDTA, 7mM β-mercaptoethanol, 0.25mM PMSF and 10% glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression: A. Augustin, et al.; J. Cell Sci. 116, 1551 (2003) Abstract; Full Text
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function: P. Chang et al.; Nature Cell Biology 7, 1133 (2005)
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-232 Revised 18-Mar-08
PARP-1 (Catalytic Domain) (human) (recombinant) (His)
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SYNONYMS Poly(ADP-ribose) Polymerase-1 (Catalytic Domain) (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP-1
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-232-C020   20 µg 380.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in SF21 cells. Human PARP-1 (aa 656-1014) is fused to a His-tag.
CONCENTRATION: 1.5mg/ml.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 300mM sodium chloride, 250mM imidazole, 2mM β-mercaptoethanol, 0.2% NP-40 and 10% glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P09874: PARP-1 (human)
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-235 Revised 17-Aug-06
NAD Kinase (full length) (active) (human) (recombinant) (His)
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SYNONYMS NADK (full length) (active) (human) (recombinant) (His)
Poly(P)/ATP NAD Kinase (full length) (active) (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-201-235-C050   50 µg 320.00 USD Add To Cart
Product Specification
EC: 2.7.1.23
SOURCE/HOST: Produced in E. coli. Human NADK is fused at the N-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Free of any nucleotide converting side-activities.
FORMULATION: Ammonium sulphate suspension.
RECONSTITUTION: Prepare working aliquots by centrifugation and dissolve the pellet in 50mM TRIS/HCl pH 7.5, 150mM NaCl, 1mM DTT.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.