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ALX-850-294
Revised 17-Dec-07
Histone Deacetylase Colorimetric Assay Kit
SYNONYMS
HDAC Colorimetric Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Kits & Sets
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-294-KI01
1 Kit
399.00 USD
Product Specification
QUANTITY:
~100 tests
KIT/SET CONTAINS:
500µl HDAC Substrate (Boc-Lys(Ac)-pNA)
1.0ml 10X HDAC Assay Buffer
1.0ml Lysine Developer
10µl HDAC Inhibitor (Trichostatin A)
50µl HeLa Nuclear Extract
20µl Deacetylated Standard (Boc-Lys-pNA)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Description
Kit provides a fast and colorimetric-based method that eliminates radioactivity, extractions, or chromatography, as used in traditional assays. The new procedure requires only two easy steps, both performed in the same microtiter plate. First, the histone deacetylase (HDAC) colorimetric substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity. Deacetylation sensitizes the substrate, so that in the second step, treatment with the lysine developer produces a chromophore. The chromophore can be easily analyzed at 400 or 405nm using an ELISA plate reader or a spectrometer. The assay is well suited for high throughput screening applications. HDAC inhibitors, substrates, and antibodies are also available separately.
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-850-290
Revised 05-Dec-05
Histone Deacetylase Fluorometric Assay Kit
SYNONYMS
HDAC Fluorometric Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Kits & Sets
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-290-KI01
1 Kit
357.00 USD
Product Specification
QUANTITY:
100 tests.
KIT/SET CONTAINS:
500µl HDAC Substrate (Boc-Lys(Ac)-AMC)
1ml 10x HDAC Assay Buffer
1ml Lysine Developer
10µl HDAC Inhibitor (Trichostatin A)
10µl HeLa Nuclear Extract
20µl Deacetylated Standard (Boc-Lys-AMC)
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Description
Kit provides a fast and fluorescence-based method that eliminates radioactivity, extractions, or chromatography, as used in traditional assays. The new procedure requires only two easy steps, both performed in the same microtiter plate. First, the histone deacetylase (HDAC) fluorometric substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity. Deacetylation sensitizes the substrate, so that in the second step, treatment with the lysine developer produces a fluorophore. The fluorophore can be easily analyzed using a fluorescence plate reader or a fluorometer (Ex(max): 380nm; Em(max): 460nm). The assay is well suited for high throughput screening applications. HDAC inhibitors, substrates, and antibodies are also available separately.
Product Specific Literature References
Histone acetylation in chromatin structure and transcription
:
M. Grunstein; Nature
389
, 349 (1997)
Abstract
Acetylation and chromosomal functions
:
W.L. Cheung, et al.; Curr. Opin. Cell Biol.
12
, 326 (2000)
Abstract
The language of covalent histone modifications
:
B.D. Strahl & C.D. Allis; Nature
403
, 41 (2000)
Abstract
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-340-057
Revised 10-Jul-08
12(S)-HpETE
SYNONYMS
12-(S)-Hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Eicosanoids Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-057-C025
25 µg
162.00 USD
ALX-340-057-C050
50 µg
308.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
71774-10-2
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within fifteen minutes.
Product Description
Endogenous TRPV1 agonist (K
i
=0.35µM).
Product Specific Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances
:
S.W. Hwang, et al.; PNAS
97
, 6155 (2000)
Abstract
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
:
J. Shin, et al.; PNAS
99
, 10150 (2002)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fos & Jun Proteins/Related Products
•
Endovanilloids
ALX-340-058
Revised 10-Jul-08
15(S)-HpETE
SYNONYMS
15S-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Eicosanoids Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-058-C025
25 µg
41.00 USD
ALX-340-058-C050
50 µg
79.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
70981-96-3
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml).
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. Product is highly unstable in aqueous solution. We recommend using aqueous solutions within 15 minutes.
Product Description
Endogenous TRPV1 agonist.
Product Specific Literature References
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances
:
S.W. Hwang, et al.; PNAS
97
, 6155 (2000)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Fos & Jun Proteins/Related Products
•
Endovanilloids
ALX-270-474
Revised 22-Oct-07
HSD Inhibitor 23
SYNONYMS
N-(5-Hydroxytricyclo[3.3.1.13,7]dec-2-yl)-α,α-dimethyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazineacetamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-474-M001
1 mg
190.00 USD
Product Specification
FORMULA:
C
24
H
33
F
3
N
4
O
2
MW:
466.5
CAS NUMBER:
868604-75-5
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Selective, potent and cell permeable small molecule inhibitor of 11-β-hydroxysteroid dehydrogenase.
Product Specific Literature References
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors:
J.J. Rohde, et al.; J. Med. Chem.
50
, 149 (2007)
Abstract
;
Full Text
ALX-201-024
Revised 24-Feb-05
HSF1 (human) (recombinant)
SYNONYMS
Heat Shock Factor 1 (human) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Stress & Heat Shock Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-201-024-C150
150 µg
343.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
FORMULATION:
Liquid. Sonicated
E. coli
extract at a total protein concentration of 6mg/ml in 25mM HEPES, pH 7.9, 12.5mM MgCl, 0.1mM EDTA, 10% glycerol, 1mM DTT, 0.1% NP-40 and 300mM KCl and protease inhibitors.
APPLICATION:
Positive control in gel shift assays (25 tests) or Western blot (50 tests) with PAb to HSF1 (Prod. No.
ALX-210-129
). DNase I footprinting and
in vitro
transcription assays.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-20°C
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q00613:
HSF 1 (human)
Further Categories Containing This Product:
Transcription Factors Other Products
•
Recombinant Proteins/Fusion Proteins
ALX-190-001
Revised 20-Jun-08
H-Trp-Glu-OH
SYNONYMS
H-WE-OH
G3335
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PARP Inhibitors
Ordering Information
Product Numbers:
Format:
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ALX-190-001-M050
50 mg
80.00 USD
Product Specification
FORMULA:
C
16
H
19
N
3
O
5
MW:
333.3
CAS NUMBER:
36099-95-3
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone (Prod. No.
ALX-350-125
) in a dose-dependent manner (IC
50
=31.9µM).
Product Specific Literature References
The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation:
F. Ye, et al.; Chembiochem.
7
, 74 (2006)
Abstract
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator activated receptors:
N. B. Mettu, et al.; Mol. Endocrinol.
21
, 2361 (2007)
Abstract
;
Full Text
ALX-480-090
Revised 25-Jul-08
8-Hydroxy-2'-deoxyguanosine
SYNONYMS
8-OHdG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Guanosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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ALX-480-090-M001
1 mg
91.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
5
MW:
283.2
CAS NUMBER:
88847-89-6
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (15mg/ml) or DMSO (12mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Oxidative DNA degradation product.
Product Specific Literature References
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells:
T.S. Lin, et al.; J. Med. Chem.
28
, 1194 (1985)
Abstract
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column:
E.M. Park, et al.; PNAS
89
, 3375 (1992)
Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection:
M.K. Shigenaga, et al.; Meth. Enzymol.
234
, 16 (1994)
Abstract
Oxidative alterations in Alzheimer's disease:
W.R. Markesbery & J.M. Carney; Brain Pathol.
9
, 133 (1999)
Abstract
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine:
K. Asagoshi, et al.; J. Biol. Chem.
275
, 4956 (2000)
Abstract
;
Full Text
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells:
E. Cappelli, et al.; Biochemistry
39
, 10408 (2000)
Abstract
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements:
M.S. Cooke, et al.; Free Radic. Res.
32
, 381 (2000)
Abstract
Further Categories Containing This Product:
DNA Repair Other Products
•
Oxidative Stress Markers & Reagents/Related Products
ALX-370-012
Revised 09-Oct-07
20-Hydroxyecdysone
SYNONYMS
β-Ecdysone
2β,3β,14α,20R,22R,25-Hexahydroxy-5β-cholest-7-en-6-one
Ecdysterone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Ecdysteroids
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-370-012-M005
5 mg
55.00 USD
ALX-370-012-M010
10 mg
90.00 USD
ALX-370-012-M050
50 mg
350.00 USD
Product Specification
FORMULA:
C
27
H
44
O
7
MW:
480.6
CAS NUMBER:
5289-74-7
MERCK INDEX:
14:
3491
PURITY:
≥95%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of
Drosophila melanogaster.
Product Specific Literature References
H. Hampshire and D.H.S. Horn; Chem. Commun. 37 (1966)
M.N. Galbraith and D.H.S. Horn; Chem. Commun. 905 (1966)
H. Rimpler and G. Schulz; THL
22
, 2033 (1967)
L. Canonica, et al.; Phytochemistry
14
, 525 (1975)
Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death:
C. Cao, et al.; J. Cell Biol.
176
, 843 (2007)
Abstract
Further Categories Containing This Product:
Forkhead Box [FOX] Proteins/Related Products
•
Non-apoptotic Cell Death/Necrosis
ALX-480-091
Revised 28-Nov-07
8-Hydroxyguanine
SYNONYMS
8-Oxoguanine
7,8-Dihydro-8-oxoguanine
8-oxoG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Nucleobases
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-480-091-M010
10 mg
30.00 USD
Product Specification
FORMULA:
C
5
H
5
N
5
O
2
MW:
167.1
CAS NUMBER:
5614-64-2
PURITY:
≥90% (contains <10% acetic acid)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in conc. sodium hydroxide. May be further diluted and neutralized with water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer:
P. Jaruga, et al.; FEBS Lett.
341
, 59 (1994)
Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection:
M.K. Shigenaga, et al.; Meth. Enzymol.
234
, 16 (1994)
Abstract
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells:
J.P. Spencer, et al.; FEBS Lett.
374
, 233 (1995)
Abstract
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions:
T.H. Zastawny, et al.; Free Radic. Biol. Med.
18
, 1013 (1995)
Abstract
Oxidative denitrification of the antitumour drug hydroxyguanidine:
S.A. Everett, et al.; Free Radic. Biol. Med.
24
, 1 (1998)
Abstract
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage:
H.J. Helbock, et al.; Meth. Enzymol.
300
, 156 (1999)
Abstract
Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1:
J.W. Hyun, et al.; Oncogene
19
, 4476 (2000)
Abstract
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme:
N.Y. Tretyakova, et al.; Chem. Res. Toxicol.
13
, 658 (2000)
Abstract
Further Categories Containing This Product:
DNA Repair Other Products
•
Oxidative Stress Markers & Reagents/Related Products
ALX-480-075
Revised 14-Jun-06
8-Hydroxyguanosine
SYNONYMS
8-OHG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
