• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
DNA Fragmentation, Damage & Repair
You are here: Product Lines > DNA Regulation / Transcription > DNA Fragmentation, Damage & Repair
 
Toolbar - View Selection
 
 Items 20-40 of 66 Page 2 of 4 Select Page: << 1 2 3 4  >>  
ALX-480-100 Revised 27-Mar-08 New product
Fludarabine
Add to Clipboard
SYNONYMS 2-Fluoroadenine-9-β-D-arabinofuranoside
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-100-M005   5 mg 45.00 USD Add To Cart
ALX-480-100-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C10H12FN5O4
MW: 285.2
CAS NUMBER: 21679-14-1
MERCK INDEX: 14: 4126
RTECS: AU6207000
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow crystalline powder.
SOLUBILITY: Sparingly soluble in water or organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
IDENTITY: Determined by IR.

Product Description

Prodrug converted to the free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as the 5’-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells. Inhibits RNA transcription.
Product Specific Literature References
Fludarabine: a new agent with major activity against chronic lymphocytic leukemia: M.J. Keating, et al.; Blood 74, 19 (1989) Abstract; Full Text
Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity: P. Huang, et al.; J. Biol. Chem. 265, 16617 (1990) Abstract; Full Text
Action of 9-beta-D-arabinofuranosyl-2-fluoroadenine on RNA metabolism: P. Huang & W. Plunkett; Mol. Pharmacol. 39, 449 (1991) Abstract
Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine: P. Huang, et al.; Leukemia 14, 1405 (2000) Abstract
Role of fludarabine in hematological malignancies: M. Montillo, et al.; Expert Rev. Anticancer Ther. 6, 1141 (2006) Abstract
Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells: C. Pepper, et al.; Br. J. Cancer 97, 253 (2007) Abstract
Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway: C. Nishioka, et al.; Leukemia 21, 1044 (2007) Abstract
Further Categories Containing This Product:
Transcription Inhibitors/Related Products • DNA Repair Other Products • DNA Replication Other Products
 
 
ALX-350-017 Revised 22-Apr-08
Fumonisin B1
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-017-M001   1 mg 60.00 USD Add To Cart
ALX-350-017-M005   5 mg 245.00 USD Add To Cart
Product Specification
FORMULA: C34H59NO15
MW: 721.8
CAS NUMBER: 116355-83-0
MERCK INDEX: 14: 4289
RTECS: TZ8350000
SOURCE/HOST: Isolated from Fusarium moniliforme.
PURITY: ~98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. MAY BE TERATOGENIC. HARMFUL.

Product Description
Mycotoxin. Induces DNA damage in the liver and cancer. Inhibitor of sphingosine biosynthesis. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.
Product Specific Literature References
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 14486 (1991) Abstract; Full Text
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem. 268, 27299 (1993) Abstract; Full Text
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993) Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996) Abstract
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis 21, 1537 (2000) Abstract
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci. 61, 6 (2001), Review Abstract
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology 232, 163 (2007) Abstract
Further Categories Containing This Product:
Akt [PKB]/Related Products • Carcinogens & Tumor Promoters Other Products • Sphingolipids & Glycosphingolipids Other Products • Mycotoxins • DNA Damage & Repair Other Products • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-418 Revised 16-Jun-08
Gallotannin
Add to Clipboard
SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • DNA Repair Other Products • Natural Products - Nitric Oxide Pathway Modulators • Free Radical Scavengers
 
 
ALX-350-303 Revised 12-Feb-07
Heraclenin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-303-M002   2 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C16H14O5
MW: 286.3
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in methanol or water. Almonst insoluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
The furanocoumarins heraclenin (Prod. No. ALX-350-303) and imperatorin (Prod. No. ALX-350-302) inhibit T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Both compounds also induce apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.
Product Specific Literature References
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin: G. Appendino, et al.; J. Nat. Prod. 67, 532 (2004) Abstract
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT: N. Marquez, et al.; Planta Med. 70, 1016 (2004) Abstract
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway: R. Sancho, et al.; J. Biol. Chem. 279, 37349 (2004) Abstract; Full Text
Related Products
Further Categories Containing This Product:
DNA Fragmentation & Chromatin Condensation
 
 
ALX-480-090 Revised 25-Jul-08
8-Hydroxy-2'-deoxyguanosine
Add to Clipboard
SYNONYMS 8-OHdG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-090-M001   1 mg 91.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O5
MW: 283.2
CAS NUMBER: 88847-89-6
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (15mg/ml) or DMSO (12mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column: E.M. Park, et al.; PNAS 89, 3375 (1992) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
Oxidative alterations in Alzheimer's disease: W.R. Markesbery & J.M. Carney; Brain Pathol. 9, 133 (1999) Abstract
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine: K. Asagoshi, et al.; J. Biol. Chem. 275, 4956 (2000) Abstract; Full Text
Efficient repair of 8-oxo-7,8-dihydrodeoxyguanosine in human and hamster xeroderma pigmentosum D cells: E. Cappelli, et al.; Biochemistry 39, 10408 (2000) Abstract
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements: M.S. Cooke, et al.; Free Radic. Res. 32, 381 (2000) Abstract
Further Categories Containing This Product:
Oxidative Stress Markers & Reagents/Related Products • DNA Repair Other Products
 
 
ALX-480-091 Revised 28-Nov-07
8-Hydroxyguanine
Add to Clipboard
SYNONYMS 8-Oxoguanine
7,8-Dihydro-8-oxoguanine
8-oxoG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-091-M010   10 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C5H5N5O2
MW: 167.1
CAS NUMBER: 5614-64-2
PURITY: ≥90% (contains <10% acetic acid)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in conc. sodium hydroxide. May be further diluted and neutralized with water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer: P. Jaruga, et al.; FEBS Lett. 341, 59 (1994) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells: J.P. Spencer, et al.; FEBS Lett. 374, 233 (1995) Abstract
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions: T.H. Zastawny, et al.; Free Radic. Biol. Med. 18, 1013 (1995) Abstract
Oxidative denitrification of the antitumour drug hydroxyguanidine: S.A. Everett, et al.; Free Radic. Biol. Med. 24, 1 (1998) Abstract
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage: H.J. Helbock, et al.; Meth. Enzymol. 300, 156 (1999) Abstract
Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1: J.W. Hyun, et al.; Oncogene 19, 4476 (2000) Abstract
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme: N.Y. Tretyakova, et al.; Chem. Res. Toxicol. 13, 658 (2000) Abstract
Further Categories Containing This Product:
Oxidative Stress Markers & Reagents/Related Products • DNA Repair Other Products
 
 
ALX-480-075 Revised 14-Jun-06
8-Hydroxyguanosine
Add to Clipboard
SYNONYMS 8-OHG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Guanosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-075-M001   1 mg 30.00 USD Add To Cart
ALX-480-075-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O6
MW: 299.2
CAS NUMBER: 3868-31-3
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.
Product Specific Literature References
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem. 28, 1194 (1985) Abstract
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS 89, 11021 (1992) Abstract
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res. 413, 143 (1998) Abstract
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med. 28, 13 (2000) Abstract
Further Categories Containing This Product:
Nucleic Acid Oxidation & Alkylation/Related Products
 
 
ALX-480-092 Revised 11-Dec-06
Hydroxymethyl uracil
Add to Clipboard
SYNONYMS 5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-092-G001   1 g 43.00 USD Add To Cart
Product Specification
FORMULA: C5H6N2O3
MW: 142.1
CAS NUMBER: 4433-40-3
RTECS: YR0513000
PURITY: ≥98%
APPEARANCE: White to off-white crystallline solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or 100% ethanol; also soluble in PBS, pH 7.2.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at –20 °C. We do not recommend storing the aqueous solution for more than one day.

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer: P. Jaruga, et al.; FEBS Lett. 341, 59 (1994) Abstract
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells: J.P. Spencer, et al.; FEBS Lett. 374, 233 (1995) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-279 Revised 01-Jun-06
4-Hydroxyquinazoline
Add to Clipboard
SYNONYMS 4-Quinazolinol
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-279-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C8H6N2O
MW: 146.2
CAS NUMBER: 491-36-1
RTECS: VA2300000
PURITY: ≥98%
APPEARANCE: White to grey solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-350-302 Revised 14-Dec-07
Imperatorin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-302-M002