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ALX-270-484
Revised 07-Apr-08
AGK2
SYNONYMS
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins/Related Products
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ALX-270-484-M001
1 mg
40.00 USD
ALX-270-484-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
23
H
13
Cl
2
N
3
O
2
MW:
434.3
CAS NUMBER:
304896-28-4
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC
50
=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Specific Literature References
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease:
T.F. Outeiro, et al.; Science
317
, 516 (2007)
Abstract
Related Products
ALX-270-485
B2
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
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ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.
Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC
50
~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid:
J.T. Sullivan, et al.; Planta Med.
44
, 175 (1982)
Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids:
R. Grazzini, et al.; BBRC
176
, 775 (1991)
Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus:
H. Muroi & I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
;
Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation:
Y. Sun, et al.; FEBS Lett.
580
, 4353 (2006)
Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
:
H. Muroi and I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition
:
R. Paramashivappa, et al.; J. Agric. Food Chem.
50
, 7709 (2002)
Abstract
Further Categories Containing This Product:
Lipoxygenases/Related Products
•
Prostaglandin Synthases/Related Products
•
Antibiotics Other Products
ALX-350-095
Revised 03-Apr-08
Apicidin
SYNONYMS
cyclo
-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation/Transcription
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ALX-350-095-M001
1 mg
50.00 USD
ALX-350-095-M005
5 mg
200.00 USD
Product Specification
FORMULA:
C
34
H
49
N
5
O
6
MW:
623.8
CAS NUMBER:
183506-66-3
SOURCE/HOST:
Isolated from
Fusarium sp.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC.
Product Description
Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest. Stimulates apoptosis of cancer cells. Antiprotozoal.
Product Specific Literature References
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase
:
S.J. Darkin-Rattray, et al.; PNAS
93
, 13143 (1996)
Abstract
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin
:
J.W. Han, et al.; Cancer Res.
60
, 6068 (2000)
Abstract
Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor
:
J.S. Kim, et al.; BBRC
281
, 866 (2001)
Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1
:
S.L. Colletti, et al.; Bioorg. Med. Chem. Lett.
11
, 107 (2001)
Abstract
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2
:
S.L. Colletti, et al.; Bioorg. Med. Chem. Lett.
11
, 113 (2001)
Abstract
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities
:
S.B. Singh, et al.; J. Org. Chem.
67
, 815 (2002)
Abstract
Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells
:
J. Hong, et al.; Cancer Lett.
189
, 197 (2003)
Abstract
Activation of NF-kappaB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis:
Y.K. Kim, et al.; Cell Death Differ.
13
, 2033 (2006)
Abstract
Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells:
T. Ueda, et al.; Int. J. Mol. Med.
19
, 301 (2007)
Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors/Related Products
•
HDAC Inhibitors
•
Parasitic Diseases Other Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Other Anti-infective Agents
•
Natural Products for Cell Cycle Research
ALX-350-129
Revised 04-Dec-07
Aristoforin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-129-M001
1 mg
190.00 USD
Product Specification
FORMULA:
C
37
H
54
O
6
MW:
594.8
CAS NUMBER:
849215-53-8
PURITY:
≥95%
APPEARANCE:
White to yellow oil.
SOLUBILITY:
Soluble in DMSO or 100mM sodium hydrogen carbonate/2% DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Stable and water-soluble derivative of hyperforin (Prod. No.
ALX-350-097
) inducing apoptosis. Antitumor agent. Inhibits sirtuins.
Product Specific Literature References
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent:
M. Gartner, et al.; Chembiochem.
6
, 171 (2005)
Abstract
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2:
C. Gey, et al.; Angew. Chem. Int. Ed. Engl.
46
, 5219 (2007)
Abstract
Related Products
ALX-350-097
Hyperforin . dicyclohexylammonium salt (high purity)
Further Categories Containing This Product:
Sirtuins/Related Products
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Apoptosis Inducers)
ALX-270-485
Revised 07-Apr-08
B2
SYNONYMS
CPNQ
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins/Related Products
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ALX-270-485-MC05
0.5 mg
90.00 USD
Product Specification
FORMULA:
C
20
H
17
ClN
4
O
3
MW:
396.8
CAS NUMBER:
115687-05-3
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and oxygen.
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC
50
=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.
Product Specific Literature References
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases:
R.A. Bodner, et al.; PNAS
103
, 4246 (2006)
Abstract
;
Full Text
Related Products
ALX-270-484
AGK2
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-270-473
Revised 13-Jun-08
BIX 01294
SYNONYMS
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
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ALX-270-473-M002
2 mg
190.00 USD
Product Specification
FORMULA:
C
28
H
38
N
6
O
2
MW:
490.6
CAS NUMBER:
935693-62-2
PURITY:
≥95%
APPEARANCE:
Light brown to brown solid.
SOLUBILITY:
Soluble in DMSO (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Selective and cell permeable inhibitor of G9a histone methyltransferase.
Product Specific Literature References
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase:
S. Kubicek, et al.; Mol. Cell
25
, 473 (2007)
Abstract
ALX-270-411
Revised 01-Apr-08
Butyrolactone 3
SYNONYMS
Gcn5 Inhibitor 1
MB-3
3-Methylene-4-hydroxycarbonyl-5-(1-propyl)-tetrahydrofuran-2-one
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
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ALX-270-411-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
9
H
12
O
4
MW:
184.2
CAS NUMBER:
778649-18-6
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions in DMSO are stable for at least 2 months when stored at -20°C.
Product Description
Racemic. Inhibitor of human histone acetyltransferase Gcn5.
Product Specific Literature References
Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5
:
M. Biel, et al.; Angew. Chem. Int. Ed. Engl.
43
, 3974 (2004)
Abstract
ALX-201-283
Revised 18-Mar-08
CARM1 (human) (recombinant) (His)
SYNONYMS
Coactivator-associated Arginine Methyltransferase 1 (human) (recombinant) (His)
PRMT4 (human) (recombinant) (His)
Protein Arginine N-Methyltransferase 4 (human) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
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ALX-201-283-C002
2 µg
280.00 USD
Product Specification
EC:
EC 2.1.1.125
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~50-100ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression:
M. Covic, et al.; EMBO J.
24
, 85 (2005)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q86X55:
CARM1 (human)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-270-437
Revised 04-Jun-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins/Related Products
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ALX-270-437-M001
1 mg
110.00 USD
Product Specification
FORMULA:
C
13
H
13
ClN
2
O
MW:
248.7
CAS NUMBER:
49843-98-3
PURITY:
≥95%
APPEARANCE:
White to beige powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months when stored at -20°C in the dark.
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC
50
=98nM
in vivo
/ IC
50
=38nM
in vitro
; compared to hSIRT2: IC
50
=19µM and hSIRT3: IC
50
=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC
50
>100µg). Inhibits the deacetylation of p53 (IC
50
=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1:
A.D. Napper, et al.; J. Med. Chem.
48
, 8045 (2005)
Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes:
J.C. Milne, et al.; Nature
450
, 712 (2007)
Abstract
Further Categories Containing This Product:
p53 Other Products
ALX-201-279
Revised 18-Mar-08
CREB Binding Protein (mouse) (recombinant) (His)
SYNONYMS
CBP (mouse) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
CREB & CREB Binding Protein/Related Products
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ALX-201-279-C002
2 µg
280.00 USD
Product Specification
EC:
EC 2.3.1.48
SOURCE/HOST:
Produced in SF21 cells. Fused to a His-tag.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
SPECIFIC ACTIVITY:
~50-100ng are required for standard HAT assay.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store in liquid nitrogen.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P45481:
CREB Binding Protein (mouse)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
Histone Acetyl- & Methyl-Transferases/Related Products
ALX-420-033
Revised 04-Jun-07
CTPB
SYNONYMS
N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-420-033-M001
1 mg
40.00 USD
ALX-420-033-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
31
H
43
ClF
3
NO
2
MW:
554.1
CAS NUMBER:
586976-24-1
PURITY:
≥97% (
1
H-NMR)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent activator of p300 HAT (histone acetyltransferase), but not of PCAF (p300/CBP-associated factor) HAT activities.
General Literature References
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
ALX-201-280
Revised 18-Mar-08
GCN5 (human) (recombinant) (His)
SYNONYMS
GCN5L2 (human) (recombinant) (His)
Histone Acetyltransferase GCN5 (human) (recombinant) (His)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
