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ALX-480-017
Revised 24-Nov-04
Adenosine 5'-O-thiomonophosphate . dilithium salt
SYNONYMS
5'-AMPS . 2 Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-017-M001
1 mg
15.00 USD
ALX-480-017-M005
5 mg
45.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
6
PS . 2Li
MW:
361.3 . 13.9
CAS NUMBER:
93839-85-1
PURITY:
≥97%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Product Description
Substrate and inhibitor of AMP-dependent enzyme systems.
Product Specific Literature References
Adenosine 5'-phosphorothioate. A nucleotide analog that is a substrate, competitive inhibitor, or regulator of some enzymes that interact with adenosine 5'-phosphate
:
A.W. Murray & M.R. Atkinson; Biochemistry
7
, 4023 (1968)
Abstract
ALX-480-066
Revised 06-Jan-09
Adenosine 5'-O-(3-thiotriphosphate) . tetralithium salt
SYNONYMS
ATP-γS . 4Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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Quantity:
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ALX-480-066-M001
1 mg
25.00 USD
ALX-480-066-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
12
P
3
S . 4Li
MW:
520.2 . 27.8
CAS NUMBER:
93889-89-5
PURITY:
≥90%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
HANDLING:
Protect from moisture.
HAZARD:
HARMFUL.
Product Description
ATP analog that can substitute ATP in various kinase reactions. Substrate and inhibitor of ATP-dependent enzyme systems. The resulting thiophosphorylated proteins are resistant to dephosphorylation by protein phosphatases. Increases the activity of Ca
2+
-activated K
+
channels.
Product Specific Literature References
The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate)
:
S. Chrysogelos, et al.; J. Biol. Chem.
258
, 12624 (1983)
Abstract
;
Full Text
Regulation of phosphoinositide breakdown by guanine nucleotides:
I. Litosch & J.N. Fain; Life Sci.
39
, 187 (1986)
Abstract
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation:
J. Chen, et al.; Science
257
, 1261 (1992)
Abstract
Further Categories Containing This Product:
K+ Channel Activators
ALX-480-021
Revised 16-Dec-04
Adenosine 5'-triphosphate . disodium salt
SYNONYMS
ATP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-480-021-G001
1 g
15.00 USD
ALX-480-021-G005
5 g
45.00 USD
Product Specification
FORMULA:
C
10
H
14
N
5
O
13
P
3
. 2Na
MW:
505.2 . 46.0
CAS NUMBER:
51963-61-2
MERCK INDEX:
14:
155
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture. Keep cool and dry.
Further Categories Containing This Product:
Inflammasome
ALX-480-094
Revised 07-Oct-08
ADP-HPD . ammonium salt . dihydrate
SYNONYMS
Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH
4
. 2H
2
O
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
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Format:
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ALX-480-094-C060
60 µg
188.00 USD
Product Specification
FORMULA:
C
15
H
23
N
6
O
12
P
2
. NH
4
. 2H
2
O
MW:
541.3 . 18.0 . 36.0
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white amorphous solid.
SOLUBILITY:
Soluble in water (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.
Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC
50
=120nM) versus ADP-ribose (IC
50
=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
:
J.T. Slama, et al.; J. Med. Chem.
38
, 389 (1995)
Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
:
J.T. Slama, et al.; J. Med. Chem.
38
, 4332 (1995)
Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage
:
S. Vispe, et al.; PNAS
97
, 9886 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
PARG / Related Products
•
DNA Repair Other Products
ALX-270-484
Revised 07-Apr-08
AGK2
SYNONYMS
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Sirtuins / Related Products
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ALX-270-484-M001
1 mg
40.00 USD
ALX-270-484-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
23
H
13
Cl
2
N
3
O
2
MW:
434.3
CAS NUMBER:
304896-28-4
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC
50
=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Specific Literature References
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease:
T.F. Outeiro, et al.; Science
317
, 516 (2007)
Abstract
Related Products
ALX-270-485
B2
Further Categories Containing This Product:
Parkinson's Disease Other Products
ALX-270-285
Revised 20-Oct-08
5-AIQ . hydrochloride
SYNONYMS
5-Aminoisoquinolinone . HCl
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA Repair Other Products
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ALX-270-285-M001
1 mg
50.00 USD
ALX-270-285-M005
5 mg
175.00 USD
Product Specification
FORMULA:
C
9
H
8
N
2
O . HCl
MW:
160.2 . 36.5
PURITY:
≥97%
APPEARANCE:
Beige to brown powder.
SOLUBILITY:
Soluble in water (warm).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
HAZARD:
IRRITANT.
Product Description
Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock:
M.C. McDonald, et al.; Br. J. Pharmacol.
130
, 843 (2000)
Abstract
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury
:
S. Cuzzocrea, et al.; Biochem. Pharmacol.
63
, 293 (2002)
Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation:
H. Kleine, et al.; Mol. Cell
32
, 57 (2008)
Abstract
Further Categories Containing This Product:
PARP Inhibitors
ALX-460-036
Revised 17-Jan-05
Alfacalcidol
SYNONYMS
Hydroxyvitamin D
3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Vitamin D3 & Vitamin D3 Receptor / Related Products
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Format:
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ALX-460-036-M001
1 mg
75.00 USD
Product Specification
FORMULA:
C
27
H
44
O
2
MW:
400.6
CAS NUMBER:
41294-56-8
RTECS:
VS2851000
PURITY:
≥97%
APPEARANCE:
White to off white crystals.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No.
ALX-460-032
)
in vivo
. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
ALX-350-270
Revised 08-Feb-08
α-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
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ALX-350-270-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
39
H
54
N
10
O
14
S
MW:
919.0
CAS NUMBER:
23109-05-9
MERCK INDEX:
14:
373
RTECS:
BD6195000
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specific Literature References
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver:
F. Stirpe & L. Fiume; Biochem. J.
103
, 67P (1967)
Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin:
T.J. Lindell, et al.; Science
170
, 447 (1970)
Abstract
Fifty years of amanitin:
T. Wieland & H. Faulstich; Experientia
47
, 1189 (1991), (Review)
Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II:
X.Q. Gong, et al.; J. Biol. Chem.
279
, 27422 (2004)
Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
RNA Polymerases / Related Products
•
Protein Synthesis Other Products
ALX-350-271
Revised 08-Oct-07
β-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
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ALX-350-271-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
39
H
53
N
9
O
15
S
MW:
920.0
CAS NUMBER:
21150-22-1
MERCK INDEX:
14:
373
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
FORMULATION:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Biological activity like α-amanitin (Prod. No.
ALX-350-270
), but contains a carboxy group which is useful for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
RNA Polymerases / Related Products
•
Protein Synthesis Other Products
ALX-350-272
Revised 17-Dec-07
γ-Amanitin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-272-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
39
H
54
N
10
O
13
S
MW:
903.0
CAS NUMBER:
13567-11-8; 21150-23-2
MERCK INDEX:
14:
373
SOURCE/HOST:
Isolated from
Amanita phalloides
mushrooms.
PURITY:
≥90%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Biological activity like α-amanitin (Prod. No.
ALX-350-270
).
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products
•
RNA Polymerases / Related Products
•
Protein Synthesis Other Products
ALX-380-283
Revised 21-May-08
7-Amino-actinomycin D
