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PARP Inhibitors
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP] / Related Products > PARP Inhibitors
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ALX-270-044 Revised 25-Sep-06
3-Aminobenzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-044-G001   1 g 50.00 USD Add To Cart
ALX-270-044-G005   5 g 190.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O
MW: 136.2
CAS NUMBER: 3544-24-9
RTECS: CU8992000
PURITY: ≥97%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. Apoptosis inhibitor.
Product Specific Literature References
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC 179, 1225 (1991) Abstract
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994) Abstract
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994) Abstract
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995) Abstract
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995) Abstract
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-174 Revised 03-Apr-06
Benzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-174-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C7H7NO
MW: 121.1
CAS NUMBER: 55-21-0
MERCK INDEX: 14: 1060
RTECS: CU8700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Neuroprotectant.
Product Specific Literature References
Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells: H.N. Jayaram, et al.; BBRC 186, 1600 (1992) Abstract
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) Abstract
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DNA Repair Other Products
 
 
ALX-270-221 Revised 23-Jul-07
DPQ
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SYNONYMS 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-221-M001   1 mg 52.00 USD Add To Cart
ALX-270-221-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C18H26N2O2
MW: 302.4
CAS NUMBER: 129075-73-6
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown solid.
SOLUBILITY: Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 1 month when stored at -20°C.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.
Product Specific Literature References
Dihydroisoquinolines: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase: M.J. Suto, et al.; Anticancer Drug Des. 6, 107 (1991) Abstract
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia: M.J.L. Eliasson, et al.; Nat. Med. 3, 1089 (1997) Abstract
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats: H. Takahashi, et al.; J. Cereb. Blood Flow Metab. 17, 1137 (1997) Abstract
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS 19, 287 (1998), (Review) Abstract
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res. 829, 46 (1999) Abstract; Full Text
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ. 8, 921 (2001) Abstract
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab. 22, 697 (2002) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-250 Revised 18-Jan-06
4-Amino-1,8-naphthalimide
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SYNONYMS 4-ANI
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-250-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C12H8N2O2
MW: 212.2
CAS NUMBER: 1742-95-6
RTECS: DE4081000
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for 3 months when stored at –20°C.
HAZARD: IRRITANT.

Product Description
Potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=0.18µM). About 1000-fold more potent than 3-aminobenzamide (Prod. No. ALX-270-044).
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion: J. Radons, et al.; BBRC 199, 1270 (1994) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle: C. Thiemermann, et al.; PNAS 94, 679 (1997) Abstract; Full Text
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers: J. Bowes & C. Thiemermann; Br. J. Pharmacol. 124, 1254 (1998) Abstract
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer: A. Schlicker, et al.; Int. J. Radiat. Biol. 75, 91 (1999) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-251 Revised 02-Jun-06
6(5H)-Phenanthridinone
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-251-M010   10 mg 15.00 USD Add To Cart
Product Specification
FORMULA: C13H9NO
MW: 195.2
CAS NUMBER: 1015-89-0
RTECS: SG0370000
PURITY: ≥95%
APPEARANCE: Light brown solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Poly(ADP-ribose)polymerase (PARP) inhibitor.
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor: D. Weltin, et al.; Int. J. Immunopharmacol. 17, 265 (1995) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis: D. Weltin, et al.; Biochem. Pharmacol. 51, 1123 (1996) Abstract
Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells: D. Weltin, et al.; Int. J. Radiat. Biol. 72, 685 (1997) Abstract
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase: M.R. Cookson, et al.; J. Neurochem. 70, 501 (1998) Abstract
Effects of PARP inhibition on drug and Fas-induced apoptosis in leukaemic cells: D.S. Richardson, et al.; Adv. Exp. Med. Biol. 457, 267 (1999) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-278 Revised 01-Jul-08
5-Iodo-6-amino-1,2-benzopyrone
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SYNONYMS INH2BP
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-278-M001   1 mg 25.00 USD Add To Cart
ALX-270-278-M005   5 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C9H6INO2
MW: 287.1
CAS NUMBER: 137881-27-7
PURITY: ≥98%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase: P.I. Bauer, et al.; Biochimie 77, 374 (1995) Abstract
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development: M. Endres, et al.; Eur. J. Pharmacol. 351, 377 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells: M. Kennedy, et al.; Gastroenterology 114, 510 (1998) Abstract
Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock: C. Szabó, et al.; Shock 9, 341 (1998) Abstract
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase: C. Szabó, et al.; PNAS 95, 3867 (1998) Abstract; Full Text
Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation: L. Virág, et al.; Free Radic. Biol. Med. 25, 1075 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death: L. Virág, et al.; J. Immunol. 161, 3753 (1998) Abstract; Full Text
Novel roles of nitric oxide in hemorrhagic shock: C. Szabo & T.R. Billiar; Shock 12, 1 (1999) Abstract
Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME): E. Kirsten & E. Kun; Int. J. Mol. Med. 5, 279 (2000) Abstract
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis: G.S. Scott, et al.; J. Neuroimmunol. 117, 78 (2001) Abstract
Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes: J.G. Mabley, et al.; Br. J. Pharmacol. 133, 909 (2001) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-279 Revised 01-Jun-06
4-Hydroxyquinazoline
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SYNONYMS 4-Quinazolinol
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-279-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C8H6N2O
MW: 146.2
CAS NUMBER: 491-36-1
RTECS: VA2300000
PURITY: ≥98%
APPEARANCE: White to grey solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-285 Revised 11-Aug-06
5-AIQ . hydrochloride
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SYNONYMS 5-Aminoisoquinolinone . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-270-285-M001   1 mg 50.00 USD Add To Cart
ALX-270-285-M005   5 mg 175.00 USD Add To Cart
Product Specification
FORMULA: C9H8N2O . HCl
MW: 160.2 . 36.5
PURITY: ≥97%
APPEARANCE: Beige to brown powder.
SOLUBILITY: Soluble in water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: IRRITANT.

Product Description
Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 130, 843 (2000) Abstract
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury: S. Cuzzocrea, et al.; Biochem. Pharmacol. 63, 293 (2002) Abstract
Further Categories Containing This Product:
PARP Inhibitors
 
 
ALX-270-289 Revised 25-Jun-08
PJ-34
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SYNONYMS N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-289-M001   1 mg 50.00 USD Add To Cart
ALX-270-289-M005   5 mg 125.00 USD Add To Cart
ALX-270-289-M025   25 mg 375.00 USD Add To Cart
Product Specification
FORMULA: C17H17N3O2 . HCl
MW: 295.2 . 36.5
PURITY: ≥98% (NMR)
APPEARANCE: White to light brown powder.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for 2 years after receipt when stored at +4C°. Stock solutions are stable for 3 weeks when stored at room temperature.
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50=20nM compared to EC50=200µM of the prototypical PARP inhibitor 3-aminobenzamide (Prod. No. ALX-270-044)). Inhibits peroxynitrite (Prod. No. ALX-400-036)-induced cell necrosis (EC50=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.
Product Specific Literature References
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke: G.E. Abdelkarim, et al.; Int. J. Mol. Med. 7, 255 (2001) Abstract
Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes: P. Bai, et al.; Free Radic. Biol. Med. 31, 1616 (2001) Abstract
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation: F. Garcia Soriano, et al.; Nat. Med. 7, 108 (2001) Abstract
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase: J.G. Mabley, et al.; Inflamm. Res. 50, 561 (2001) Abstract
Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor: R. Faro, et al.; Ann. Thorac. Surg. 73, 575 (2002) Abstract
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents: P. Jagtap, et al.; Crit. Care Med. 30, 1071 (2002) Abstract
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging: P. Pacher, et al.; Int. J. Mol. Med. 9, 659 (2002) Abstract
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure: P. Pacher, et al.; J. Am. Coll. Cardiol. 40, 1006 (2002) Abstract
Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia: Z. Ivanyi, et al.; Shock 19, 415 (2003) Abstract; Full Text
General Literature References
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors: L. Virag and C. Szabo; Pharmacol. Rev. 54, 375 (2002), (Review) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Non-apoptotic Cell Death / Necrosis
 
 
ALX-270-365 Revised 01-Jul-08