ALEXIS Biochemicals: Polyclonal Antibody to XRCC1 (human)

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ALX-210-304

Revised 27-Dec-06

Polyclonal Antibody to XRCC1 (human)
SYNONYMS	anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	XRCC Proteins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-304-R050		50 µl	235.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Contains 0.1% sodium azide.
IMMUNOGEN:	Recombinant human XRCC1 (X-ray repair cross-complementing group 1).
SPECIFICITY:	Recognizes human XRCC1.
APPLICATION:	ELISA Immunocytochemistry Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1: V. Schreiber, et al.; J. Biol. Chem. 277, 23028 (2002) Abstract; Full Text

General Information

XRCC1 (X-ray repair cross-complementing 1) exerts multiple functions in repairing base damage and frank single strand breaks. These functions include stabilizing DNA ligase 3, bridging the steps in base excision repair (BER) through protein interactions (via its BRCT motif), directly detecting breaks produced by chemical or enzymatic action, coordinating the binding and polymerase activity of DNA polymerase β, promoting an S phase-specific mode of single strand break repair. XRCC1 is specifically associated with poly(ADP-ribose) polymerase (PARP) and negatively regulates its activity following DNA damage.

Related Products

ALX-210-539

Polyclonal Antibody to XRCC1 (human)

Further Categories Containing This Product:

PARP Other Products • Polyclonal Antibodies

ALX-210-539

Revised 27-Oct-06

Polyclonal Antibody to XRCC1 (human)
SYNONYMS	anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	XRCC Proteins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-539-R100		100 µl	250.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN:	Recombinant human XRCC1 (X-ray repair cross-complementing group 1) fused to a His-tag.
SPECIFICITY:	Recognizes human XRCC1.
APPLICATION:	Immunocytochemistry (1:1’000) Immunoprecipitation (1:200) Western Blot (1:2’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least one year when stored at +4°C.

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Product Specific Literature References

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage: N. Levy, et al.; Nucl. Acids Res. 34, 32 (2006) Full Text