ALEXIS Biochemicals: Polyclonal Antibody to SRC-1

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ALX-804-283

Revised 10-Mar-08

Monoclonal Antibody to AIB1 (human) (AX15.3)
SYNONYMS	anti-Amplified in Breast Cancer 1 (human) MAb (AX15.3) anti-SRC-3 (human) MAb (AX15.3) anti-Steroid Receptor Coactivator-3 (human) MAb (AX15.3) anti-NCOA3 (human) MAb (AX15.3) anti-Nuclear Receptor Coactivator 3 (human) MAb (AX15.3)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Nuclear Receptor Coactivators / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-283-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	AX15.3
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. Purified antibody in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Recombinant human AIB1 (amplified in breast cancer 1) (aa 605-1294).
SPECIFICITY:	Recognizes human AIB1. Detects a band of ~155kDa by Western blot.
APPLICATION:	Immunoprecipitation Western Blot (2µg/ml) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Production and characterization of monoclonal antibodies to the steroid receptor coactivator AIB1: D.O. Azorsa, et al.; Hybridoma 18, 28 (1999) Abstract

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Monoclonal Antibodies

ALX-804-191

Revised 05-May-08

Monoclonal Antibody to SRC-1 (1135/H4)
SYNONYMS	anti-Steroid Receptor Coactivator-1 MAb (1135/H4) anti-NCOA1 MAb (1135/H4) anti-Nuclear Receptor Coactivator 1 MAb (1135/H4)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Nuclear Receptor Coactivators / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-191-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Monkey
CLONE:	1135/H4
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 477-947 of human SRC-1 (steroid receptor coactivator-1).
SPECIFICITY:	Recognizes human, mouse and monkey SRC-1. Detects a band of ~165kDa (and an unspecific band of 30-40kDa) by Western blot.
APPLICATION:	Immunohistochemistry (paraffin sections (1:200)) Immunoprecipitation Western Blot (1:2’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Monoclonal Antibodies

ALX-210-255

Revised 25-Sep-06

Polyclonal Antibody to AIB1 (human)
SYNONYMS	anti-Amplified in Breast Cancer 1 (human) PAb anti-SRC-3 (human) PAb anti-Steroid Receptor Coactivator-3 (human) PAb anti-NCOA3 (human) PAb anti-Nuclear Receptor Coactivator 3 (human) PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Nuclear Receptor Coactivators / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-255-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 3-15 (G³LGENLDPLASDS¹⁵C) of human AIB1 (amplified in breast cancer 1).
SPECIFICITY:	Recognizes human AIB1. Detects a band of ~155kDa by Western blot.
APPLICATION:	Western Blot (2µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-151-034.

General Information

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. AIB1 (Amplified In Breast Cancer-1) is a member of a growing family of transcriptional coactivator proteins which includes SRC-1 and GRIP1.
AIB1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, progesterone, and peroxisome proliferator activated receptors. AIB1 also interacts with the transcriptional integrators CREB binding protein (CBP) and p300.

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Polyclonal Antibodies

ALX-210-286

Revised 15-Jun-06

Polyclonal Antibody to Glucocorticoid Receptor Interacting Protein 1
SYNONYMS	anti-GRIP1 PAb anti-TIF2 PAb anti-Transcriptional Intermediatory Factor 2 PAb anti-SRC-2 PAb anti-Steroid Receptor Coactivator-2 PAb anti-NCOA2 PAb anti-Nuclear Receptor Coactivator 2 PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Glucocorticoids & Glucocorticoid Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-286-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Others
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 206-217 (P²⁰⁶LPDSEEEGHDS²¹⁷C) of human GRIP1 (glucocorticoid receptor interacting protein-1).
SPECIFICITY:	Recognizes human and hamster GRIP1.
APPLICATION:	Immunocytochemistry (1:1’000) Immunohistochemistry (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-157-019.

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Product Description

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. GRIP1 (Glucocorticoid Receptor Interacting Protein-1), or TIF2 (Transcription Intermediary Factor 2), is a member of a growing family of transcriptional coactivator proteins which includes SRC-1 and AIB1. GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.

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Nuclear Receptor Coactivators / Related Products • Polyclonal Antibodies

ALX-210-283

Revised 06-Apr-06

Polyclonal Antibody to SRC-1
SYNONYMS	anti-Steroid Receptor Coactivator-1 PAb anti-NCOA1 PAb anti-Nuclear Receptor Coactivator 1 PAb
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Nuclear Receptor Coactivators / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-283-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml.
PURITY DETAIL:	Epitope-affinity purified IgG.
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 8-24 (S⁸SDPANPDSHKRK GSPC²⁴) of human SRC-1 (steroid receptor coactivator-1).
SPECIFICITY:	Recognizes human and mouse SRC-1. Detects a band of ~165kDa and an unspecific band of ~40kDa by Western blot.
APPLICATION:	Immunocytochemistry (1µg/ml) Immunohistochemistry (frozen sections (1µg/ml)) Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-167-020.

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Product Description

Further Categories Containing This Product:

Polyclonal Antibodies

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