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ALX-215-030
Revised 12-Feb-07
Polyclonal Antibody to 14-3-3
SYNONYMS
anti-pan-14-3-3 PAb
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-030-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Mixture of 14-3-3 isoforms isolated from sheep brain.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3. Detects a band of ~28kDa by Western blot.
APPLICATION:
Immunohistochemistry
Immunoprecipitation
Western Blot (1:2000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo:
M. Chaudhri, et al.; BBRC
300
, 679 (2003)
Abstract
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Neurofibrillary tangles of Alzheimer’s disease brains contain 14-3-3 proteins:
R. Layfield, et al.; Neurosci. Lett.
209
, 57 (1996)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-021
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3β
SYNONYMS
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-Protein 1054 PAb
anti-14-3-3α PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-021-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-8 (T
1
MDKSELV
8
C) of 14-3-3β.
SPECIFICITY:
Recognizes human, mouse, rat, sheep and bovine 14-3-3β.
APPLICATION:
ELISA
Immunohistochemistry (1:600)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-026
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3β/ζ (phosphorylated) (pSer185)
SYNONYMS
anti-KCIP-1 (phosphorylated) (pSer
185
) PAb
anti-Protein Kinase C Inhibitor Protein 1 (phosphorylated) (pSer
185
) PAb
anti-Protein 1054 (phosphorylated) (pSer
185
) PAb
anti-14-3-3α/δ (phosphorylated) (pSer
185
) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-026-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From sheep.
PURITY DETAIL:
Affinity-purified.
FORMULATION:
Liquid. Contains no preservatives.
IMMUNOGEN:
Synthetic phosphorylated peptide corresponding to aa 181-190 (E
181
ILNpSPEKAC
190
) of 14-3-3β and aa 180-189 of 14-3-3ζ.
SPECIFICITY:
Recognizes human, mouse, rat, sheep and bovine 14-3-3β and 14-3-3ζ.
APPLICATION:
Western Blot (1:300)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Polyclonal Antibodies
ALX-215-022
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3ε (CT)
SYNONYMS
anti-KCIP-1 PAb (CT)
anti-Protein Kinase C Inhibitor Protein 1 PAb (CT)
anti-14-3-3E PAb (CT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-022-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 239-255 (CG
239
EEQNKEALQDVEDENQ
255
) of 14-3-3ε.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3ε.
APPLICATION:
ELISA
Immunohistochemistry
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-023
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3η
SYNONYMS
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-Protein AS1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-023-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-11 (G
1
DREQLLQRAR
11
C) of 14-3-3η.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3η.
APPLICATION:
Immunohistochemistry (1:3200)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-024
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3γ
SYNONYMS
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-024-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-10 (V
1
DREQLVQKA
10
C) of 14-3-3γ.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3γ.
APPLICATION:
ELISA
Immunohistochemistry (1:800)
Western Blot (1:6’000-1:12’000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-027
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3σ
SYNONYMS
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-Stratifin PAb
anti-SFN PAb
anti-Epithelial Cell Marker Protein 1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-027-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-10 (M
1
ERASLIQKA
10
C) of 14-3-3σ.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3σ.
APPLICATION:
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo:
M.L. Henriksson, et al.; Eur. J. Biochem.
269
, 4921 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-245
Revised 21-Nov-06
Polyclonal Antibody to Ah Receptor Nuclear Translocator 3
SYNONYMS
anti-ARNT3 PAb
anti-BMAL1 PAb
anti-Brain & Muscle ARNT-like 1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-245-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 582-594 (CD
582
MIDNDQG
SSSPS
594
) of mouse ARNT3 (Ah receptor nuclear translocator 3).
SPECIFICITY:
Recognizes human and hamster ARNT3.
APPLICATION:
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-152-023
.
General Information
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK-BMAL1 has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian the timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Circadian Transcriptional Regulators / Related Products
•
Polyclonal Antibodies
ALX-210-243
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (NT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-243-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.0mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 11-30 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse, rat and hamster CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Immunohistochemistry
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-031
.
Product Description
Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of
Drosophila per
. PER, in concert with the product of the mammalian
timeless
gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-244
Revised 20-Oct-04
Polyclonal Antibody to CLOCK (mouse) (CT)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Circadian Transcriptional Regulators / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-244-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
100µg of epitope affinity purified rabbit IgG (1.9mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-411 of mouse CLOCK.
SPECIFICITY:
Recognizes mouse CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:
Western Blot (1:200)