Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
>
Kinases / Related Products
> Tyrosine Kinases / Related Products
Focal Adhesion Kinase [FAK] / Related Products
Janus Kinases [JAKs] / Related Products
Kinases in T Cell Signal Transduction / Related Products
Receptor Tyrosine Kinases / Related Products
Src Family Kinases / Related Products
Tyrosine Kinase Inhibitors
Tyrphostins
Tyrosine Kinases Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
120-140
of 170
Page 7
of 9
Select Page:
<<
1
2
3
4
5
6
7
8
9
>>
ALX-380-219
Revised 08-Apr-08
Reveromycin D
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Cell Cycle Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-219-MC25
0.25 mg
320.00 USD
Product Specification
FORMULA:
C
37
H
54
O
11
MW:
674.8
CAS NUMBER:
144860-70-8
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5344.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in ethyl acetate, 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Unstable in acidic conditions.
Product Description
Antibiotic. Minor component of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). More active than its straight chain analog reveromycin C (Prod. No.
ALX-380-218
).
Product Specific Literature References
Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1409 (1992)
Abstract
Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities:
H. Takahashi, et al.; J. Antibiot. (Tokyo)
45
, 1414 (1992)
Abstract
Further Categories Containing This Product:
Bone Metabolism Other Products
•
EGFR Kinase Inhibitors
•
Antibiotics - Antifungal
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-166-002
Revised 07-Feb-05
R-R-SRC-Peptide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-166-002-M001
1 mg
80.00 USD
ALX-166-002-M005
5 mg
350.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly-OH
FORMULA:
C
64
H
106
N
22
O
21
MW:
1519.7
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein tyrosine kinases. The peptide sequence corresponds to the tyrosine phosphorylation site in the
Rous sarcoma
virus (RSV)-encoded transforming protein pp60
v-src
.
In vitro
tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line:
J.E. Casnellie, et al.; PNAS
79
, 282 (1982)
Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function:
L.J. Pike, et al.; J. Biol. Chem.
261
, 3782 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-270-330
Revised 14-Jul-05
SU 4984
SYNONYMS
3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-330-M001
1 mg
120.00 USD
Product Specification
FORMULA:
C
20
H
19
N
3
O
2
MW:
333.4
PURITY:
≥98%
APPEARANCE:
Orange to red crystalline solid.
SOLUBILITY:
Soluble in DMSO or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1). Inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC
50
=20-4µM) and the tyrosine phosphorylation of the PDGF receptor and the insulin receptor. Does not inhibit the kinase activity of the EGF receptor.
Product Specific Literature References
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
:
M. Mohammadi, et al.; Science
276
, 955 (1997)
Abstract
ALX-380-221
Revised 14-Nov-07
Sulochrin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-221-M001
1 mg
195.00 USD
Product Specification
FORMULA:
C
17
H
16
O
7
MW:
332.3
CAS NUMBER:
519-57-3
SOURCE/HOST:
Isolated from
Aspergillus terreus
MST-FP1370.
PURITY:
≥99% (HPLC)
APPEARANCE:
Pale yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fungal metabolite found in a number of
Aspergillus
and
Penicillium
sp. Inhibitor of vascular endothelial growth factor (VEGF). Antiangiogenic agent. Inhibits eosinophil activation and chemotaxis.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol:
A. Mahmoodian and C.E. Stickings; Biochem. J.
92
, 369 (1964)
Abstract
;
Full Text
Sulochrin inhibits eosinophil degranulation:
H. Ohashi, et al.; J. Antibiot. (Tokyo)
50
, 972 (1997)
Abstract
Sulochrin inhibits eosinophil activation and chemotaxis:
H. Ohashi, et al.; Inflamm. Res.
47
, 409 (1998)
Abstract
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs:
H.J. Lee, et al.; J. Antibiot. (Tokyo)
55
, 552 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
VEGFs & VEGF-Rs Other Products
•
Antibiotics - Immunomodulators
ALX-168-004
Revised 02-Apr-03
H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Src Family Kinases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-168-004-M001
1 mg
90.00 USD
ALX-168-004-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
44
H
60
N
8
O
11
MW:
877.0
PURITY:
97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide selected from a random combinatorial peptide library. Specific and efficient substrate for the
Src
-family protein tyrosine kinase than cdc2 (6-20).
Product Specific Literature References
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases:
K.S. Lam, et al.; Int. J. Peptide Protein Res.
45
, 587 (1995)
Abstract
Further Categories Containing This Product:
Peptides
ALX-270-127
Revised 07-Dec-04
Tyrphostin AG 9
SYNONYMS
Tyrphostin A1
(4-Methoxybenzylidene)malononitrile
α-Cyano-(4-methoxy)cinnamonitrile)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-127-M005
5 mg
35.00 USD
ALX-270-127-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
11
H
8
N
2
O
MW:
184.2
CAS NUMBER:
2826-26-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
ALX-270-166
Revised 11-Dec-04
Tyrphostin AG 10
SYNONYMS
Tyrphostin A8
4-Hydroxybenzylidenemalononitrile
α-Cyano-(4-hydroxy)-cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-166-M005
5 mg
35.00 USD
ALX-270-166-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
MW:
170.2
CAS NUMBER:
3785-90-8
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrosine phosphorylation is an obligatory event in IL-2 secretion [published erratum appears in J Immunol 1991 May 1;146(9):3260]:
J.B. Stanley, et al.; J. Immunol.
145
, 2189 (1990)
Abstract
Inhibition of GTP-utilizing enzymes by tyrphostins:
G. Wolbring, et al.; J. Biol. Chem.
269
, 22470 (1994)
Abstract
;
Full Text
ALX-270-183
Revised 28-Oct-08
Tyrphostin AG 17
SYNONYMS
Tyrphostin A9
Tyrphostin RG 50872
(3,5-Di-t-butyl-4-hydroxybenzylidene)-malononitrile
α-Cyano-(3,5-di-tert.butyl-4-hydroxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-183-M005
5 mg
40.00 USD
ALX-270-183-M025
25 mg
105.00 USD
Product Specification
FORMULA:
C
18
H
22
N
2
O
MW:
282.4
CAS NUMBER:
10537-47-0
RTECS:
OO3737000
PURITY:
≥98%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
HAZARD:
TOXIC.
Product Specific Literature References
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells:
G.E. Bilder, et al.; Am. J. Physiol.
260
, C721 (1991)
Abstract
Tyrphostins as molecular tools and potential antiproliferative drugs:
A. Levitzki and C. Gilon; TIPS
12
, 171 (1991), (Review)
Abstract
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria:
A.M. Burger, et al.; Cancer Res.
55
, 2794 (1995)
Abstract
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2:
G.A. Palumbo, et al.; Cancer Res.
57
, 2434 (1997)
Abstract
Chemosensitization of glioblastoma cells to bis-dichloroethyl- nitrosourea with tyrphostin AG17:
B.C. Liang & E. Ullyatt; Clin. Cancer Res.
4
, 773 (1998)
Abstract
ALX-270-129
Revised 18-Jan-08
Tyrphostin AG 18
SYNONYMS
Tyrphostin A23
Tyrphostin RG 50858
Tyrphostin RG 50810
(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-129-M005
5 mg
35.00 USD
ALX-270-129-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
2
MW:
186.2
CAS NUMBER:
118409-57-7
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation:
R.M. Lyall, et al.; J. Biol. Chem.
264
, 14503 (1989)
Abstract
;
Full Text
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini:
R.D. Duan & J.A. Williams; Am. J. Physiol.
267
, G401 (1994)
Abstract
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex:
S. Kapas, et al.; Biochem. J.
305
, 433 (1995)
Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein- tyrosine kinase:
R. Seger, et al.; J. Biol. Chem.
270
, 28325 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-222
Revised 13-Jun-03
Tyrphostin AG 30
SYNONYMS
Tyrphostin A36
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-222-M005
5 mg
65.00 USD
ALX-270-222-M010
10 mg
105.00 USD
Product Specification
FORMULA:
C
10
H
7
NO
4
MW:
205.2
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or acetone; insoluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-224
Revised 13-Jun-03
Tyrphostin AG 34
SYNONYMS
Tyrphostin A24
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-224-M001
1 mg
35.00 USD
ALX-270-224-M005
5 mg
100.00 USD
Product Specification
FORMULA:
C
11
H
8
N
2
O
3
MW:
216.2
PURITY:
≥98%
APPEARANCE:
Orange to brown solid.
SOLUBILITY:
Soluble in DMSO or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-135
Revised 08-Dec-04
Tyrphostin AG 43
