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Items 17 of 17
ALX-450-013
Revised 22-Feb-08
BAPTA . tetrapotassium salt
SYNONYMS
1,2-
bis
(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid . 4K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calcium Chelators/Caged Calcium Chelators
Ordering Information
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ALX-450-013-G001
1 g
98.00 USD
Product Specification
FORMULA:
C
22
H
20
N
2
O
10
. 4K
MW:
472.4 . 156.4
CAS NUMBER:
73630-08-7
PURITY:
≥97% (as anhydride)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
Product Description
Highly selective Ca
2+
chelating agent.
Product Specific Literature References
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures:
R.Y. Tsien; Biochemistry
19
, 2396 (1980)
Abstract
Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid:
H. Kijima & T. Tanabe; J. Physiol.
403
, 135 (1988)
Abstract
Transmitter release at frog end-plate loaded with a Ca2+-chelator, BAPTA: hypertonicity and erythrosin B augment the release independently of internal Ca2+:
N. Tanabe & H. Kijima; Neurosci. Lett.
92
, 52 (1988)
Abstract
Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro:
M. Tymianski, et al.; J. Neurophysiol.
72
, 1973 (1994)
Abstract
Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro:
L. Li, et al.; J. Cell Physiol.
163
, 105 (1995)
Abstract
Further Categories Containing This Product:
Dyes/Stains/Fluorescent Probes/Fluorescent Labels
•
Nuclear Envelope & Nuclear Transport
ALX-450-014
Revised 22-Feb-08
BAPTA/AM
SYNONYMS
1,2-
bis
(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
tetrakis
(acetoxymethyl) ester
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calcium Chelators/Caged Calcium Chelators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-450-014-M010
10 mg
48.00 USD
ALX-450-014-M050
50 mg
195.00 USD
Product Specification
FORMULA:
C
34
H
40
N
2
O
18
MW:
764.7
CAS NUMBER:
126150-97-8
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Packaged under inert gas. Protect from light and moisture.
HAZARD:
IRRITANT.
IDENTITY:
Determined by
1
H-NMR.
Product Description
Cell permeable acetoxymethyl ester derivative of BAPTA (Prod. No.
ALX-450-013
). Useful for controlling intracellular Ca
2+
concentration. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
Product Specific Literature References
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator:
V.L. Lew, et al.; Nature
298
, 478 (1982)
Abstract
BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages:
P. Dieter, et al.; Biol. Chem. Hoppe-Seyler
374
, 171 (1993)
Abstract
Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation:
G.E. Billman; Am. J. Physiol.
265
, H1529 (1993)
Abstract
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin:
S. Jiang, et al.; Exp. Cell. Res.
212
, 84 (1994)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
•
Nuclear Envelope & Nuclear Transport
ALX-380-101
Revised 12-Oct-07
Leptomycin A
SYNONYMS
ATS1287 A
LMA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-380-101-C050
50 µg
75.00 USD
ALX-380-101-C100
100 µg
120.00 USD
Product Specification
FORMULA:
C
32
H
46
O
6
MW:
526.7
CAS NUMBER:
87081-36-5
SOURCE/HOST:
Isolated from
Streptomyces sp
.
CONCENTRATION:
0.1mg/ml
PURITY:
≥95% (HPLC)
APPEARANCE:
Liquid. In 100% ethanol.
SOLUBILITY:
Soluble in methanol or 100% ethanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
HAZARD:
FLAMMABLE. TOXIC.
Product Description
Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA.
Product Specific Literature References
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization:
T. Hamamoto, et al.; J Antibiot (Tokyo)
36
, 639 (1983)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport"
.
Further Categories Containing This Product:
Antibiotics for Cell Cycle Research
•
Nuclear Envelope & Nuclear Transport
ALX-380-100
Revised 14-Mar-08
Leptomycin B
SYNONYMS
LMB
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
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ALX-380-100-C100
100 µg
95.00 USD
Product Specification
FORMULA:
C
33
H
48
O
6
MW:
540.7
CAS NUMBER:
87081-35-4
SOURCE/HOST:
Isolated from
Streptomyces sp
.
CONCENTRATION:
0.2mg/ml
PURITY:
≥98% (HPLC)
FORMULATION:
Liquid. In 100% ethanol.
SOLUBILITY:
Soluble in methanol or 100% ethanol; insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
HAZARD:
TOXIC. FLAMMABLE.
Product Description
Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA.
Product Specific Literature References
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization:
T. Hamamoto, et al.; J. Antibiot. (Tokyo)
36
, 639 (1983)
Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms:
T. Meissner, et al.; FEBS Lett.
576
, 27 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport"
.
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
Nuclear Envelope & Nuclear Transport
•
Antibiotics for Cell Cycle Research
ALX-850-313
Revised 14-Feb-07
Leptomycin Set I
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
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ALX-850-313-KI01
1 Set
170.00 USD
Product Specification
KIT/SET CONTAINS:
1x100µg of Leptomycin A (Prod. No.
ALX-380-101
)
1x100µg of Leptomycin B (Prod. No.
ALX-380-100
)
PURITY:
≥95% (HPLC)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport"
.
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
Nuclear Envelope & Nuclear Transport
•
Antibiotics for Cell Cycle Research
ALX-850-316
Revised 01-Nov-07
Leptomycin Set II
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-316-KI01
1 Set
290.00 USD
Product Specification
KIT/SET CONTAINS:
1x100µg of Leptomycin A (Prod. No.
ALX-380-101
)
1x100µg of Leptomycin B (Prod. No.
ALX-380-100
)
1x5µg of Ratjadone C (native) (Prod. No.
ALX-270-369
)
PURITY:
≥95% (HPLC)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport"
.
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
Nuclear Envelope & Nuclear Transport
•
Antibiotics for Cell Cycle Research
ALX-803-040
Revised 11-Jan-05
Monoclonal Antibody to Lamina-associated Polypeptide 1 (rat) (RL13)
SYNONYMS
anti-LAP1 (rat) MAb (RL13)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Envelope & Nuclear Transport
Ordering Information
Product Numbers:
Format:
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ALX-803-040-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE:
RL13
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Purified antibody in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified pore-complex lamina fraction from rat liver nuclear envelopes.
SPECIFICITY:
Recognizes rat LAP (lamina-associated polypeptide) 1A, 1B and 1C. Does not cross-react with LAP2.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-803-041
Revised 09-Jul-07
Monoclonal Antibody to Lamina-Associated Polypeptide 2 (rat) (RL29)
SYNONYMS
anti-LAP2 (rat) MAb (RL29)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Envelope & Nuclear Transport
Ordering Information
Product Numbers:
Format:
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ALX-803-041-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE:
RL29
ISOTYPE:
Hamster IgG
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified pore-complex lamina fraction from rat liver nuclear envelopes.
SPECIFICITY:
Recognizes rat LAP2 (lamina-associated polypeptide 2). Detects a band of ~53kDa by Western blot. Does not cross-react with LAP 1A, 1B or 1C.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-113
Revised 30-Jan-06
Monoclonal Antibody to Nuclear Pore Glycoprotein (O-linked) (RL1)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Envelope & Nuclear Transport
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-804-113-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Others
CLONE:
RL1
ISOTYPE:
Mouse IgM
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified pore complex lamina fraction from rat liver nuclear envelopes.
SPECIFICITY:
Recognizes rat, amphibian and yeast nuclear pore O-linked glycoprotein.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-025
Revised 24-Oct-06
Monoclonal Antibody to Nuclear Transport Factor p97 (3E9)
SYNONYMS
anti-NTF97 MAb (3E9)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Envelope & Nuclear Transport
Ordering Information
Product Numbers:
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ALX-804-025-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Pig
CLONE:
3E9
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified bovine NTF97 (nuclear transport factor p97).
SPECIFICITY:
Recognizes human, mouse, rat, dog and pig NTF97.
APPLICATION:
Immunocytochemistry (1:1'000)
Immunoprecipitation
Western Blot (1:5'000)
Functional Application (inhibits import of NLS-containing proteins in permeabilized cells)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Novel nuclear herniations induced by nuclear localization of a viral protein:
C.C. Hoyt, et al.; J. Virol.
78
, 6360 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-275
Revised 15-Jul-08
Monoclonal Antibody to Nucleoporin p62 (rat) (RL31)
SYNONYMS
anti-Nuclear Pore Glycoprotein p62 (rat) (RL31) MAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Nuclear Envelope & Nuclear Transport
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-275-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE:
RL31
ISOTYPE:
Hamster IgG
PURITY DETAIL:
Protein G-affinity purfied.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified
O
-linked glycoprotein-enriched fraction from rat liver nuclear envelopes.
SPECIFICITY:
Recognizes rat nucleoporin p62
O
-linked glycoprotein in the p62 complex. Detects a band of ~62kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:50)
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex:
T. Guan, et al.; Mol. Biol. Cell
6
, 1591 (1995)
Abstract
Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate genomic union during mammalian fertilization:
C. Payne, et al.; J. Cell Sci.
116
, 4727 (2003)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-662
Revised 15-Apr-08
Monoclonal Antibody to Progerin (human) (13A4)
