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Items 13 of 13
ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-085
Revised 05-Sep-07
Adenosine-3’,5’-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-cAMPS . Na
cAMPS . Na, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-085-M001
1 mg
120.00 USD
ALX-480-085-M005
5 mg
490.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
73208-40-9
PURITY:
≥99% (low adenosine, cAMP and Sp-cAMPS content)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-012
).
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-012
Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
SYNONYMS
Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-012-M001
1 mg
110.00 USD
ALX-480-012-M005
5 mg
460.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
5
PS . C
6
H
16
N
MW:
345.5 . 101.0
CAS NUMBER:
151837-09-1
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase:
J.D. Rothermel; Biochem. J.
251
, 757 (1988)
Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates:
E. Butt, et al.; FEBS Lett.
263
, 47 (1990)
Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
:
L.Y. Wang, et al.; Science
253
, 1132 (1991)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-086
Revised 30-Aug-06
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-cAMPS . Na
cAMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-086-M001
1 mg
75.00 USD
ALX-480-086-M005
5 mg
300.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
717794-13-5
PURITY:
≥99% (low adenosine, cAMP and Rp-cAMPS content)
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-013
).
Further Categories Containing This Product:
PKA Activators
ALX-480-013
Revised 10-Feb-05
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . triethylammonium salt
SYNONYMS
Sp-cAMPS . TEA
cAMPS . TEA, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-013-M001
1 mg
75.00 USD
ALX-480-013-M005
5 mg
298.00 USD
ALX-480-013-M010
10 mg
580.00 USD
Product Specification
FORMULA:
C
16
H
27
N
6
O
5
PS
MW:
446.5
CAS NUMBER:
93602-66-5
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Considerably higher resistance against cyclic nucleotide-dependent phosphodiesterases as compared to N
6
,O
2'
-dibutyryladenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP) (Prod. No.
ALX-480-045
) or 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) (Prod. No.
ALX-480-007
). No metabolic side effects. Membrane permeable in many biological systems.
Product Specific Literature References
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin- permeabilized parotid acini:
T. Takuma & T. Ichida; J. Biochem.
110
, 292 (1991)
Abstract
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange:
T. Sugimoto, et al.; J. Cell Physiol.
152
, 28 (1992)
Abstract
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone:
H. Kaji, et al.; BBRC
182
, 1356 (1992)
Abstract
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging:
P.J. Sammak, et al.; J. Cell. Biol.
117
, 57 (1992)
Abstract
Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction:
W. Van Der Kloot & D.D. Branisteanu; Pfluegers Arch.
420
, 336 (1992)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-850-013
Revised 24-Feb-05
cAMP EIA Kit
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-013-KI01
1 Kit
412.00 USD
Product Specification
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the measurement of cAMP.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
ELISA & EIA Kits
ALX-480-007
Revised 16-Feb-05
8-Bromoadenosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cAMP, 8-Br-, . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-007-M010
10 mg
42.00 USD
ALX-480-007-M050
50 mg
125.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
P . Na
MW:
407.1 . 23.0
CAS NUMBER:
76939-46-3
PURITY:
≥99% (low in fluorescent and colored impurities)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Has increased metabolic stability and membrane permeability compared with cAMP (Prod. No.
ALX-480-011
).
Further Categories Containing This Product:
PKA Activators
ALX-480-024
Revised 18-Jun-08
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Rp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-024-MC05
0.5 mg
95.00 USD
ALX-480-024-M001
1 mg
175.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
129735-00-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
IDENTITY:
Identity determined by
1
H-NMR, MS and UV.
Product Description
Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No.
ALX-480-012
, and Prod. No.
ALX-480-085
). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No.
ALX-480-007
).
Product Specific Literature References
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase:
A.C. Chao, et al.; EMBO J.
13
, 1065 (1994)
Abstract
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture:
B.T. Gjertsen, et al.; J. Biol. Chem.
270
, 20599 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-025
Revised 26-Jul-06
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-025-M001
1 mg
140.00 USD
ALX-480-025-M005
5 mg
560.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
127634-20-2
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Metabolically resistant activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). No metabolic side effects as observed with dibutyryl-cAMP (N
6
,O
2'
-Dibutyryladenosine 3',5'-cyclic monophosphate, Prod. No.
ALX-480-045
) or 8-Br-cAMP (8-Bromoadenosine-3',5'-cyclic monophosphate, Prod. No.
ALX-480-007
). Significantly more lipophilic and membrane permeant as compared to Sp-cAMPS (Adenosine 3',5'-cyclic monophosphothioate, Sp isomer, Prod. No.
ALX-480-013
).
Product Specific Literature References
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium:
P. Schaap, et al.; J. Biol. Chem.
268
, 6323 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Activators
ALX-480-029
Revised 26-Sep-08
8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
SYNONYMS
8-Cl-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-029-M001
1 mg
27.00 USD
ALX-480-029-M005
5 mg
108.00 USD
Product Specification
FORMULA:
C
10
H
11
ClN
5
O
6
P . Na
MW:
363.7 . 23.0
CAS NUMBER:
41941-56-4
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water and aqueous buffers. May produce hazy solutions.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Specific Literature References
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth:
S. Ally, et al.; PNAS
85
, 6319 (1988)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-480-030
Revised 07-Jun-06
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-pCPT-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-030-M010
10 mg
25.00 USD
ALX-480-030-M025
25 mg
50.00 USD
Product Specification
FORMULA:
