© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
>
NF-kB Pathway
> IkB Kinases [IKKs] / Related Products
ALX-350-246
Revised 07-Oct-08
Butein
SYNONYMS
2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-246-M010
10 mg
190.00 USD
Product Specification
FORMULA:
C
15
H
12
O
5
MW:
272.3
CAS NUMBER:
487-52-5
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (>50mg/ml) or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep cool and dry under inert gas.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Plant polyphenol. Specific tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor and p60
c-
src
. Potent antioxidant and anti-inflammatory agent. Inhibits glutathione reductase and rat liver glutathione S-transferase. Activator of human deacetylase SIRT1. Inhibits aromatase, showing chemopreventive properties. Directly inhibits IKK.
Product Specific Literature References
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects:
E. Aizu, et al.; Carcinogenesis
7
, 1809 (1986)
Abstract
Protective effects of hydroxychalcones on free radical-induced cell damage:
S. Sogawa, et al.; Biol. Pharm. Bull.
17
, 251 (1994)
Abstract
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation:
C.C. Yit & N.P. Das; Cancer Lett.
82
, 65 (1994)
Abstract
Inhibitory effects of plant polyphenols on rat liver glutathione S-transferase:
K. Zhang & N.P. Das; Biochem. Pharmacol.
47
, 2063 (1994)
Abstract
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor:
S.M. Yu, et al.; Eur. J. Pharmacol.
280
, 69 (1995)
Abstract
Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimantal anti-glomerular basement membrane antibody-associated glomerulonephritis (3):
K. Hayashi, et al.; Eur. J. Pharmacol.
316
, 297 (1996)
Abstract
Inhibition of glutathione reductase by plant polyphenols:
K. Zhang, et al.; Biochem. Pharmacol
54
, 1047 (1997)
Abstract
Butein, a specific protein tyrosine kinase inhibitor:
E.-B. Yang, et al.; BBRC
245
, 435 (1998)
Abstract
Antioxidant properties of butein isolated from Dalbergia odorifera:
Z.J. Cheng, et al.; Biochim. Biophys. Acta
1392
, 291 (1998)
Abstract
Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells:
K. Iwashita, et al.; Biosci. Biotechnol. Biochem.
64
, 1813 (2000)
Abstract
Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells:
N.Y. Kim, et al.; Pharmacol. Toxicol.
88
, 261 (2001)
Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
:
K.T. Howitz, et al.; Nature
425
, 191 (2003)
Abstract
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase:
Y. Wang, et al.; Life Sci.
77
, 39 (2005)
Abstract
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue:
M.K. Pandey, et al.; J. Biol. Chem.
282
, 17340 (2007)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
EGFR Kinase Inhibitors
•
Glutathione / Related Products
•
Chalcones
•
Phosphodiesterases / Related Products
•
Natural Products - Chemopreventive Agents
•
Glutathione S-Transferase
•
Sirtuins / Related Products
•
Natural Products - Antioxidants
•
IkB Kinases [IKKs] / Related Products
ALX-804-236
Revised 27-Feb-07
Monoclonal Antibody to IKKα (14A231)
SYNONYMS
anti-Inhibitor of Nuclear Factor κ-B Kinase α MAb (14A231)
anti-IKK1 MAb (14A231)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-236-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Monkey
CLONE:
14A231
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human IKKα (inhibitor of NF-κB kinase α; IKK1).
SPECIFICITY:
Recognizes human, mouse and monkey IKKα. Detects a band of ~85kDa by Western blot.
APPLICATION:
Immunoprecipitation (1-2µg/ml)
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Specific Literature References
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis:
S.K. Manna, et al.; J. Immunol.
165
, 4927 (2000)
Abstract
;
Full Text
KKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
:
Y. Cao, et al.; Cell
107
, 763 (2001)
Abstract
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway
:
D. Koul, et al.; J. Biol. Chem.
276
, 11402 (2001)
Abstract
;
Full Text
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation
:
S. Majumdar & B.B. Aggarwal; J. Immunol.
167
, 2911 (2001)
Abstract
;
Full Text
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation
:
B.S. Miller & E. Zandi; J. Biol. Chem.
276
, 36320 (2001)
Abstract
;
Full Text
NEMO trimerizes through its coiled-coil C-terminal domain
:
F. Agou, et al.; J. Biol. Chem.
277
, 17464 (2002)
Abstract
;
Full Text
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
:
E. Dejardin, et al.; Immunity
17
, 525 (2002)
Abstract
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester:
S. Majumdar, et al.; J. Immunol.
168
, 2644 (2002)
Abstract
;
Full Text
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation
:
C. Makris, et al.; Mol. Cell. Biol.
22
, 6573 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-237
Revised 27-Feb-07
Monoclonal Antibody to IKKβ (human) (10AG2)
SYNONYMS
anti-Inhibitor of Nuclear Factor κ-B Kinase β (human) MAb (10AG2)
anti-IKK2 (human) MAb (10AG2)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-237-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
10AG2
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human IKKβ (inhibitor of NF-κB kinase β; IKK2).
SPECIFICITY:
Recognizes human IKKβ. Detects a band of ~87kDa by Western blot.
APPLICATION:
Western Blot (2-4µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation
:
S. Majumdar & B.B. Aggarwal; J. Immunol.
167
, 2911 (2001)
Abstract
;
Full Text
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester:
S. Majumdar, et al.; J. Immunol.
168
, 2644 (2002)
Abstract
;
Full Text
Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis
:
M. Santos, et al.; J. Biol. Chem.
278
, 14322 (2003)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-424
Revised 22-May-07
Monoclonal Antibody to IKKγ (human) (46B844)
SYNONYMS
anti-Inhibitor of Nuclear Factor κ-B Kinase γ (human) MAb (46B844)
anti-IKK3 (human) MAb (46B844)
anti-NEMO (human) MAb (46B844)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-424-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
46B844
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human IKKγ (inhibitor of NF-κB kinase γ; IKK3; NEMO).
SPECIFICITY:
Recognizes human IKKγ. Detects a band of ~48kDa by Western blot. Does not cross-react with mouse IKKγ.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-321
Revised 22-Nov-07
Monoclonal Antibody to IKKε (72B587)
SYNONYMS
anti-Inhibitor of Nuclear Factor κ-B Kinase ε MAb (72B587)
anti-IKK-i MAb (72B587)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-321-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
72B587
ISOTYPE:
Mouse IgG2aκ
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 175-188 of human IKKε (inhibitor of NF-κB kinase ε
; IKK-i).
SPECIFICITY:
Recognizes human, mouse and rat IKKε. Detects a band of ~80kDa by Western blot.
APPLICATION:
Western Blot (1-3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Specific Literature References
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
:
A. Chariot, et al.; J. Biol. Chem.
277
, 37029 (2002)
Abstract
;
Full Text
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
:
K.A. Fitzgerald, et al.; Nat. Immunol.
4
, 491 (2003)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-372
Revised 22-May-08
Monoclonal Antibody to TANK-binding Kinase 1 (108A429)
SYNONYMS
anti-TBK1 MAb (108A429)
anti-NAK MAb (108A429)
anti-NF-κB-activating Kinase MAb (108A429)
anti-T2K MAb (108A429)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
IkB Kinases [IKKs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-372-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE:
108A429
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 563-577 (YYQFKKDKAERRLAYC) of human TBK1 (TANK-binding kinase 1).
SPECIFICITY:
Recognizes human, mouse, rat, dog and bovine TBK1. Detects a band of ~80kDa by Western blot.
APPLICATION:
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Description
TANK-binding Kinase 1 (TBK1) is a member of the IKK family. TANK (TRAF-associated NF-κB activator) interacts with TBK1 and activates NF-κB in a kinase-dependent manner [1].
Product Specific Literature References
[1]
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase:
J.L. Pomerantz & D. Baltimore; EMBO J.
18
, 6694 (1999)
Abstract
;
Full Text
[2]
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway:
K.A. Fitzgerald, et al.; Nat. Immunol.
4
, 491 (2003)
Abstract
[3]
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I:
R. Sumpter, Jr., et al.; J. Virol.
79
, 2689 (2005)
Abstract
;
Full Text
[4]
Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells:
P. Osterlund, et al.; J. Virol.
79
, 9608 (2005)
Abstract
Further Categories Containing This Product:
Antiviral Signalling / Related Products
•
Monoclonal Antibodies
© 2008 ALEXIS Corporation,
Privacy Policy
,
Disclaimer
,
Feedback
header picture ©
micronaut.ch
, another
CS2
website
